Next Article in Journal
Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
Previous Article in Journal
Computer-Assisted and Data Driven Approaches for Surveillance, Drug Discovery, and Vaccine Design for the Zika Virus
Previous Article in Special Issue
Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus
Open AccessReview

Neural Predictors of the Antidepressant Placebo Response

1
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
2
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
3
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
*
Author to whom correspondence should be addressed.
Both authors contributed equally.
Pharmaceuticals 2019, 12(4), 158; https://doi.org/10.3390/ph12040158
Received: 30 September 2019 / Revised: 15 October 2019 / Accepted: 18 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Antidepressants: Mechanistic Insights and Future Directions)
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. View Full-Text
Keywords: placebo response; antidepressant; neural predictors placebo response; antidepressant; neural predictors
Show Figures

Figure 1

MDPI and ACS Style

Rette, D.; McDonald, E.; Iosifescu, D.V.; Collins, K.A. Neural Predictors of the Antidepressant Placebo Response. Pharmaceuticals 2019, 12, 158.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop