Targeting p53 by Small Molecules: Application in Oncology

Dear Colleagues,

The tumor suppressor protein p53, often referred as the “guardian of the genome”, is among the most privileged targets in anticancer therapy due to its key role in virtually all cancer hallmarks. In most human tumors, the p53 tumor suppressor function is inactivated, through either mutation in the TP53 gene or via negative regulators (e.g., MDM2 and MDMX). Several small-molecule activators of wild-type p53 function have been developed through the inhibition of MDM2, and some have reached clinical trials. However, there is still a limited number of small molecules that can reactivate mutant p53 function, as well as dual inhibitors of MDM2 and MDMX. In this Special Issue on “Targeting p53 with small molecules: application in oncology”, we aim to cover original reviews and research articles focused on new small-molecule p53 activators for anticancer therapy and address the distinct strategies for restoring protein function.

Dr. Maria M. M. Santos
Prof. Dr. Lucília Saraiva
Guest Editors

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