Metal-Based Agents in Drug Discovery
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 21457
Special Issue Editor
Interests: medicinal chemistry; biologically active metal complexes; ligand–biomolecule interactions; molecular probes and sensors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the plethora of available therapeutics with various properties, we continue to struggle with many diseases, adverse drug reactions, and drug resistance. Therefore, new molecules that can be used as medical therapeutics are, and will always be, highly demanded. This irrefutably implies a necessity for constant studies on the chemotherapy and therapeutic agents, not only from the medical perspective but also as a challenge for the fundamental sciences.
The discovery and subsequent widespread use of cisplatin has placed transition metal coordination chemistry at the frontline in the fight against cancer. This has led, among others, to the exploration and synthesis of different drugs that are based on other metal ions, which can be very interesting from a medicinal point of view because inorganic and coordination chemistry offers additional opportunities for the design of therapeutic agents otherwise unavailable to organic chemistry. The wide range of coordination numbers and geometries, different available redox states and various thermodynamic and kinetic properties as well as the intrinsic properties of metal ions may result in a variety of interactions not possible for organic compounds.
Indeed, transition metal complexes can show antitumor, antibacterial, antifungal, antiviral, and anti-inflammatory activities, which result in their being promising and suitable candidates as drugs. Additionally, it is known that any structural modifications of chemotherapeutic agents or their interactions with metal ions, including ions that are present in the organism, can significantly affect their pharmacological effectiveness. The binding of metal ions to the available electron donor groups of applied drugs can affect both their activity, digestibility, and degree of toxicity.
In this Special Issue “Metal-Based Agents in Drug Discovery”, we wish to focus on not only the design, synthesis, and application of metal coordination compounds as therapeutic agents but also on the interactions of metal ions with drugs or cellular targets. Research articles, comprehensive reviews, and short communications are welcome. Our aim is to collect and present the most recent insights and results involving multidisciplinary approaches.
Dr. Radosław Starosta
Guest Editor
Manuscript Submission Information
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Keywords
- medicinal inorganic chemistry
- medicinal coordination chemistry
- metal based drugs
- transition metal complexes
- coordination compounds
- antifungal properties
- antibacterial properties
- anticancer properties
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