New Insights in Uremic Toxins and Toxin-Related Outcomes in Chronic Kidney Disease
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editors
Interests: uremic toxins; protein-bound uremic toxins; chronic kidney disease; leukocyte/monocyte function; leukocyte–endothelial interaction; inflammation in CKD; dialysis fluid purity/endotoxins; gut–kidney axis
Special Issues, Collections and Topics in MDPI journals
Interests: uraemic toxins; chronic kidney disease; pediatrics; Hemodialysis
Interests: uremia; chronic kidney disease; hemodialysis; adequacy of dialysis; acute kidney injury
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the past decade, insights into uremic toxicity have evolved. The introduction of metabolome analyses has offered a more balanced view on uremic retention by revealing the accumulation of not only toxic but also potentially beneficial retention metabolites. All these metabolites, which are secreted by organs or absorbed via the intestine into the circulation, can, together with signaling molecules, receptors, transporter proteins and enzymes, remotely affect multiple organs and lead to disordered communication. Knowledge about the origin (diet, gut microbiota and host metabolism) and biological impact (increased inflammation and sex-related aspects) of uremic toxins has grown. A lot can also be learned from veterinary studies on uremic toxins in kidney disease. While promising innovations for the treatment of advanced kidney failure, such as portable dialysis and bio-artificial kidneys, are under development, increased attention is now also paid to preventive and life-style measures to limit the accumulation of uremic toxins, their toxicity, and their effect on outcomes in CKD. This Special Issue, titled “New Insights in Uremic Toxins and Toxin-Related Outcomes in Chronic Kidney Disease”, welcomes submissions related to the topics described above.
Prof. Dr. Griet Glorieux
Prof. Dr. Evelien Snauwaert
Prof. Dr. Raymond Vanholder
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- uremic toxins
- metabolome
- nutrition
- diet
- dialysis
- sex-related
- inflammation
- aryl hydrocarbon receptor
- post-translational modifications
- human
- veterinary
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