Next Article in Journal
Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging
Next Article in Special Issue
MicroRNAs as Biomarkers for Diagnosis, Prognosis and Theranostics in Prostate Cancer
Previous Article in Journal
Proteomics-Based Analysis of Protein Complexes in Pluripotent Stem Cells and Cancer Biology
Previous Article in Special Issue
MicroRNAs in Osteoclastogenesis and Function: Potential Therapeutic Targets for Osteoporosis
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(3), 424;

Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer

Molecular Pathology Laboratory, Department of Pathology, CEGIN-BIOREN, Universidad de La Frontera, Avenida Alemania 0458, 3th Floor, Temuco 4810296, Chile
School of Health Sciences, Universidad Católica de Temuco, Manuel Montt 56, Temuco 4813302, Chile
Department of Pathology, UC Centre for Investigational Oncology (CITO), Advanced Centre for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Marcoleta 377, 7th Floor, Santiago 8330024, Chile
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Nalini Santanam and William Chi-shing Cho
Received: 1 February 2016 / Revised: 11 March 2016 / Accepted: 16 March 2016 / Published: 22 March 2016
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
Full-Text   |   PDF [854 KB, uploaded 22 March 2016]   |  


Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs’ characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer. View Full-Text
Keywords: microRNAs; drug resistance; gastric cancer microRNAs; drug resistance; gastric cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Riquelme, I.; Letelier, P.; Riffo-Campos, A.L.; Brebi, P.; Roa, J.C. Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer. Int. J. Mol. Sci. 2016, 17, 424.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top