Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment
by
Isabela Pereira Gomes 1,†
, Jaqueline Aparecida Duarte 1,†, Ana Luiza Chaves Maia 1, Domenico Rubello 2,*, Danyelle M. Townsend 3, André Luís Branco de Barros 1 and Elaine Amaral Leite 1,*
Isabela Pereira Gomes 1,†, Jaqueline Aparecida Duarte 1,†, Ana Luiza Chaves Maia 1, Domenico Rubello 2,*, Danyelle M. Townsend 3, André Luís Branco de Barros 1 and Elaine Amaral Leite 1,*
1
Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31279-901 Belo Horizonte, Brazil
2
Department of Nuclear Medicine, Radiology, Neuroradiology, Medical Physics, Clinical Laboratory, Microbiology, Pathology, Trasfusional Medicine, Santa Maria della Misericordia Hospital, 45100 Rovigo, Italy
3
Department of Drug Discovery and Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2019, 12(4), 171; https://doi.org/10.3390/ph12040171
Received: 9 October 2019 / Revised: 20 November 2019 / Accepted: 21 November 2019 / Published: 25 November 2019
(This article belongs to the Special Issue The Future Direction of Radiopharmaceutical Development for Cancer Theranostics)
Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use.
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Keywords:
hyperthermia; thermosensitive systems; cancer treatment
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MDPI and ACS Style
Pereira Gomes, I.; Aparecida Duarte, J.; Chaves Maia, A.L.; Rubello, D.; Townsend, D.M.; Branco de Barros, A.L.; Leite, E.A. Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment. Pharmaceuticals 2019, 12, 171.
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