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Open AccessReview

Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment

1
Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31279-901 Belo Horizonte, Brazil
2
Department of Nuclear Medicine, Radiology, Neuroradiology, Medical Physics, Clinical Laboratory, Microbiology, Pathology, Trasfusional Medicine, Santa Maria della Misericordia Hospital, 45100 Rovigo, Italy
3
Department of Drug Discovery and Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceuticals 2019, 12(4), 171; https://doi.org/10.3390/ph12040171
Received: 9 October 2019 / Revised: 20 November 2019 / Accepted: 21 November 2019 / Published: 25 November 2019
Conventional chemotherapy regimens have limitations due to serious adverse effects. Targeted drug delivery systems to reduce systemic toxicity are a powerful drug development platform. Encapsulation of antitumor drug(s) in thermosensitive nanocarriers is an emerging approach with a promise to improve uptake and increase therapeutic efficacy, as they can be activated by hyperthermia selectively at the tumor site. In this review, we focus on thermosensitive nanosystems associated with hyperthermia for the treatment of cancer, in preclinical and clinical use. View Full-Text
Keywords: hyperthermia; thermosensitive systems; cancer treatment hyperthermia; thermosensitive systems; cancer treatment
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MDPI and ACS Style

Pereira Gomes, I.; Aparecida Duarte, J.; Chaves Maia, A.L.; Rubello, D.; Townsend, D.M.; Branco de Barros, A.L.; Leite, E.A. Thermosensitive Nanosystems Associated with Hyperthermia for Cancer Treatment. Pharmaceuticals 2019, 12, 171.

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