Table of Contents
Molecules, Volume 25, Issue 17 (September-1 2020) – 269 articles
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Cover Story (view full-size image) Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) stands out from other plasma membrane lipids as [...] Read more. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) stands out from other plasma membrane lipids as one of the most important regulators of membrane-associated signaling events. PI(4,5)P2 is able to engage in a multitude of simultaneous cellular functions that are temporally and spatially regulated through the presence of localized transient pools of PI(4,5)P2 in the membrane. These pools are crucial for the recruitment, activation, and organization of signaling proteins and consequent regulation of downstream signaling. This review showcases some of the most important molecular and biophysical properties of PI(4,5)P2 as well as their impact on its membrane dynamics, lateral organization, and interactions with other biochemical partners. View this paper.