Special Issue "Pituitary Adenomas: New Insights into Molecular Features, Diagnosis and Therapeutic Targeting"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 30 September 2019

Special Issue Editor

Guest Editor
Prof. Dr. Monica Fedele

CNR—Institute of Experimental Endocrinology and Oncology, 80131 Naples, Italy
Website | E-Mail
Interests: PATZ1; HMGA; chromatin; gene regulation; cancer; biomarkers; animal models; cancer cells; transgenic mice; knockout mice; breast cancer; glioblastoma; thyroid cancer; pituitary adenomas; EMT; cancer stem cells

Special Issue Information

Dear Colleagues,

Recent progress in understanding the molecular features of pituitary adenomas, one of the most frequent intracranial tumors and neuroendocrine neoplasms affecting 1 in 1000 in the general population, allowed us to improve their classification, with an impact on the diagnosis and the prediction of targeted treatments. Pituitary tumorigenesis is driven by diverse mechanisms, including gene amplification, mutation, overexpression, down-regulation and epigenetic silencing, microRNA misexpression, cell cycle dysregulation, endocrine dysfunction, and others.

A deep knowledge of each of these mechanisms, mainly achieved thanks to the use of animal models, is leading to the development of effective therapeutic strategies, even for the most aggressive subtypes, characterized by invasiveness, recurrence, and resistance to conventional treatment.

In this Special Issue, we will publish reviews and original research that provide new insights into signaling pathways and biomarkers driving pituitary tumorigenesis, diagnosis, and therapeutic perspectives. Articles about aggressive pituitary adenomas will be particularly welcomed.

Prof. Dr. Monica Fedele
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Pituitary adenomas
  • Pituitary tumorigenesis
  • Prolactinomas
  • Non-functioning pituitary adenomas
  • Somatotropinomas
  • Adrenocorticotropinomas
  • Mammosomatotroph cell adenomas
  • Thyrotroph cell adenomas
  • Pituitary neuroendocrine tumors
  • Targeted treatment for pituitary adenomas
  • Pituitary adenoma biomarkers

Published Papers

This special issue is now open for submission.
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