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Open AccessCommunication

Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines

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Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy
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Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90133 Palermo, Italy
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(4), 161; https://doi.org/10.3390/ph12040161
Received: 9 October 2019 / Revised: 21 October 2019 / Accepted: 23 October 2019 / Published: 26 October 2019
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original procedure that regards the condensation of benzenesulfenic acid onto the nucleophilic central carbon of the curcumin skeleton. We analyzed cytotoxic effects of such derivatives on two TNBC (triple negative breast cancer) cell lines, SUM 149 and MDA-MB-231, but only three of them showed an IC50 in a lower micromolar range with respect to curcumin. We also focused on these three derivatives that in both cell lines exhibited a higher or at least equivalent pro-apoptotic effect than curcumin. The analysis of molecular mechanisms of action of the curcumin derivatives under study has highlighted that they decreased NF-κB transcriptional factor activity, and consequently the expression of some NF-κB targets. Our data confirmed once again that curcumin may represent a very good lead compound to design analogues with higher antitumor capacities and able to overcome drug resistance with respect to conventional ones, even in tumors difficult to treat as TNBC. View Full-Text
Keywords: antiproliferative activity; prooxidant activity; antioxidant activity; pro-apoptotic activity; NF-κB inhibition; sulfenic acid antiproliferative activity; prooxidant activity; antioxidant activity; pro-apoptotic activity; NF-κB inhibition; sulfenic acid
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Bonaccorsi, P.M.; Labbozzetta, M.; Barattucci, A.; Salerno, T.M.G.; Poma, P.; Notarbartolo, M. Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines. Pharmaceuticals 2019, 12, 161.

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