Special Issue "Molecular and Cellular Mechanisms of Chemical-Induced Toxicity and Carcinogenesis"
Deadline for manuscript submissions: closed (31 January 2016)
Prof. Dr. Paul B. Tchounwou
Department of Biology, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA
Fax: +1 601 979 2349
Acute and/or chronic exposure to many environmental compounds and chemotherapeutic drugs has been associated with significant adverse effects in humans and experimental animals. A comprehensive analysis of published data indicates that such exposure induces toxicity to many organs and tissues, including the cardiovascular, hepatic, excretory, developmental, nervous, respiratory, dermatological, digestive, hematologic, muscular, and/or reproductive systems; these effects depend on the type and species of chemical, exposure dose, frequency and route, age, gender, nutritional status, and genetic make-up. For many of these chemicals, both epidemiological studies and experimental investigations have demonstrated strong correlations between exposure and the increase in cancer incidence. Although scientific advances have significantly contributed to our understanding of specific, chemically-induced disease end-points, the detailed molecular and cellular mechanisms of toxicity and carcinogenesis are not fully elucidated. Understanding the basic and underlying mechanisms of xenobiotic-induced toxicity and carcinogenesis at the cellular and molecular levels is essential for identifying new targets and developing new therapeutic strategies for disease prevention and control. This Special Issue will focus on the publication of novel research on the mechanisms of chemical toxicity and carcinogenesis. Both original manuscripts and critical reviews examining the cellular, molecular, genetic, immunologic, necrotic, apoptotic, and/or signal transduction mechanisms involved in the toxico-pathological or pharmacological effects of xenobiotic compounds on various organ systems and tissues, are welcome.
Prof. Dr. Paul B. Tchounwou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Molecular toxicology, carcinogenesis, therapeutics
- Biomarkers of chemical exposure, susceptibility and effect
- Oxidative stress biomarkers, transcription factors
- Apoptosis and/or necrosis mechanisms
- Cancer induction and cancer treatment
- Cellular signaling and gene expression
- Cellular metabolism and chemical biotransformation