Table of Contents
Int. J. Mol. Sci., Volume 17, Issue 3 (March 2016)
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Cover Story (view full-size image) Matrix metalloproteinase 13 (MMP-13) is a validated therapeutic target for a multitude of severe [...] Read more. Matrix metalloproteinase 13 (MMP-13) is a validated therapeutic target for a multitude of severe diseases. In this study we performed a structure-based design on a weak allosteric inhibitor of MMP-13, in order to develop dual binding mode inhibitors with improved potency and drug-like properties, by targeting the catalytic zinc (II) ion while still populating the allosteric selectivity loop. The cover picture depicts the design concept of our study. For details concerning the selection of zinc-binding groups, the organic synthesis of the inhibitors and their biological evaluation. View this article.