International Journal of Molecular Sciences, Volume 24, Issue 10
May-2 2023 - 649 articles
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Cover Story: Osteosarcoma (OS) is the most common primary malignant bone tumor and its etiology has been associated with disfunction in osteogenic differentiation. Conventional and synchrotron X-rays techniques were used to study the genesis and evolution of mineral depositions in a human OS cell line exposed to an osteogenic cocktail. After treatment, the partial restoration of physiological biomineralization, together with a mitochondria-driven mechanism for calcium transport, was observed. During differentiation, the mitochondria showed a change in morphology, possibly linked to a switch in the cell energy metabolism. These findings add a dowel to the genesis of OS, providing new insights into the development of therapeutic strategies that can restore the physiological mineralization in OS cells. View this paper