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Int. J. Mol. Sci. 2016, 17(7), 1142;

Silkworm Gut Fiber of Bombyx mori as an Implantable and Biocompatible Light-Diffusing Fiber

Department of Biotechnology, Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario (IMIDA), Murcia 30150, Spain
Departamento de Electromagnetismo y Electrónica, Universidad de Murcia, Murcia 30003, Spain
Biomaterials & Tissue Engineering Unit & Orthopedic Surgery Service, V. Arrixaca University Hospital, Murcia 30120, Spain
Department of Health Sciences, UCAM-Catholic University of Murcia, Murcia 30107, Spain
Author to whom correspondence should be addressed.
Academic Editor: John G. Hardy
Received: 14 June 2016 / Revised: 8 July 2016 / Accepted: 9 July 2016 / Published: 16 July 2016
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
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This work describes a new approach to the delivery of light in deeper tissues, through a silk filament that is implantable, biocompatible, and biodegradable. In the present work, silkworm gut fibers (SGFs) of Bombyx mori L., are made by stretching the silk glands. Morphological, structural, and optical properties of the fibers have been characterized and the stimulatory effect of red laser light diffused from the fiber was assayed in fibroblast cultures. SGFs are formed by silk fibroin (SF) mainly in a β-sheet conformation, a stable and non-soluble state in water or biological fluids. The fibers showed a high degree of transparency to visible and infrared radiation. Using a red laser (λ = 650 nm) as source, the light was efficiently diffused along the fiber wall, promoting a significant increment in the cell metabolism 5 h after the irradiation. SGFs have shown their excellent properties as light-diffusing optical fibers with a stimulatory effect on cells. View Full-Text
Keywords: silkworm gut fiber; biocompatibility; light-diffusing optical fiber; silk fibroin silkworm gut fiber; biocompatibility; light-diffusing optical fiber; silk fibroin

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Cenis, J.L.; Aznar-Cervantes, S.D.; Lozano-Pérez, A.A.; Rojo, M.; Muñoz, J.; Meseguer-Olmo, L.; Arenas, A. Silkworm Gut Fiber of Bombyx mori as an Implantable and Biocompatible Light-Diffusing Fiber. Int. J. Mol. Sci. 2016, 17, 1142.

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