You are currently viewing a new version of our website. To view the old version click .

International Journal of Molecular Sciences, Volume 24, Issue 10

May-2 2023 - 649 articles

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story: Osteosarcoma (OS) is the most common primary malignant bone tumor and its etiology has been associated with disfunction in osteogenic differentiation. Conventional and synchrotron X-rays techniques were used to study the genesis and evolution of mineral depositions in a human OS cell line exposed to an osteogenic cocktail. After treatment, the partial restoration of physiological biomineralization, together with a mitochondria-driven mechanism for calcium transport, was observed. During differentiation, the mitochondria showed a change in morphology, possibly linked to a switch in the cell energy metabolism. These findings add a dowel to the genesis of OS, providing new insights into the development of therapeutic strategies that can restore the physiological mineralization in OS cells. View this paper

Articles (649)

  • Article
  • Open Access
4 Citations
2,861 Views
17 Pages

Clinical, Genetic, and Histological Characterization of Patients with Rare Neuromuscular and Mitochondrial Diseases Presenting with Different Cardiomyopathy Phenotypes

  • Emanuele Monda,
  • Michele Lioncino,
  • Martina Caiazza,
  • Vincenzo Simonelli,
  • Claudia Nesti,
  • Marta Rubino,
  • Alessia Perna,
  • Alfredo Mauriello,
  • Alberta Budillon and
  • Vincenzo Pota
  • + 9 authors

Cardiomyopathies are mostly determined by genetic mutations affecting either cardiac muscle cell structure or function. Nevertheless, cardiomyopathies may also be part of complex clinical phenotypes in the spectrum of neuromuscular (NMD) or mitochond...

  • Article
  • Open Access
2 Citations
4,501 Views
21 Pages

An Optimized Flow Cytometric Method to Demonstrate the Differentiation Stage-Dependent Ca2+ Flux Responses of Peripheral Human B Cells

  • Anna Bajnok,
  • Timea Serény-Litvai,
  • Viktória Temesfői,
  • Jasper Nörenberg,
  • Róbert Herczeg,
  • Ambrus Kaposi,
  • Timea Berki and
  • Emese Mezosi

Calcium (Ca2+) flux acts as a central signaling pathway in B cells, and its alterations are associated with autoimmune dysregulation and B-cell malignancies. We standardized a flow-cytometry-based method using various stimuli to investigate the Ca2+...

  • Article
  • Open Access
8 Citations
3,286 Views
13 Pages

Kidney-Related Function of Mitochondrial Protein Mitoregulin

  • Olga A. Averina,
  • Oleg A. Permyakov,
  • Mariia A. Emelianova,
  • Ekaterina A. Guseva,
  • Olga O. Grigoryeva,
  • Maxim L. Lovat,
  • Anna E. Egorova,
  • Andrei V. Grinchenko,
  • Vadim V. Kumeiko and
  • Maria V. Marey
  • + 4 authors

A small protein, Mitoregulin (Mtln), localizes in mitochondria and contributes to oxidative phosphorylation and fatty acid metabolism. Mtln knockout mice develop obesity on a high-fat diet, demonstrating elevated cardiolipin damage and suboptimal cre...

  • Article
  • Open Access
11 Citations
3,783 Views
17 Pages

Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson’s Disease

  • Alena E. Kopytova,
  • George N. Rychkov,
  • Alexander A. Cheblokov,
  • Elena V. Grigor’eva,
  • Mikhail A. Nikolaev,
  • Elena S. Yarkova,
  • Diana A. Sorogina,
  • Farid M. Ibatullin,
  • Galina V. Baydakova and
  • Artem D. Izyumchenko
  • + 9 authors

Mutations in the GBA1 gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), cause Gaucher disease (GD) and are the most common genetic risk factor for Parkinson’s disease (PD). Pharmacological chaperones (PCs) are being developed as a...

  • Article
  • Open Access
7 Citations
3,013 Views
24 Pages

Prostate cancer (PCa) is one of the most common malignancies among men worldwide. Inevitably, all advanced PCa patients develop metastatic castration-resistant prostate cancer (mCRPC), an aggressive phase of the disease. Treating mCRPC is challenging...

  • Article
  • Open Access
22 Citations
3,249 Views
25 Pages

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors

  • Lamya H. Al-Wahaibi,
  • Hesham A. Abou-Zied,
  • Eman A. M. Beshr,
  • Bahaa G. M. Youssif,
  • Alaa M. Hayallah and
  • Mohamed Abdel-Aziz

Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have been developed. The target compounds were synthesized and tested in vitro against four cancer cell lines. Compounds 12, 15, and 17 demonstrated strong antiprolife...

  • Review
  • Open Access
13 Citations
7,323 Views
15 Pages

A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant

  • Jukito Sonoda,
  • Izuru Mizoguchi,
  • Shinya Inoue,
  • Aruma Watanabe,
  • Ami Sekine,
  • Miu Yamagishi,
  • Satomi Miyakawa,
  • Natsuki Yamaguchi,
  • Eri Horio and
  • Yasuhiro Katahira
  • + 4 authors

Current worldwide mRNA vaccination against SARS-CoV-2 by intramuscular injection using a needled syringe has greatly protected numerous people from COVID-19. An intramuscular injection is generally well tolerated, safer and easier to perform on a lar...

  • Article
  • Open Access
6 Citations
4,421 Views
15 Pages

Methionine adenosyl transferases (MATs) catalyze the synthesis of the biological methyl donor adenosylmethionine (SAM). Dysregulation of MATs has been associated with carcinogenesis in humans. We previously found that downregulation of the MAT1A gene...

  • Article
  • Open Access
19 Citations
2,621 Views
21 Pages

Haloxylon ammodendron and Haloxylon persicum, as typical desert plants in arid areas, show strong drought tolerance and environmental adaptability and are therefore ideal model plants for studying the molecular mechanisms of drought tolerance. A meta...

  • Article
  • Open Access
5 Citations
2,665 Views
15 Pages

[3+2] cycloaddition reactions play a crucial role in synthesizing complex organic molecules and have significant applications in drug discovery and materials science. In this study, the [3+2] cycloaddition (32CA) reactions of N-methyl-C-4-methyl phen...

of 65