Special Issue "Organofluorine Chemistry"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 31 August 2019
Prof. Dr. Loránd Kiss
Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary
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Interests: syntheses of three-dimensional, functionalized small-molecular entities with multiple chiral centers; transformations of beta-amino acid derivatives; synthesis of highly functionalized organofluorine building blocks
Organofluorine chemistry,which represents an expanding field of research in drug design, has generated increasing interest in pharmaceutical research over the past decade. Although fluorinated organic molecules are virtually nonexistent in nature, the number of novel fluorine-containing substances as well as fluorinated drugs is ever increasing. It is expected that fluorinated small-molecular entities (azaheterocycles, functionalized alicycles, amino acids, nucleosides, etc.), as potential bioactive scaffolds or building blocks, will be of high importance in drug research over the coming years. Accordingly, their syntheses and the development of versatile synthetic methods for these types of derivatives have currently become a hot topic in synthetic organic and medicinal chemistry. Among the synthetic protocols towards fluorine-containing derivatives, either through nucleophilic or electrophilic late-stage fluorination or through the application of sophisticated fluorine-containing key elements, the access of various highly functionalized derivatives in view of selectivity, robustness, cost, efficiency, or applicability is still a significant challenge. I believe that synthetic fluorination methods as well as fluorine-containing structural elements presented in the submitted papers will be of interest not only to groups already involved in organofluorine chemistry but to the large community of synthetic and medicinal chemists, and that they will significantly affect future drug design. I am convinced that works published in this Special Issue of Molecules will further contribute to the advancement of organofluorine chemistry. Therefore, I strongly encurage fluorine chemists and the wider community of synthetic chemists to submit manuscripts for this Special Issue on Organofluorine Chemistry in the journal Molecules.
Prof. Dr. Loránd Kiss
Manuscript Submission Information
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- Selective fluorinations
- Fluorinated building blocks
- Pharmaceutical fluorine chemistry
- Late-stage fluorination
- Fluorinating agents
- Asymmetric synthesis