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Marine Drugs, Volume 21, Issue 7

July 2023 - 52 articles

Cover Story: In this review, we provide comprehensive information about how flow chemistry has contributed to the development of marine drugs in recent decades. This novel synthetic technology has facilitated difficult synthetic pathways in a more efficient and safer manner, increasing the benefits of using this technique over the batch mode. Thus, a plethora of organic reactions with promising biological activities have been achieved in a wide range of marine drug-like molecules. View this paper
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Articles (52)

  • Review
  • Open Access
16 Citations
4,682 Views
20 Pages

Marine Microbial Polysaccharides: An Untapped Resource for Biotechnological Applications

  • Rajesh Jeewon,
  • Aadil Ahmad Aullybux,
  • Daneshwar Puchooa,
  • Nadeem Nazurally,
  • Abdulwahed Fahad Alrefaei and
  • Ying Zhang

24 July 2023

As the largest habitat on Earth, the marine environment harbors various microorganisms of biotechnological potential. Indeed, microbial compounds, especially polysaccharides from marine species, have been attracting much attention for their applicati...

  • Article
  • Open Access
4 Citations
3,463 Views
16 Pages

Exopolysaccharide Production from Marine-Derived Brevundimonas huaxiensis Obtained from Estremadura Spur Pockmarks Sediments Revealing Potential for Circular Economy

  • Marta Catalão,
  • Mafalda Fernandes,
  • Lorena Galdon,
  • Clara F. Rodrigues,
  • Rita G. Sobral,
  • Susana P. Gaudêncio and
  • Cristiana A. V. Torres

23 July 2023

Marine environments represent an enormous biodiversity reservoir due to their numerous different habitats, being abundant in microorganisms capable of producing biomolecules, namely exopolysaccharides (EPS), with unique physical characteristics and a...

  • Article
  • Open Access
9 Citations
3,865 Views
13 Pages

Functional Characterization of Lycopene β- and ε-Cyclases from a Lutein-Enriched Green Microalga Chlorella sorokiniana FZU60

  • Hong Fang,
  • Junjie Liu,
  • Ruijuan Ma,
  • Yiping Zou,
  • Shih-Hsin Ho,
  • Jianfeng Chen and
  • Youping Xie

23 July 2023

Lutein is a high-value carotenoid with many human health benefits. Lycopene β- and ε-cyclases (LCYB and LCYE, respectively) catalyze the cyclization of lycopene into distinct downstream branches, one of which is the lutein biosynthesis p...

  • Review
  • Open Access
12 Citations
4,071 Views
37 Pages

Extracellular Matrix of Echinoderms

  • Igor Yu. Dolmatov and
  • Vladimir A. Nizhnichenko

22 July 2023

This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization. It includes a wide range of structural ECM proteins, as well as variou...

  • Feature Paper
  • Article
  • Open Access
8 Citations
5,331 Views
26 Pages

Identification of Marine Biotechnology Value Chains with High Potential in the Northern Mediterranean Region

  • Ana Rotter,
  • Antonia Giannakourou,
  • Jesús E. Argente García,
  • Grazia Marina Quero,
  • Charlène Auregan,
  • George Triantaphyllidis,
  • Amalia Venetsanopoulou,
  • Roberta De Carolis,
  • Chrysa Efstratiou and
  • Marina Aboal
  • + 22 authors

22 July 2023

Marine (blue) biotechnology is an emerging field enabling the valorization of new products and processes with massive potential for innovation and economic growth. In the Mediterranean region, this innovation potential is not exploited as well as in...

  • Article
  • Open Access
12 Citations
6,458 Views
29 Pages

21 July 2023

Cladostephus spongiosus was harvested once a month during its growing season (from May to August) from the Adriatic Sea. Algal volatile organic compounds (VOCs) were obtained by headspace solid-phase microextraction (HS-SPME) and hydrodistillation (H...

  • Article
  • Open Access
10 Citations
3,255 Views
21 Pages

Kinetic Extraction of Fucoxanthin from Undaria pinnatifida Using Ethanol as a Solvent

  • Catarina Lourenço-Lopes,
  • Aurora Silva,
  • Paula Garcia-Oliveira,
  • Anton Soria-Lopez,
  • Javier Echave,
  • Clara Grosso,
  • Lucia Cassani,
  • Maria Fatima Barroso,
  • Jesus Simal-Gandara and
  • Maria Fraga-Corral
  • + 1 author

21 July 2023

Fucoxanthin (Fx) has been proven to exert numerous biological properties, which makes it an interesting molecule with diverse industrial applications. In this study, the kinetic behavior of Fx was studied to optimize three variables: time (t—3...

  • Perspective
  • Open Access
7 Citations
3,330 Views
25 Pages

Case Studies in Molecular Network-Guided Marine Biodiscovery

  • Shamsunnahar Khushi,
  • Angela A. Salim and
  • Robert J. Capon

20 July 2023

In reviewing a selection of recent case studies from our laboratory, we revealed some lessons learned and benefits accrued from the application of mass spectrometry (MS/MS) molecular networking in the field of marine sponge natural products. Molecula...

  • Article
  • Open Access
39 Citations
3,235 Views
20 Pages

1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1

  • Daniela Carbone,
  • Camilla Pecoraro,
  • Giovanna Panzeca,
  • Geng Xu,
  • Margot S. F. Roeten,
  • Stella Cascioferro,
  • Elisa Giovannetti,
  • Patrizia Diana and
  • Barbara Parrino

19 July 2023

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety, was efficiently synthesized. The antiproliferative activity of all synthesized derivatives w...

  • Article
  • Open Access
8 Citations
4,644 Views
15 Pages

Scenedesmus rubescens Heterotrophic Production Strategies for Added Value Biomass

  • Gonçalo Espírito Santo,
  • Ana Barros,
  • Margarida Costa,
  • Hugo Pereira,
  • Mafalda Trovão,
  • Helena Cardoso,
  • Bernardo Carvalho,
  • Maria Soares,
  • Nádia Correia and
  • Joana T. Silva
  • + 2 authors

19 July 2023

Microalgae attract interest worldwide due to their potential for several applications. Scenedesmus is one of the first in vitro cultured algae due to their rapid growth and handling easiness. Within this genus, cells exhibit a highly resistant wall a...

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Mar. Drugs - ISSN 1660-3397