Topical Collection "Protein Kinases and Cancer"
Interests: protein kinases; protein kinase CK2; prostate cancer; androgens; cancer; head and neck cancer; signaling; protein kinases as targets for therapy; cancer therapy; nuclear matrix; chromatin; intracellular shuttling; apoptosis; mitochondria; cell death; cell calcium
Interests: CK2; CDK11; kinase; Cyclins and CDKs; prostate cancer; breast cancer; melanoma; transcription; cell cycle
During the latter part of the twentieth century, it has continuously been recognized that protein kinases represent a large group of enzymes involved in the phosphorylation of proteins at various sites, thereby altering their functional activities. Protein phosphorylation has emerged as a major post-translation modification encountered by proteins occurring in normal, as well as in abnormal, cell functions. Virtually every aspect of biology is affected by activity of protein kinases. Diverse protein kinases modify proteins largely at serine, threonine, and tyrosine, although other phosphorylation sites are also known. Importantly, a protein may be modified by several protein kinases at the same sites, as well as at multiple sites by different kinases, thereby resulting in complex regulation of the function of a particular protein.
Because of the vast involvement of protein kinases in cell biological functions and their role in various disease states, it stands to reason that protein kinases have attracted much attention as possible targets for therapeutic intervention. In this regard, the role of dysregulated function of protein kinases in cancer has attracted particular consideration and there is a large body of ongoing investigations in this subject area as many different protein kinases are implicated in cancer development and survival. The involvement of protein kinases in cancer is also of focal interest because they serve as existing and potential targets for cancer therapy, and this is also a highly active area of research.
The present Special Issue of Pharmaceuticals is specially dedicated to “Protein Kinases and Cancer”, and represents a compendium of manuscripts and review articles involving different protein kinases with respect to their biological function in various cancers and their potential as therapeutic targets. Pharmaceuticals has previously published a Special Issue dealing with Protein Kinase CK2 and Cancer; you may refer to:https://www.mdpi.com/journal/pharmaceuticals/special_issues/protein_kinase_CK2. However, the present issue includes a broader range of topics covering Protein Kinases and Cancer. We sincerely hope that you will be able to contribute a research manuscript or review article dealing with your research in this area of investigation. The quality of the publications will be ensured by peer review of all the manuscripts prior to their publication.
We look forward to your participation in this endeavor.
Prof. Dr. Khalil Ahmed
Dr. Janeen Trembley
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Protein kinases
- Cancer biology
- Cancer therapy
- Protein kinases as target for cancer therapy
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