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Current Oncology, Volume 29, Issue 5

May 2022 - 69 articles

Cover Story: Urothelial carcinoma is a complex cancer with genomic immunomic drivers that have prognostic and predictive treatment implications. Identifying potential targetable alterations via next-generation sequencing and RNA sequencing may allow for elucidation of such targets and exploitation with targeted therapeutics. The role of immunotherapy in treating urothelial carcinoma has shown benefit, but it is unclear in which patients immunotherapeutics have the highest yield. Continuing efforts into better identifying which patients may benefit most from targeted therapies, immunotherapies, and combination therapies may ultimately lead to improved outcomes for patients with this disease. View this paper
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Articles (69)

  • Review
  • Open Access
84 Citations
15,799 Views
13 Pages

23 May 2022

Human papillomavirus (HPV) vaccination prevents cervical, head and neck, and anogenital cancers. However, global HPV vaccine coverage falls short of global targets and has seen unexpected and dramatic declines in some countries. This paper synthesize...

  • Article
  • Open Access
3,106 Views
10 Pages

The Effect of Surgeon Volume on the Outcome of Laser Vaporization: A Single-Center Retrospective Study

  • Michihide Maeda,
  • Tsuyoshi Hisa,
  • Shinya Matsuzaki,
  • Misooja Lee,
  • Seiji Mabuchi and
  • Shoji Kamiura

23 May 2022

Although laser vaporization is a popular minimally invasive treatment for cervical intraepithelial neoplasia (CIN), factors influencing CIN recurrence are understudied. Moreover, the effect of surgeon volume on patients’ prognosis after laser v...

  • Review
  • Open Access
1 Citations
4,629 Views
11 Pages

The Evolution of Our Understanding of Immunoproliferative Small Intestinal Disease (IPSID) over Time

  • Ruah AlYamany,
  • Mohamed A. Kharfan-Dabaja,
  • Mehdi Hamadani,
  • Alfadel Alshaibani and
  • Mahmoud Aljurf

23 May 2022

Immunoproliferative small intestinal disease (IPSID) is an uncommon disease with a higher prevalence in the developing world. IPSID diagnosis relies mainly on a tissue biopsy and a high index of suspicion. Treatment options are variable; however, the...

  • Case Report
  • Open Access
9 Citations
5,368 Views
11 Pages

HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature

  • Laurent Mathiot,
  • Guillaume Herbreteau,
  • Siméon Robin,
  • Charlotte Fenat,
  • Jaafar Bennouna,
  • Christophe Blanquart,
  • Marc Denis and
  • Elvire Pons-Tostivint

20 May 2022

Introduction: Assessment of actionable gene mutations and oncogene fusions have made a paradigm shift in treatment strategies of non-small cell lung cancer (NSCLC). HRAS mutations involved around 0.2–0.8% of NSCLC patients, mostly on codon 61....

  • Communication
  • Open Access
8 Citations
4,182 Views
10 Pages

Successes and Challenges of Implementing Tobacco Dependency Treatment in Health Care Institutions in England

  • Sanjay Agrawal,
  • Zaheer Mangera,
  • Rachael L. Murray,
  • Freya Howle and
  • Matthew Evison

20 May 2022

There is a significant body of evidence that delivering tobacco dependency treatment within acute care hospitals can deliver high rates of tobacco abstinence and substantial benefits for both patients and the healthcare system. This evidence has driv...

  • Article
  • Open Access
6 Citations
2,982 Views
10 Pages

19 May 2022

Minimally invasive surgery may not be an appropriate surgical approach in intermediate- and high-risk endometrial carcinoma, even though adjuvant therapy is given. The objective of this study was to evaluate the results of open surgery including lymp...

  • Systematic Review
  • Open Access
17 Citations
5,315 Views
20 Pages

Neoadjuvant Short-Course Radiotherapy Followed by Consolidation Chemotherapy before Surgery for Treating Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis

  • Chun-Kai Liao,
  • Ya-Ting Kuo,
  • Yueh-Chen Lin,
  • Yih-Jong Chern,
  • Yu-Jen Hsu,
  • Yen-Lin Yu,
  • Jy-Ming Chiang,
  • Pao-Shiu Hsieh,
  • Chien-Yuh Yeh and
  • Jeng-Fu You

19 May 2022

Neoadjuvant short course radiotherapy (SCRT) followed by consolidation chemotherapy (CCT) is an alternative treatment for locally advanced rectal cancer (LARC). We performed this systematic review and meta-analysis to explore the tumor response and o...

  • Review
  • Open Access
8 Citations
3,603 Views
10 Pages

Striving to Fill in Gaps between Clinical Practice and Standards: The Evolution of a Pan-Canadian Approach to Patient-Reported Outcomes Use

  • Amanda Caissie,
  • Robert Olson,
  • Lisa Barbera,
  • Jennifer O’Donnell,
  • Carol-Anne Davis,
  • Jennifer Croke,
  • Louise Bird,
  • John Kildea,
  • Erika Brown and
  • Michael Brundage
  • + 1 author

19 May 2022

Despite the known importance and necessity of the standardized collection and use of patient-reported outcomes (PROs), there remain challenges to successful clinical implementation. Facilitated through a quality improvement initiative spearheaded by...

  • Review
  • Open Access
20 Citations
5,408 Views
30 Pages

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma—Where Are We Now?

  • Jennifer A. Silver,
  • Sena Turkdogan,
  • Catherine F. Roy,
  • Thavakumar Subramaniam,
  • Melissa Henry and
  • Nader Sadeghi

18 May 2022

The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high...

  • Article
  • Open Access
4 Citations
3,171 Views
10 Pages

Mutation Profiles of Ovarian Seromucinous Borderline Tumors in Japanese Patients

  • Hiroki Sasamori,
  • Kentaro Nakayama,
  • Sultana Razia,
  • Hitomi Yamashita,
  • Tomoka Ishibashi,
  • Masako Ishikawa,
  • Seiya Sato,
  • Satoru Nakayama,
  • Yoshiro Otsuki and
  • Ritsuto Fujiwaki
  • + 2 authors

18 May 2022

Ovarian seromucinous tumors (SMBTs) are relatively rare, and their carcinogenesis is largely unknown. In this study, the molecular features of SMBTs in Japan are assessed. DNA was extracted from microdissected paraffin-embedded sections from 23 SMBT...

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Curr. Oncol. - ISSN 1718-7729