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Molecules, Volume 25, Issue 17

September-1 2020 - 269 articles

Cover Story: Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) stands out from other plasma membrane lipids as one of the most important regulators of membrane-associated signaling events. PI(4,5)P2 is able to engage in a multitude of simultaneous cellular functions that are temporally and spatially regulated through the presence of localized transient pools of PI(4,5)P2 in the membrane. These pools are crucial for the recruitment, activation, and organization of signaling proteins and consequent regulation of downstream signaling. This review showcases some of the most important molecular and biophysical properties of PI(4,5)P2 as well as their impact on its membrane dynamics, lateral organization, and interactions with other biochemical partners. View this paper.
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Articles (269)

  • Article
  • Open Access
8 Citations
4,893 Views
20 Pages

Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery

  • Blake R. Rushing,
  • Denise L. Rohlik,
  • Sourav Roy,
  • D. Andrew Skaff and
  • Brandon L. Garcia

3 September 2020

The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases. Yet, C1r-targeted therapeutic development is currently under...

  • Review
  • Open Access
9 Citations
4,970 Views
19 Pages

PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives

  • Santosh Reddy Alluri,
  • Sung Won Kim,
  • Nora D. Volkow and
  • Kun-Eek Kil

3 September 2020

Epinephrine (E) and norepinephrine (NE) play diverse roles in our body’s physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and t...

  • Review
  • Open Access
95 Citations
12,309 Views
29 Pages

3 September 2020

The genus Euphorbia is one of the largest genera in the spurge family, with diversity in range, distribution, and morphology. The plant species in this genus are widely used in traditional medicine for the treatment of diseases, ranging from respirat...

  • Article
  • Open Access
5 Citations
3,275 Views
20 Pages

In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained from Boehmeria caudata Sw. Aerial Parts

  • Paula P. de Paiva,
  • Julia H. B. Nunes,
  • Fabiana R. Nonato,
  • Ana L. T. G. Ruiz,
  • Rafael R. T. Zafred,
  • Ilza M. O. Sousa,
  • Márcia Y. Okubo,
  • Daniel F. Kawano,
  • Paula A. Monteiro and
  • Mary A. Foglio
  • + 1 author

3 September 2020

In the context of the cancer-inflammation relationship and the use of natural products as potential antitumor and anti-inflammatory agents, the alkaloid-enriched fraction of Boehmeriacaudata (BcAEF) aerial parts was evaluated. In vitro antiproliferat...

  • Feature Paper
  • Article
  • Open Access
31 Citations
3,776 Views
14 Pages

Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide

  • Khalida Mokhtari,
  • Amalia Pérez-Jiménez,
  • Leticia García-Salguero,
  • José A. Lupiáñez and
  • Eva E. Rufino-Palomares

3 September 2020

Maslinic acid (MA) is a natural triterpene from Olea europaea L. with multiple biological properties. The aim of the present study was to examine MA’s effect on cell viability (by the MTT assay), reactive oxygen species (ROS levels, by flow cyt...

  • Feature Paper
  • Article
  • Open Access
13 Citations
5,039 Views
18 Pages

Colorimetry of Luminescent Lanthanide Complexes

  • Julien Andres and
  • Anne-Sophie Chauvin

3 September 2020

Europium, terbium, dysprosium, and samarium are the main trivalent lanthanide ions emitting in the visible spectrum. In this work, the potential of these ions for colorimetric applications and colour reproduction was studied. The conversion of spectr...

  • Article
  • Open Access
37 Citations
5,827 Views
10 Pages

Enhancing the Performance of Dye Sensitized Solar Cells Using Silver Nanoparticles Modified Photoanode

  • Faizah Saadmim,
  • Taseen Forhad,
  • Ahmed Sikder,
  • William Ghann,
  • Meser M. Ali,
  • Viji Sitther,
  • A. J. Saleh Ahammad,
  • Md. Abdus Subhan and
  • Jamal Uddin

3 September 2020

In this study, silver nanoparticles were synthesized, characterized, and applied to a dye-sensitized solar cell (DSSC) to enhance the efficiency of solar cells. The synthesized silver nanoparticles were characterized with UV–Vis spectroscopy, d...

  • Feature Paper
  • Article
  • Open Access
16 Citations
4,785 Views
23 Pages

Spatial Metagenomics of Three Geothermal Sites in Pisciarelli Hot Spring Focusing on the Biochemical Resources of the Microbial Consortia

  • Roberta Iacono,
  • Beatrice Cobucci-Ponzano,
  • Federica De Lise,
  • Nicola Curci,
  • Luisa Maurelli,
  • Marco Moracci and
  • Andrea Strazzulli

3 September 2020

Terrestrial hot springs are of great interest to the general public and to scientists alike due to their unique and extreme conditions. These have been sought out by geochemists, astrobiologists, and microbiologists around the globe who are intereste...

  • Article
  • Open Access
12 Citations
4,240 Views
21 Pages

3 September 2020

Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition a...

  • Feature Paper
  • Article
  • Open Access
12 Citations
4,615 Views
25 Pages

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

  • Patrick Weber,
  • Martin Thonhofer,
  • Summer Averill,
  • Gideon J. Davies,
  • Andres Gonzalez Santana,
  • Philipp Müller,
  • Seyed A. Nasseri,
  • Wendy A. Offen,
  • Bettina M. Pabst and
  • Eduard Paschke
  • + 9 authors

3 September 2020

Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological ch...

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Molecules - ISSN 1420-3049