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Pharmaceuticals, Volume 15, Issue 6

June 2022 - 121 articles

Cover Story: Many metered-dose inhaler (MDI) users with respiratory diseases cannot comply well with instructions and inhale differently during MDI actuation. A computational model was developed to investigate the pulmonary drug delivery from a ProAir MDI under varying inhalation depths. Experimental measurements were implemented as initial/boundary conditions for the spray aerosols from the actuator orifice. Remarkable differences were predicted in airflow dynamics and dosimetry in the MDI mouthpiece and oral cavity. Model cross-validation with existing experiments indicated a high dosimetry sensitivity to the initial spray properties (size and velocity) and transient inhalation rate. The results highlight the importance of personalized inhalation therapy to match patients’ breathing patterns for optimal delivery efficiencies. View this paper
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Articles (121)

  • Review
  • Open Access
33 Citations
6,079 Views
11 Pages

Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT)...

  • Article
  • Open Access
11 Citations
3,952 Views
24 Pages

Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria

  • Giannamaria Annunziato,
  • Costanza Spadini,
  • Marialaura Marchetti,
  • Nina Franko,
  • Marialaura Pavone,
  • Mattia Iannarelli,
  • Agostino Bruno,
  • Marco Pieroni,
  • Stefano Bettati and
  • Clotilde Silvia Cabassi
  • + 2 authors

Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence of antibacterial resistance. Herein, we report that O-acetylserine sulfhydrylase (OASS) in...

  • Brief Report
  • Open Access
4 Citations
3,636 Views
11 Pages

Cardio- and Neurotoxicity of Selected Anti-COVID-19 Drugs

  • Martin W. Nicholson,
  • Ching-Ying Huang,
  • Jyun-Yuan Wang,
  • Chien-Yu Ting,
  • Yu-Che Cheng,
  • Darien Z. H. Chan,
  • Yi-Chan Lee,
  • Ching-Chuan Hsu,
  • Yu-Hung Hsu and
  • Cindy M. C. Chang
  • + 9 authors

Since December 2019, the novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected ~435 million people and caused ~6 million related deaths as of March 2022. To combat COVID-19, th...

  • Systematic Review
  • Open Access
12 Citations
9,161 Views
38 Pages

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

  • Sze Yuen Lew,
  • Michael Weng Lok Phang,
  • Pit Shan Chong,
  • Jaydeep Roy,
  • Chi Him Poon,
  • Wing Shan Yu,
  • Lee Wei Lim and
  • Kah Hui Wong

Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of rare neurodegenerative inherited disorders. The resulting motor incoordination and progressive functional disabilities lead to reduced lifespan. There is currently no cure fo...

  • Article
  • Open Access
8 Citations
3,488 Views
12 Pages

Background: The present work represents a feasibility study for the realization of an analytical method finalized to the detection of expired antibiotic tablets. The work focuses on a specific antibiotic drug and represents the preliminary study upst...

  • Review
  • Open Access
41 Citations
13,134 Views
20 Pages

Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise. Consequently, there is an increasing...

  • Article
  • Open Access
17 Citations
3,774 Views
15 Pages

Multi-Dose Intravenous Administration of Neutral and Cationic Liposomes in Mice: An Extensive Toxicity Study

  • Stéphanie Andrade,
  • Joana A. Loureiro,
  • Santiago Ramirez,
  • Celso S. G. Catumbela,
  • Claudio Soto,
  • Rodrigo Morales and
  • Maria Carmo Pereira

Liposomes are widely used as delivery systems for therapeutic purposes. However, the toxicity associated with the multi-dose administration of these nanoparticles is not fully elucidated. Here, we evaluated the toxicity of the prolonged administratio...

  • Article
  • Open Access
21 Citations
3,726 Views
19 Pages

Development of a Citric-Acid-Modified Cellulose Adsorbent Derived from Moringa peregrina Leaf for Adsorptive Removal of Citalopram HBr in Aqueous Solutions

  • Syed Najmul Hejaz Azmi,
  • Wafa Mustafa Al Lawati,
  • Umaima Hamed Abdullah Al Hoqani,
  • Ekhlas Al Aufi,
  • Khalsa Al Hatmi,
  • Jumana Salim Al Zadjali,
  • Nafisur Rahman,
  • Mohd Nasir,
  • Habibur Rahman and
  • Shah A. Khan

A citric-acid-modified Moringa peregrina leaf substrate was prepared and studied as an effective adsorbent for the adsorptive removal of citalopram HBr (CTM). FTIR spectra were utilized to characterize the prepared solid. The effects of experimental...

  • Article
  • Open Access
4 Citations
3,599 Views
19 Pages

Use of an Electronic Medication Management Support System in Patients with Polypharmacy in General Practice: A Quantitative Process Evaluation of the AdAM Trial

  • Robin Brünn,
  • Dorothea Lemke,
  • Jale Basten,
  • Petra Kellermann-Mühlhoff,
  • Juliane Köberlein-Neu,
  • Christiane Muth,
  • Marjan van den Akker and
  • on behalf of the AdAM Study Group

Polypharmacy is associated with a risk of negative health outcomes. Potentially inappropriate medications, interactions resulting from contradicting medical guidelines, and inappropriate monitoring, all increase the risk. This process evaluation (PE)...

  • Article
  • Open Access
15 Citations
4,105 Views
20 Pages

Ginsenoside Rh3 Inhibits Lung Cancer Metastasis by Targeting Extracellular Signal-Regulated Kinase: A Network Pharmacology Study

  • Xiaodan Xue,
  • Yannan Liu,
  • Linlin Qu,
  • Cuiying Fan,
  • Xiaoxuan Ma,
  • Pingkai Ouyang and
  • Daidi Fan

Lung cancer has a high mortality rate and is very common. One of the main reasons for the poor prognosis of patients with lung cancer is the high incidence of metastasis. Ginsenoside Rh3, a rare ginsenoside extracted from Panax notoginseng, exhibits...

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Pharmaceuticals - ISSN 1424-8247