Pharmaceuticals, Volume 12, Issue 4 (December 2019) – 46 articles
Cover Story (view full-size image):
Among the known metal-containing drugs, ruthenium(III) complexes have emerged for their promising anti-cancer properties, leading to a few candidates in advanced clinical trials. This review highlights the unique role of Ru(III)-complexes in the current panorama of anticancer agents, with particular emphasis on Ru-containing nanoformulations that incorporate the Ru(III) complexes into suitable nanocarriers enabling improved bioavailability and pharmacokinetic properties. Preclinical evaluation of these nanoaggregates is discussed with a special focus on the investigation of their mechanism of action at a molecular level, highlighting their pharmacological potential in tumor disease models and value for biomedical applications. View this paper
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