Special Issue "Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes"
Deadline for manuscript submissions: closed (31 December 2016)
Dr. Kotb Abdelmohsen
Laboratory of Molecular Biology and Immunology; National Institute on Aging-Intramural Research Program; National Institutes of Health; Baltimore, MD USA
Interests: cancer; aging; post-transcriptional gene regulation; cell signaling; oxidative stress; RNA-binding proteins; mRNA stability; mRNA translation; long non-coding RNAs; micro-RNA (miRNA)
Post-transcriptional gene regulation by Ribonucleoprotein complexes. Ribonucleoprotein complexes are widely present in eukaryotic cells representing protein interactions with coding and non-coding RNAs. In the last few years we observed a great advance in identifying the precise protein-bound RNA sequences through the technology of RNA sequencing. These interactions are major regulators of post-transcriptional gene expression. They control RNA splicing, mRNA export, stability and translation. They regulate microRNA (miRNA) processing through binding to primary, precursor, and mature sequences. RNA-binding proteins also bind long non-coding RNAs (lncRNAs) to guide them through their interactions with mRNA to regulate mRNA stability or translation.
The goal of this special issue is to introduce the recent advances in the area of post-transcriptional gene regulation through RNA-protein interactions. The issue will generally focus on RNA-binding proteins and their effects on mRNA stability, translation and subcellular localization. The mechanisms and biological consequences of assembly of ribonucleoprotein complexes in which non-coding RNAs (lncRNAs and miRNAs) are the binding partners will be also addressed in this issue. Authors are also encouraged to review the recent progress in large-scale experimental approaches such as deep sequencing of total RNA and PAR-CLIP (photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation) of protein-bound RNAs. It is also important to review the new developments and challenges in computational methods that identify and characterize protein-bound cis-regulatory RNA sequences.
Dr. Kotb Abdelmohsen
Manuscript Submission Information
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- post-transcriptional gene regulation
- RNA-binding proteins
- mRNA stability
- mRNA translation
- RNA metabolism
- RNA export
- long non-coding RNAs
- Micro-RNA (miRNA)
- deep sequencing