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Toxins, Volume 17, Issue 12

December 2025 - 42 articles

Cover Story: Amanita muscaria (fly agaric) remains an uncommon but clinically significant cause of acute mushroom poisoning, with highly variable toxic effects. This article presents a literature review of this mushroom’s biochemical makeup, toxicodynamics, and clinical manifestations—focusing on the principal toxins ibotenic acid and muscimol—and illustrates these findings through two severe intoxication cases in elderly spouses following home preparation. The cases underscore rapid-onset gastrointestinal symptoms, profound central nervous system depression, and autonomic disturbances, highlighting diagnostic and management challenges. This work emphasizes the need for heightened clinical awareness and improved toxicological preparedness. View this paper
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Articles (42)

  • Review
  • Open Access
387 Views
15 Pages

Fifty Years and Counting: Searching for the “Silver Bullet” or the “Silver Shotgun” to Mitigate Preharvest Aflatoxin Contamination

  • Baozhu Guo,
  • Idrice Carther Kue Foka,
  • Dongliang Wu,
  • Josh P. Clevenger,
  • Rong Di and
  • Jake C. Fountain

15 December 2025

The year 2025 marks two significant milestones for aflatoxin research: 65 years since aflatoxin was first identified in 1960, and 50 years of focused research on preharvest aflatoxin contamination since it was first recognized in 1975. Studies in the...

  • Article
  • Open Access
456 Views
19 Pages

Ultrasound Evaluation of Upper Facial Muscles to Guide Botulinum Toxin Application

  • Dominika Jaguś,
  • Anna Pawłowska and
  • Robert Krzysztof Mlosek

14 December 2025

Background: Botulinum toxin injection is one of the most common esthetic procedures, yet complications may occur due to anatomical variability or suboptimal injection technique. This study aimed to evaluate the upper facial muscles using ultrasound,...

  • Article
  • Open Access
442 Views
15 Pages

11 December 2025

Signs of aging in the upper face arise from multimodal changes in facial anatomy, contributing to concerns such as eyebrow ptosis and forehead lines. While neurotoxin injections are widely used to address these lines, the anatomical variability of th...

  • Article
  • Open Access
372 Views
16 Pages

11 December 2025

Platelet concentrates (PCs) are used to treat patients with platelet deficiencies. PCs are stored at 20–24 °C under agitation for up to 7 days to maintain platelet functionality, but these conditions are amenable for proliferation of contam...

  • Article
  • Open Access
430 Views
14 Pages

Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease

  • Stefania Kapetanaki,
  • Samira Salihovic,
  • Ashok Kumar Kumawat,
  • Ziad A. Massy,
  • Katarina Persson,
  • Peter Barany,
  • Peter Stenvinkel,
  • Marie Evans and
  • Isak Demirel

11 December 2025

Trimethylamine-N-oxide (TMAO), a gut microbiota-derived dietary metabolite, is linked to progression of chronic kidney disease (CKD). Megalin, a renal proximal tubule receptor crucial for albumin reabsorption, also plays a role in CKD. However, the r...

  • Article
  • Open Access
419 Views
15 Pages

Natural Occurrence of Conventional and Emerging Fusarium Mycotoxins in Freshly Harvested Wheat Samples in Xinjiang, China

  • Weihua Zheng,
  • Jinyi Zhang,
  • Yi Shi,
  • Can He,
  • Xiaolong Zhou,
  • Junxi Jiang,
  • Gang Wang,
  • Jingbo Zhang,
  • Jianhong Xu and
  • Jianrong Shi
  • + 2 authors

10 December 2025

Wheat is a major staple crop in Xinjiang, China; however, comprehensive data on Fusarium mycotoxin contamination in wheat from this region remain limited. Despite recent observations of Fusarium head blight (FHB), few studies have characterized the m...

  • Article
  • Open Access
384 Views
19 Pages

Concurrent Quantification of Deoxynivalenol, Its Derivatives, and Nivalenol in Pet Food Using QuEChERS Combined with LC-MS/MS

  • Chae-Eun Yeo,
  • Subin Gwon,
  • Eun Hee Chang,
  • Hyo Young Kim,
  • Sung-Youn Kim,
  • Kangmin Seo,
  • Ji Hye Lee and
  • Hyunjeong Cho

10 December 2025

In the current research, we optimized a simultaneous method for quantifying deoxynivalenol (DON) and its derivative forms, deoxynivalenol-3-glucoside (D3G), 3-acetyl-deoxynivalenol (3-AcDON), 15-acetyl-deoxynivalenol (15-AcDON), and nivalenol (NIV),...

  • Article
  • Open Access
420 Views
22 Pages

9 December 2025

Deoxynivalenol (DON), a mycotoxin produced by Fusarium species, severely contaminates grains and feed, posing a continuous threat to human and livestock health. In this study, the DON-degrading enzyme (DDE) gene from Devosia sp. JA3 was heterologousl...

  • Article
  • Open Access
349 Views
15 Pages

Impact of Regulated and Non-Regulated Food-Associated Mycotoxins on the Viability and Proliferation of Enteric Glial Cells

  • Michał Dąbrowski,
  • Hamza Olleik,
  • Attilio Di Maio,
  • Amine Kadri,
  • Valérie Camps,
  • Josette Perrier,
  • El Hassan Ajandouz,
  • Philippe Pinton,
  • Regiane R. Santos and
  • Isabelle P. Oswald
  • + 2 authors

8 December 2025

(1) Background: Humans and animals are exposed daily to numerous food-associated noxious molecules, including fungal toxins or mycotoxins. Effects of mycotoxins on the intestinal epithelial cells (IECs) are well characterized. However, their impact o...

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Toxins - ISSN 2072-6651