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Special Issue "Nanotechnology-Drug Delivery Systems"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editor

Prof. Zacharias Suntres
Website
Guest Editor
Northern Ontario School of Medicine, Thunder Bay, Canada
Interests: liposomes; ethosomes, exosomes, drug delivery systems; antioxidants; antibacterial; anti-inflammatory; chemotherapeutic agents; natural products

Special Issue Information

Dear Colleagues,

This Special Issue deals with all aspects of drug delivery systems based on nanotechnology platforms. It is recognized that the effectiveness of certain drugs is impeded by several challenges such as poor solubility, antigenicity, toxicity, inability to cross cell membrane barriers, poor bioavailability, and/or rapid clearance. One of the strategies available to improve the pharmacokinetic and pharmacodynamic properties of drugs is the utilization of drug delivery systems. In recent years there have been great advances in the development of drug delivery systems for carrying drugs to specific target sites within an organism including liposomes, ethosomes, exosomes, polymeric micelles, dendrimers, metallic nanoparticles, nanostructures, and other delivery systems based on several nanotechnology platforms. This Special Issue will cover topics related to the design and characterization of nanotechnology-based drug delivery systems and their clinical applications with emphasis on the current challenges and future direction.

Prof. Zacharias Suntres
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanotechnology
  • nanomedicine
  • nanomaterials
  • nanoparticles
  • nanocarriers
  • nanostructures
  • liposomes
  • ethososmes
  • exosomes
  • micelles
  • nanotubes

Published Papers (3 papers)

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Research

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Open AccessFeature PaperArticle
A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment
Molecules 2020, 25(5), 1088; https://doi.org/10.3390/molecules25051088 - 28 Feb 2020
Abstract
The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as [...] Read more.
The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as NT4, which is a promising cancer theranostic by virtue of its high cancer selectivity. We developed NT4 directly conjugated with one, two, or three units of paclitaxel and an NT4-based nanosystem, using NIR-emitting quantum dots, loaded with the NT4 tumor-targeting agent and conjugated with paclitaxel, to obtain a NT4-QD-PTX nanodevice designed to simultaneously detect and kill tumor cells. The selective binding and in vitro cytotoxicity of NT4-QD-PTX were higher than for unlabeled QD-PTX when tested on the human colon adenocarcinoma cell line HT-29. NT4-QD-PTX tumor-targeted nanoparticles can be considered promising for early tumor detection and for the development of effective treatments combining simultaneous therapy and diagnosis. Full article
(This article belongs to the Special Issue Nanotechnology-Drug Delivery Systems)
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Open AccessFeature PaperArticle
The High Permeability of Nanocarriers Crossing the Enterocyte Layer by Regulation of the Surface Zonal Pattern
Molecules 2020, 25(4), 919; https://doi.org/10.3390/molecules25040919 - 19 Feb 2020
Abstract
The intestinal epithelium is a major barrier that limits the absorption of oral drugs. The integrity of the epithelial tissue is a very important factor for preventing intestinal diseases. However, destabilization of the epithelium can promote the transportation of nanocarriers and increase the [...] Read more.
The intestinal epithelium is a major barrier that limits the absorption of oral drugs. The integrity of the epithelial tissue is a very important factor for preventing intestinal diseases. However, destabilization of the epithelium can promote the transportation of nanocarriers and increase the absorption of oral drugs. In our research, three different gold nanoparticles (GNPs) of the same size but with differing negative surface charge were designed and constructed as a model to determine the surface properties crucial for promoting absorptivity and bioavailability of the nanocarriers. The higher the ratio of surface carboxyl groups on GNPs, the higher capacity to induce transepithelial electrical resistance change and cell monolayer tight junction opening with higher permeability. The half carboxyl and half methyl surfaced GNPs displayed unique zonal surface patterns exhibited the greater ability to pass through intestinal epithelial cell layer but had a relatively small influence on tight junction distribution. Full article
(This article belongs to the Special Issue Nanotechnology-Drug Delivery Systems)
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Review

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Open AccessReview
Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review
Molecules 2020, 25(3), 689; https://doi.org/10.3390/molecules25030689 - 06 Feb 2020
Abstract
Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues [...] Read more.
Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such as cancers, a number of them have displayed issues associated with their solubility, bioavailability, and bio-degradability. In the present review, we focus on curcumin, an important and widely used polyphenol, with diverse pharmacological activities such as anti-inflammatory, anti-carcinogenic, anti-viral, etc. Notwithstanding, it also exhibits poor solubility and bioavailability that may compromise its clinical application to a great extent. Therefore, the manipulation and encapsulation of curcumin into a nanocarrier formulation can overcome these major drawbacks and potentially may lead to a far superior therapeutic efficacy. Among different types of nanocarriers, biological and biopolymer carriers have attracted a significant attention due to their pleiotropic features. Thus, in the present review, the potential protective and therapeutic applications of curcumin, as well as different types of bio-nanocarriers, which can be used to deliver curcumin effectively to the different target sites will be discussed. Full article
(This article belongs to the Special Issue Nanotechnology-Drug Delivery Systems)
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