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Review

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

1
Unidad Asociada Neurodeath, Universidad de Castilla-La Mancha, 02006 Albacete, Spain
2
CIBERNED, Instituto de Salud Carlos III, 28031 Madrid, Spain
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(4), 371; https://doi.org/10.3390/pharmaceutics12040371
Received: 23 March 2020 / Revised: 10 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Cancer Nanomedicine—From the Bench to the Bedside)
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering therapeutic compounds to cells. Their entry into the cell represents the initial step in this delivery process, being most of the nanoparticles taken up by endocytosis, although other mechanisms can contribute to the uptake. To increase the delivery efficiency of therapeutic compounds by NPs and submicron particles is very relevant to understand the mechanisms involved in the uptake process. This review covers the proposed pathways involved in the cellular uptake of different NPs and submicron particles types as well as the role that some of the physicochemical nanoparticle characteristics play in the uptake pathway preferentially used by the nanoparticles to gain access and deliver their cargo inside the cell. View Full-Text
Keywords: nanoparticles; endocytosis; clathrin; caveolin; macropinocytosis nanoparticles; endocytosis; clathrin; caveolin; macropinocytosis
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MDPI and ACS Style

Manzanares, D.; Ceña, V. Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell. Pharmaceutics 2020, 12, 371. https://doi.org/10.3390/pharmaceutics12040371

AMA Style

Manzanares D, Ceña V. Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell. Pharmaceutics. 2020; 12(4):371. https://doi.org/10.3390/pharmaceutics12040371

Chicago/Turabian Style

Manzanares, Darío, and Valentín Ceña. 2020. "Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell" Pharmaceutics 12, no. 4: 371. https://doi.org/10.3390/pharmaceutics12040371

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