A Decade of Antifungal Leads from Natural Products: 2010–2019
by
Mohammed Aldholmi 1,2
, Pascal Marchand 3, Isabelle Ourliac-Garnier 3, Patrice Le Pape 3 and A. Ganesan 2,*
Mohammed Aldholmi 1,2, Pascal Marchand 3, Isabelle Ourliac-Garnier 3, Patrice Le Pape 3 and A. Ganesan 2,*
1
Department of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia
2
School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
3
Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000 Nantes, France
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(4), 182; https://doi.org/10.3390/ph12040182
Received: 29 November 2019 / Revised: 9 December 2019 / Accepted: 10 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Recent Contributions in Medicinal Chemistry Within European GP2A Network)
In this review, we discuss novel natural products discovered within the last decade that are reported to have antifungal activity against pathogenic species. Nearly a hundred natural products were identified that originate from bacteria, algae, fungi, sponges, and plants. Fungi were the most prolific source of antifungal compounds discovered during the period of review. The structural diversity of these antifungal leads encompasses all the major classes of natural products including polyketides, shikimate metabolites, terpenoids, alkaloids, and peptides.
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Keywords:
fungal pathogens; antifungal agents; natural products
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MDPI and ACS Style
Aldholmi, M.; Marchand, P.; Ourliac-Garnier, I.; Le Pape, P.; Ganesan, A. A Decade of Antifungal Leads from Natural Products: 2010–2019. Pharmaceuticals 2019, 12, 182.
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