Table of Contents
Pharmaceutics, Volume 12, Issue 4 (April 2020) – 97 articles
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Cover Story (view full-size image) Nanoparticles and their cargo are taken up by the cells through different pathways, including [...] Read more. Nanoparticles and their cargo are taken up by the cells through different pathways, including simple diffusion, phagocytosis, and pinocytosis, the latter including macropinocytosis and receptor-mediated endocytosis (both clathrin- and caveolin-mediated). The different routes used by nanoparticles to enter the cells are relevant because they decide the total amount transported to the cell interior and the final location of both nanoparticles and its cargo inside the cell. Knowing the key factors involved in directing nanoparticles toward different cellular uptake routes will markedly improve nanoparticle design and effectiveness as delivery tools for therapeutic agents. View this paper.