- Article
Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery
- Blake R. Rushing,
- Denise L. Rohlik,
- Sourav Roy,
- D. Andrew Skaff and
- Brandon L. Garcia
The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases. Yet, C1r-targeted therapeutic development is currently under...

