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International Journal of Molecular Sciences, Volume 17, Issue 7

July 2016 - 200 articles

Cover Story: The image represents a silkworm lightened by an innovative biopolymeric light-diffusing fiber which is obtained from the “silkworm gut” as is described in the manuscript. The neon glow of the fiber is red because it is illuminated by a red laser, which is proved to have a stimulatory effect on cells. This work describes how light was efficiently diffused along the fiber wall, promoting a significant increment in the cell metabolism after the irradiation. Thus a new approach to the delivery of light in deeper tissues is possible.
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Articles (200)

  • Article
  • Open Access
12 Citations
6,141 Views
9 Pages

Prolonged Starvation Causes Up-Regulation of AQP1 in Adipose Tissue Capillaries of AQP7 Knock-Out Mice

  • Mariusz T. Skowronski,
  • Agnieszka Skowronska,
  • Aleksandra Rojek,
  • Michal K. Oklinski and
  • Søren Nielsen

Aquaporins (AQPs) are membrane proteins involved in the regulation of cellular transport and the balance of water and glycerol and cell volume in the white adipose tissue (WAT). In our previous study, we found the co-expression of the AQP1 water chan...

  • Article
  • Open Access
10 Citations
6,291 Views
17 Pages

De Novo Assembly and Characterization of the Transcriptome of Grasshopper Shirakiacris shirakii

  • Zhongying Qiu,
  • Fei Liu,
  • Huimeng Lu,
  • Hao Yuan,
  • Qin Zhang and
  • Yuan Huang

Background: The grasshopper Shirakiacris shirakii is an important agricultural pest and feeds mainly on gramineous plants, thereby causing economic damage to a wide range of crops. However, genomic information on this species is extremely limited thu...

  • Article
  • Open Access
14 Citations
6,163 Views
13 Pages

Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease

  • Jian Guo,
  • Yang Li,
  • Yi-Hong Ren,
  • Zhijun Sun,
  • Jie Dong,
  • Han Yan,
  • Yujun Xu,
  • Dao Wen Wang,
  • Gu-Yan Zheng and
  • Jie Du
  • + 1 author

Mutations in the genes low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) and myocyte enhancer factor 2A (MEF2A) were reported in families with coronary artery disease (CAD). We intend to determine the mutational spectrum of these genes...

  • Article
  • Open Access
19 Citations
8,415 Views
12 Pages

Increasing evidences show that XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6) was upregulated and involved in tumor growth in several tumor types. However, the correlation of XRCC6 and human osteosarcoma (OS) is still...

  • Review
  • Open Access
20 Citations
6,925 Views
15 Pages

The induction of resistance mechanisms represents an important problem for the targeted therapy of patients with non-small-cell lung cancer (NSCLC). The best-known resistance mechanism induced during treatment with epidermal growth factor receptor (E...

  • Article
  • Open Access
67 Citations
7,459 Views
10 Pages

Neuroprotective Effect of Salvianolic Acids against Cerebral Ischemia/Reperfusion Injury

  • Shuai Hou,
  • Ming-Ming Zhao,
  • Ping-Ping Shen,
  • Xiu-Ping Liu,
  • Yuan Sun and
  • Jia-Chun Feng

This study investigated the neuroprotective effect of salvianolic acids (SA) against ischemia/reperfusion (I/R) injury, and explored whether the neuroprotection was dependent on mitochondrial connexin43 (mtCx43) via the phosphatidylinositol 3-kinase/...

  • Article
  • Open Access
79 Citations
19,410 Views
13 Pages

Orofacial Manifestations and Temporomandibular Disorders of Systemic Scleroderma: An Observational Study

  • Vito Crincoli,
  • Laura Fatone,
  • Margherita Fanelli,
  • Rossana Patricia Rotolo,
  • Angela Chialà,
  • Gianfranco Favia and
  • Giovanni Lapadula

Scleroderma is a disorder involving oral and facial tissues, with skin hardening, thin lips, deep wrinkles, xerostomia, tongue rigidity, and microstomia. The aim of this study was to investigate the prevalence of oral manifestations and temporomandib...

  • Article
  • Open Access
14 Citations
7,092 Views
14 Pages

Revisiting the Lamotrigine-Mediated Effect on Hippocampal GABAergic Transmission

  • Yu-Yin Huang,
  • Yu-Chao Liu,
  • Cheng-Ta Lee,
  • Yen-Chu Lin,
  • Mong-Lien Wang,
  • Yi-Ping Yang,
  • Kaung-Yi Chang and
  • Shih-Hwa Chiou

Lamotrigine (LTG) is generally considered as a voltage-gated sodium (Nav) channel blocker. However, recent studies suggest that LTG can also serve as a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel enhancer and can increase the ex...

  • Article
  • Open Access
24 Citations
7,806 Views
14 Pages

Nutritional Strategies for the Individualized Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) Based on the Nutrient-Induced Insulin Output Ratio (NIOR)

  • Ewa Stachowska,
  • Karina Ryterska,
  • Dominika Maciejewska,
  • Marcin Banaszczak,
  • Piotr Milkiewicz,
  • Małgorzata Milkiewicz,
  • Izabela Gutowska,
  • Piotr Ossowski,
  • Małgorzata Kaczorowska and
  • Dominika Jamioł-Milc
  • + 4 authors

Nutrients play a fundamental role as regulators of the activity of enzymes involved in liver metabolism. In the general population, the action of nutrients may be affected by gene polymorphisms. Therefore, individualization of a diet for individuals...

  • Review
  • Open Access
78 Citations
14,124 Views
29 Pages

Matrix Metalloproteinases in Non-Neoplastic Disorders

  • Akinori Tokito and
  • Michihisa Jougasaki

The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and they and their substrates are widely expressed in many tissues. Recent gr...

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Int. J. Mol. Sci. - ISSN 1422-0067