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Viruses, Volume 17, Issue 7

July 2025 - 153 articles

Cover Story: Mother-to-child transmission of HIV-1 and pediatric ART may influence virologic and immune features, resulting in differences in the infected cell populations that persist compared to adults who acquire HIV-1. Using long-amplicon proviral sequencing, we investigated the characteristics of proviruses that persisted in five children for 7–9 years on ART. We found fewer intact proviruses, fewer mutations in the major splice donor (MSD) site, and a higher proportion of proviruses with defective tat compared to adults on long-term ART. Our results suggest that immune and ART pressures may shape a qualitatively different HIV proviral landscape in children that may influence targets for measuring and eliminating the HIV reservoir and achieving remission without ART. View this paper
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Articles (153)

  • Article
  • Open Access
877 Views
14 Pages

Investigation of the Mouse Infection Model for Echovirus 18

  • Lei Xiang,
  • Linlin Zhai,
  • Guanyong Ou,
  • Wei Zhao,
  • Yang Yang and
  • Chenguang Shen

18 July 2025

Echovirus 18, a member of the B group of enteroviruses, is a significant etiological agent of aseptic meningitis and viral encephalitis in children. In this study, we investigated the pathogenicity of E18 by establishing a mouse infection model after...

  • Article
  • Open Access
1 Citations
1,281 Views
16 Pages

18 July 2025

The wheat curl mite (WCM, Aceria tosichella Keifer), a complex of eriophyid mite species, transmits wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV), which in single or mixed infections cause wheat streak mosaic (WSM) disease—...

  • Article
  • Open Access
817 Views
15 Pages

Overexpression of Interleukin-17 Modulates Responses to Marek’s Disease Virus Infection and Tumor Formation in Chickens

  • Nitish Boodhoo,
  • Katherine Blake,
  • Fatemeh Fazel,
  • Janan Shoja Doost and
  • Shayan Sharif

18 July 2025

Marek’s Disease Virus (MDV) is a highly contagious pathogen in chickens, resulting in immunosuppression and T-cell lymphomas. Understanding the role of host cytokines in MDV pathogenesis is crucial for developing effective interventions. This s...

  • Article
  • Open Access
1,675 Views
22 Pages

Spatiotemporal Dynamics of Emerging Foot-and-Mouth Disease, Bluetongue, and Peste Des Petits Ruminants in Algeria

  • Ilhem Zouyed,
  • Sabrina Boussena,
  • Nacira Ramdani,
  • Houssem Eddine Damerdji,
  • Julio A. Benavides and
  • Hacène Medkour

17 July 2025

Foot-and-mouth disease (FMD), bluetongue (BT), and Peste des Petits Ruminants (PPR) are major emerging and re-emerging viral infections affecting ruminants. These diseases can threaten livestock health, food security, and economic stability in low- a...

  • Communication
  • Open Access
1,117 Views
8 Pages

A Strand-Specific Quantitative RT-PCR Method for Detecting vRNA, cRNA, and mRNA of H7N9 Avian Influenza Virus in a Mouse Model

  • Bo Wang,
  • Guangwen Wang,
  • Yi-han Wang,
  • Xuwei Liu,
  • Manman Li,
  • Huihui Kong,
  • Hualan Chen,
  • Li Jiang and
  • Chengjun Li

17 July 2025

Avian influenza virus (AIV) remains a persistent threat to both the poultry industry and human health. Among the AIV subtypes posing public health threats, H7N9 AIV is responsible for five epidemic waves of human infection in China. Here, a detection...

  • Review
  • Open Access
1 Citations
1,132 Views
34 Pages

Non-Coding RNAs and Immune Evasion in Human Gamma-Herpesviruses

  • Tablow S. Media,
  • Laura Cano-Aroca and
  • Takanobu Tagawa

17 July 2025

Herpesviruses are DNA viruses that evade the immune response and persist as lifelong infections. Human gamma-herpesviruses Epstein–Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) are oncogenic; they can lead to cancer. Oncogenic...

  • Article
  • Open Access
776 Views
14 Pages

Serum sICAM-1 and Galectin-3 Levels in Diabetic Patients with COVID-19

  • Busra Karahan,
  • Dogan Nasir Binici,
  • Omer Karasahin,
  • Sibel İba Yilmaz,
  • Ahmet Kiziltunc and
  • Filiz Mercantepe

17 July 2025

Introduction: This study aimed to evaluate the diagnostic and prognostic value of soluble intercellular adhesion molecule-1 (sICAM-1) and galectin-3 in patients with type 2 diabetes mellitus (T2D) diagnosed with coronavirus disease 2019 (COVID-19). P...

  • Article
  • Open Access
1,180 Views
9 Pages

Innovating Quality Control and External Quality Assurance for HIV-1 Recent Infection Testing: Empowering HIV Surveillance in Lao PDR

  • Supaporn Suparak,
  • Kanokwan Ngueanchanthong,
  • Petai Unpol,
  • Siriphailin Jomjunyoung,
  • Wipawee Thanyacharern,
  • Sirilada Pimpa Chisholm,
  • Nitis Smanthong,
  • Pojaporn Pinrod,
  • Thitipong Yingyong and
  • Phonepadith Xangsayarath
  • + 6 authors

17 July 2025

Quality assurance programs are critical to ensuring the consistency and reliability of point-of-care surveillance test results. In 2022, we launched Laos’ inaugural quality control (QC) and external quality assessment (EQA) program for national...

  • Review
  • Open Access
1 Citations
1,593 Views
22 Pages

17 July 2025

Hendra virus (HeV) and Nipah virus (NiV) are two highly pathogenic RNA viruses with zoonotic potential, which can cause severe diseases with high mortality rates (50–100%) in humans and animals. Given this context, these viruses are classified...

  • Review
  • Open Access
1 Citations
1,421 Views
18 Pages

17 July 2025

Respiratory viral infections are a leading cause of early childhood hospitalizations in the United States. Neonatal immune responses are reliant on innate mechanisms during the first few months of life. Interferons (IFNs) are a key component of this...

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Viruses - ISSN 1999-4915