Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate
Abstract
:1. Introduction
2. The Phosphoinositide Family
3. PI(4,5)P2 Structure
3.1. Headgroup Conformation
3.2. Membrane Conformation Dynamics
3.3. Headgroup Charge
3.4. Acyl-Chain Composition
4. Lateral Organization of PI(4,5)P2
4.1. Sequestration by Proteins
4.2. PI(4,5)P2 Interactions with Divalent Cations
4.3. Effect of Cholesterol on PI(4,5)P2 Properties and Distribution
4.4. Effect of the Cytoskeleton and Curvature on PI(4,5)P2 Lateral Organization
5. Concluding Remarks
Funding
Conflicts of Interest
References
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Borges-Araújo, L.; Fernandes, F. Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate. Molecules 2020, 25, 3885. https://doi.org/10.3390/molecules25173885
Borges-Araújo L, Fernandes F. Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate. Molecules. 2020; 25(17):3885. https://doi.org/10.3390/molecules25173885
Chicago/Turabian StyleBorges-Araújo, Luís, and Fabio Fernandes. 2020. "Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate" Molecules 25, no. 17: 3885. https://doi.org/10.3390/molecules25173885