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Current Issues in Molecular Biology, Volume 46, Issue 2

February 2024 - 45 articles

Cover Story: Diabetes is caused by abnormal glucose metabolism, and muscle, the largest tissue in the human body, is largely involved. Therefore, therapeutic approaches targeting abnormalities in muscle glucose metabolism are effective. In the present study, we focused on urolithin A (UroA), a major intestinal metabolite of ellagic acid and ellagitannins, which are polyphenols found in fruits such as strawberries, and investigated its potential antidiabetic effects using cultured myotubes and a mouse model of type 2 diabetes. Results suggested that UroA promotes glucose uptake by inducing the translocation of glucose transporter 4 to the plasma membrane via activation of both PI3K/Akt and AMPK pathways in muscle. Based on these results, UroA is expected to be a biofactor with antidiabetic effects. View this paper
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Articles (45)

  • Article
  • Open Access
1 Citations
1,876 Views
15 Pages

Molecular Characterization and Phylogenetic Analysis of Centipedegrass [Eremochloa ophiuroides (Munro) Hack.] Based on the Complete Chloroplast Genome Sequence

  • Haoran Wang,
  • Yuan Zhang,
  • Ling Zhang,
  • Jingjing Wang,
  • Hailin Guo,
  • Junqin Zong,
  • Jingbo Chen,
  • Dandan Li,
  • Ling Li and
  • Jianxiu Liu
  • + 1 author

19 February 2024

Centipedegrass (Eremochloa ophiuroides) is an important warm-season grass plant used as a turfgrass as well as pasture grass in tropical and subtropical regions, with wide application in land surface greening and soil conservation in South China and...

  • Article
  • Open Access
4 Citations
4,674 Views
14 Pages

Anticancer Effect by Combined Treatment of Artemisia annua L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells

  • Eun Joo Jung,
  • Hye Jung Kim,
  • Sung Chul Shin,
  • Gon Sup Kim,
  • Jin-Myung Jung,
  • Soon Chan Hong,
  • Ky Hyun Chung,
  • Choong Won Kim and
  • Won Sup Lee

19 February 2024

Docetaxel (DTX), a semi-synthetic analogue of paclitaxel (taxol), is known to exert potent anticancer activity in various cancer cells by suppressing normal microtubule dynamics. In this study, we examined how the anticancer effect of DTX is regulate...

  • Article
  • Open Access
6 Citations
2,025 Views
14 Pages

MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2

  • Roberta Lattanzi,
  • Ida Casella,
  • Maria Rosaria Fullone,
  • Daniela Maftei,
  • Martina Vincenzi and
  • Rossella Miele

17 February 2024

Melanocortin receptor accessory protein 2 (MRAP2) is a membrane protein that binds multiple G protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, including prokineticin receptors. These GPCRs are expressed both centrally...

  • Article
  • Open Access
4 Citations
2,056 Views
14 Pages

Plastoquinone-Derivative SkQ1 Improved the Biliary Intraepithelial Neoplasia during Liver Fluke Infection

  • Oxana Zaparina,
  • Anna Kovner,
  • Viktoria Petrova,
  • Nataliya Kolosova,
  • Viatcheslav Mordvinov and
  • Maria Pakharukova

17 February 2024

Carcinogenic food-borne liver fluke infections are a serious epidemiological threat worldwide. The major complications of Opisthorchis felineus infection are chronic inflammation and biliary intraepithelial neoplasia. Although evidence has accumulate...

  • Article
  • Open Access
11 Citations
2,939 Views
14 Pages

The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury

  • Dilek Aygün Keşim,
  • Fırat Aşır,
  • Hayat Ayaz and
  • Tuğcan Korak

16 February 2024

This study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape softw...

  • Article
  • Open Access
5 Citations
4,187 Views
12 Pages

Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts

  • Savni Sawant,
  • Oladele A. Oluwayiose,
  • Karolina Nowak,
  • DruAnne L. Maxwell,
  • Emily Houle,
  • Amanda L. Paskavitz,
  • Hachem Saddiki,
  • Ricardo P. Bertolla and
  • J. Richard Pilsner

16 February 2024

The well-documented relationship between chronological age and the sperm methylome has allowed for the construction of epigenetic clocks that estimate the biological age of sperm based on DNA methylation, which we previously termed sperm epigenetic a...

  • Communication
  • Open Access
3 Citations
2,120 Views
11 Pages

The Role of Rv1476 in Regulating Stress Response and Intracellular Survival of Mycobacterium tuberculosis

  • Aikebaier Reheman,
  • Yifan Wang,
  • Huaiyuan Cai,
  • Pingyang Wei,
  • Gang Cao and
  • Xi Chen

16 February 2024

The virulence of Mycobacterium tuberculosis (M. tuberculosis) is related to many factors, including intracellular survival, cell wall permeability, and cell envelope proteins. However, the biological function of the M. tuberculosis membrane protein R...

  • Article
  • Open Access
7 Citations
3,740 Views
26 Pages

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study

  • Laurent Peno-Mazzarino,
  • Nikita Radionov,
  • Marián Merino,
  • Sonia González,
  • José L. Mullor,
  • Jonathan Jones and
  • Nuria Caturla

15 February 2024

Air pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation....

  • Article
  • Open Access
8 Citations
2,487 Views
14 Pages

Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis

  • Li-Jane Shih,
  • Po-Chi Hsu,
  • Chih-Pin Chuu,
  • Hao-Ai Shui,
  • Chien-Chih Yeh,
  • Yueh-Chung Chen and
  • Yung-Hsi Kao

14 February 2024

Carcinogens, such as arecoline, play a crucial role in cancer progression and continuous gene mutations by generating reactive oxygen species (ROS). Antioxidants can reduce ROS levels and potentially prevent cancer progression but may paradoxically e...

  • Communication
  • Open Access
10 Citations
3,048 Views
13 Pages

Variability in Leaf Color Induced by Chlorophyll Deficiency: Transcriptional Changes in Bamboo Leaves

  • Peng-Kai Zhu,
  • Mei-Yin Zeng,
  • Yu-Han Lin,
  • Yu Tang,
  • Tian-You He,
  • Yu-Shan Zheng and
  • Ling-Yan Chen

14 February 2024

The diversity of leaf characteristics, particularly leaf color, underscores a pivotal area of inquiry within plant science. The synthesis and functionality of chlorophyll, crucial for photosynthesis, largely dictate leaf coloration, with varying conc...

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Curr. Issues Mol. Biol. - ISSN 1467-3045