Next Article in Journal
Complex Formation of an RNA Aptamer with a Part of HIV-1 Tat through Induction of Base Triples in Living Human Cells Proven by In-Cell NMR
Next Article in Special Issue
Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel
Previous Article in Journal
Rare Diseases: Implementation of Molecular Diagnosis, Pathogenesis Insights and Precision Medicine Treatment
Previous Article in Special Issue
Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 10
10.3390/ijms24109067
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease

by
Daniela Baracaldo-Santamaría
1,
Sara Sofia Avendaño-Lopez
1,
Daniel Felipe Ariza-Salamanca
2,
Mateo Rodriguez-Giraldo
3,
Carlos A. Calderon-Ospina
1,4,
Rodrigo E. González-Reyes
3 and
Mauricio O. Nava-Mesa
3,*
1
Pharmacology Unit, Department of Biomedical Sciences, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia
2
Medical and Health Sciences Education Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia
3
Grupo de Investigación en Neurociencias (NeURos), Centro de Neurociencias Neurovitae-UR, Instituto de Medicina Traslacional (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia
4
Grupo de Investigación en Ciencias Biomédicas Aplicadas (UR Biomed), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(10), 9067; https://doi.org/10.3390/ijms24109067
Submission received: 27 March 2023 / Revised: 2 May 2023 / Accepted: 5 May 2023 / Published: 22 May 2023
(This article belongs to the Special Issue Recent Advances in Alzheimer’s Disease)
Browse Figures
Versions Notes

Abstract

Alzheimer’s disease (AD) is a chronic neurodegenerative disease and the most frequent cause of progressive dementia in senior adults. It is characterized by memory loss and cognitive impairment secondary to cholinergic dysfunction and N-methyl-D-aspartate (NMDA)-mediated neurotoxicity. Intracellular neurofibrillary tangles, extracellular plaques composed of amyloid-β (Aβ), and selective neurodegeneration are the anatomopathological hallmarks of this disease. The dysregulation of calcium may be present in all the stages of AD, and it is associated with other pathophysiological mechanisms, such as mitochondrial failure, oxidative stress, and chronic neuroinflammation. Although the cytosolic calcium alterations in AD are not completely elucidated, some calcium-permeable channels, transporters, pumps, and receptors have been shown to be involved at the neuronal and glial levels. In particular, the relationship between glutamatergic NMDA receptor (NMDAR) activity and amyloidosis has been widely documented. Other pathophysiological mechanisms involved in calcium dyshomeostasis include the activation of L-type voltage-dependent calcium channels, transient receptor potential channels, and ryanodine receptors, among many others. This review aims to update the calcium-dysregulation mechanisms in AD and discuss targets and molecules with therapeutic potential based on their modulation.
Keywords: Alzheimer’s disease; dementia; calcium channels; calcium; therapy; calcium homeostasis Alzheimer’s disease; dementia; calcium channels; calcium; therapy; calcium homeostasis

Share and Cite

MDPI and ACS Style

Baracaldo-Santamaría, D.; Avendaño-Lopez, S.S.; Ariza-Salamanca, D.F.; Rodriguez-Giraldo, M.; Calderon-Ospina, C.A.; González-Reyes, R.E.; Nava-Mesa, M.O. Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 9067. https://doi.org/10.3390/ijms24109067

AMA Style

Baracaldo-Santamaría D, Avendaño-Lopez SS, Ariza-Salamanca DF, Rodriguez-Giraldo M, Calderon-Ospina CA, González-Reyes RE, Nava-Mesa MO. Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease. International Journal of Molecular Sciences. 2023; 24(10):9067. https://doi.org/10.3390/ijms24109067

Chicago/Turabian Style

Baracaldo-Santamaría, Daniela, Sara Sofia Avendaño-Lopez, Daniel Felipe Ariza-Salamanca, Mateo Rodriguez-Giraldo, Carlos A. Calderon-Ospina, Rodrigo E. González-Reyes, and Mauricio O. Nava-Mesa. 2023. "Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease" International Journal of Molecular Sciences 24, no. 10: 9067. https://doi.org/10.3390/ijms24109067

APA Style

Baracaldo-Santamaría, D., Avendaño-Lopez, S. S., Ariza-Salamanca, D. F., Rodriguez-Giraldo, M., Calderon-Ospina, C. A., González-Reyes, R. E., & Nava-Mesa, M. O. (2023). Role of Calcium Modulation in the Pathophysiology and Treatment of Alzheimer’s Disease. International Journal of Molecular Sciences, 24(10), 9067. https://doi.org/10.3390/ijms24109067

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop