Special Issue "Cancer Invasion and Metastasis"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 30 September 2019
The aberrant invasion pathways that are activated in cancer cells underlie the establishment of metastatic programs across numerous malignant disorders. With revolutionary recent breakthroughs in primary cancer management, metastasis continues to present as a major prognostic hurdle. Systemic dissemination represents the final stage of tumor progression, as well as the principal cause of cancer-associated deaths. Over the recent years, scientific advancements continue to shed new light and provide critical insight into the mechanisms associated with metastasis that are needed for designing the next generation of therapeutic modalities. Major innovative insights derived from large-scale sequencing efforts, novel research technologies, various omics-based studies, and integrative analyses of omics data will be fundamental for our understanding of the networks that drive the deregulated invasion and metastatic processes.
In that respect, zooming into the differences of the global cellular landscapes between primary and metastatic tumors are key determinants for the identification of metastasis-driving events. Understanding how various regulatory mechanisms, for example those that involve microRNAs, autophagy, and long non-coding RNAs, are abnormally regulated, and sustaining metastasis will be of utmost importance. The current Special Issue invites contributions that provide novel aspects related to the onset and maintenance of metastasis, with special focus, but not limited to, precision medicine aspects. Particular insights describing the genomics, transcriptomics, proteomics, and posttranslational modifications-related proteomics, metabolomics, and single-cell omics with respect to the biology of metastasis are of great interest. Likewise, research topics focusing on efforts combining novel therapeutic approaches with existing modalities to manage systemic dissemination will also be welcome.
Prof. Dr. Yitzhak Zimmer
PD. Dr. Michaela Medova
Prof. Deborah Stroka
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.