The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome
AbstractThis study was designed to investigate the role of aquaporin1 (AQP1) in the pathologic process of pulmonary edema induced by fat embolism syndrome (FES) and the effects of a free fatty acid (FFA) mixture on AQP1 expression in pulmonary microvascular endothelial cells (PMVECs). In vivo, edema was more serious in FES mice compared with the control group. The expression of AQP1 and the wet-to-dry lung weight ratio (W/D) in the FES group were significantly increased compared with the control group. At the same time, inhibition of AQP1 decreased the pathological damage resulting from pulmonary edema. Then we performed a study in vitro to investigate whether AQP1 was induced by FFA release in FES. The mRNA and protein level of AQP1 were increased by FFAs in a dose- and time-dependent manner in PMVECs. In addition, the up-regulation of AQP1 was blocked by the inhibitor of p38 kinase, implicating the p38 MAPK pathway as involved in the FFA-induced AQP1 up-regulation in PMVECs. Our results demonstrate that AQP1 may play important roles in pulmonary edema induced by FES and can be regarded as a new therapy target for treatment of pulmonary edema induced by FES. View Full-Text
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Zhang, Y.; Tian, K.; Wang, Y.; Zhang, R.; Shang, J.; Jiang, W.; Wang, A. The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome. Int. J. Mol. Sci. 2016, 17, 1183.
Zhang Y, Tian K, Wang Y, Zhang R, Shang J, Jiang W, Wang A. The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome. International Journal of Molecular Sciences. 2016; 17(7):1183.Chicago/Turabian Style
Zhang, Yiwei; Tian, Kun; Wang, Yan; Zhang, Rong; Shang, Jiawei; Jiang, Wei; Wang, Aizhong. 2016. "The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome." Int. J. Mol. Sci. 17, no. 7: 1183.
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