Cancers, Volume 11, Issue 11 (November 2019) – 202 articles
Cover Story (view full-size image): Four mechanistically distinct repair pathways process DNA double-strand breaks induced in the genome by ionizing radiation. They operate on different mechanistic principles and with widely different fidelity, allowing sequence alterations and translocation formation. It remains largely unknown what principles determine their engagement in the processing of a given break, as this is associated with widely different consequences on genome stability. We propose that cells apply logic and explore processing by the pathway with the highest fidelity among those that are available. However, cells also adapt quickly and engage lower-fidelity repair pathways to accommodate necessities generated when the form of chromatin breakage compromises higher-fidelity pathways. In this model, there is no free choice in the selection of a processing pathway. View this paper
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