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Special Issue "Organofluorine Chemistry"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Loránd Kiss

Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eötvös u. 6, Hungary
Website | E-Mail
Interests: syntheses of three-dimensional, functionalized small-molecular entities with multiple chiral centers; transformations of beta-amino acid derivatives; synthesis of highly functionalized organofluorine building blocks

Special Issue Information

Dear Colleagues,

Organofluorine chemistry,which represents an expanding field of research in drug design, has generated increasing interest in pharmaceutical research over the past decade. Although fluorinated organic molecules are virtually nonexistent in nature, the number of novel fluorine-containing substances as well as fluorinated drugs is ever increasing. It is expected that fluorinated small-molecular entities (azaheterocycles, functionalized alicycles, amino acids, nucleosides, etc.), as potential bioactive scaffolds or building blocks, will be of high importance in drug research over the coming years. Accordingly, their syntheses and the development of versatile synthetic methods for these types of derivatives have currently become a hot topic in synthetic organic and medicinal chemistry. Among the synthetic protocols towards fluorine-containing derivatives, either through nucleophilic or electrophilic late-stage fluorination or through the application of sophisticated fluorine-containing key elements, the access of various highly functionalized derivatives in view of selectivity, robustness, cost, efficiency, or applicability is still a significant challenge. I believe that synthetic fluorination methods as well as fluorine-containing structural elements presented in the submitted papers will be of interest not only to groups already involved in organofluorine chemistry but to the large community of synthetic and medicinal chemists, and that they will significantly affect future drug design. I am convinced that works published in this Special Issue of Molecules will further contribute to the advancement of organofluorine chemistry. Therefore, I strongly encurage fluorine chemists and the wider community of synthetic chemists to submit manuscripts for this Special Issue on Organofluorine Chemistry in the journal Molecules.

Prof. Dr. Loránd Kiss
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Fluorine
  • Selective fluorinations
  • Fluorinated building blocks
  • Pharmaceutical fluorine chemistry
  • Late-stage fluorination
  • Fluorinating agents
  • Chirality
  • Asymmetric synthesis

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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