Special Issue "Photodynamic Therapy 2019"

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Prof. Serge Mordon

Image assisted laser therapies for oncology" Lille, France
Website 1 | Website 2 | E-Mail
Interests: photodynamic therapy; cancer; clinical evaluation; photosensitizer; dosimetry; Fluorescencer; Dosimetry; Fluorescence

Special Issue Information

Dear Colleagues,

Photodynamic therapy (PDT) is a light-based photochemistry process. The illumination of a photoactivatable molecule (also called photosensitizer) with visible or near infrared light produces reactive oxygen toxic species to destroy tumor cells. This treatment modality leads to highly targeted actions, because reactive oxygen species are produced only where light is applied. Light is not harmful, nor is the photoactivable molecule. Only the combination of three elements (photosensitizer, oxygen, and light) is required to induce photo-oxidation reactions. PDT has proven to be a promising modality in many medical applications including cutaneous condition, infectious diseases, and various cancers at different stages.

The journal Pharmaceuticals invites both reviews and original articles shedding light on the challenges and opportunities of the development of innovative solutions for photodynamic therapy. Topics include selective photoactivatable molecules targeting receptors over-expressed into tumors membranes and/or on neovessels; molecules exhibiting red shifted absorption for better penetration of light into the tissues, photobactericidal agents, theranostics, and photodiagnosis. Reviews and original articles dealing with PDT-associated immunotherapy , new radiation systems such as X-rays, or new devices allowing for better illumination and /or dosimetry are also welcome.

Prof. Serge Mordon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photodynamic therapy
  • photosensitizers
  • photodiagnosis
  • cells
  • receptors
  • antimicrobial photodynamic therapy
  • fluorescence
  • X-rays
  • immunomodulation
  • light
  • dosimetry

Published Papers (1 paper)

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Research

Open AccessArticle Raman Microspectroscopy as a Tool to Elucidate the Efficacy of Topical Formulations Containing Curcumin
Pharmaceuticals 2019, 12(1), 44; https://doi.org/10.3390/ph12010044
Received: 22 February 2019 / Revised: 17 March 2019 / Accepted: 19 March 2019 / Published: 23 March 2019
PDF Full-text (3500 KB) | HTML Full-text | XML Full-text
Abstract
The success of the onychomycosis treatment is directly associated with factors such as the choice of the medication, the administration route, and the pharmaceutical formulation. Photodynamic therapy (PDT) is an emerging and promising technique indicated for onychomycosis treatment. For this application, the main [...] Read more.
The success of the onychomycosis treatment is directly associated with factors such as the choice of the medication, the administration route, and the pharmaceutical formulation. Photodynamic therapy (PDT) is an emerging and promising technique indicated for onychomycosis treatment. For this application, the main challenge is the efficient delivery of the photosensitizer (PS). Curcumin is widely used as a PS, however it is an unstable molecule and it is a challenge to develop a formulation with good penetration into the nail plate, maintaining the stability of curcumin. In this study, the molecular mechanisms underlying the efficacy of two topical formulations containing curcumin used in a clinical trial for onychomycosis treatment were analyzed by Raman microspectroscopy. It is shown that curcumin is present in both formulations in aggregated and non-aggregated states, and in aggregates it is present in different conformations, depending on the interaction with the solvent. This proves to be critical for efficient and uniform PS delivery to the nail and its complete use during the treatment. These analyses are showing how promising Raman microspectroscopy is in understanding the molecular mechanisms of the efficiency of photosensitizers and are helping to improve the development of pharmaceutical formulations. Full article
(This article belongs to the Special Issue Photodynamic Therapy 2019)
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