Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate
1
iBB—Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal
2
Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal
*
Author to whom correspondence should be addressed.
Academic Editors: Luís M.S. Loura and Maria João Moreno
Molecules 2020, 25(17), 3885; https://doi.org/10.3390/molecules25173885
Received: 31 July 2020 / Revised: 22 August 2020 / Accepted: 23 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Membrane Structure and Function)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a minor but ubiquitous component of the inner leaflet of the plasma membrane of eukaryotic cells. However, due to its particular complex biophysical properties, it stands out from its neighboring lipids as one of the most important regulators of membrane-associated signaling events. Despite its very low steady-state concentration, PI(4,5)P2 is able to engage in a multitude of simultaneous cellular functions that are temporally and spatially regulated through the presence of localized transient pools of PI(4,5)P2 in the membrane. These pools are crucial for the recruitment, activation, and organization of signaling proteins and consequent regulation of downstream signaling. The present review showcases some of the most important PI(4,5)P2 molecular and biophysical properties as well as their impact on its membrane dynamics, lateral organization, and interactions with other biochemical partners.
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Keywords:
phosphoinositides; lipid domains; calcium-induced clustering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Borges-Araújo, L.; Fernandes, F. Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate. Molecules 2020, 25, 3885. https://doi.org/10.3390/molecules25173885
AMA Style
Borges-Araújo L, Fernandes F. Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate. Molecules. 2020; 25(17):3885. https://doi.org/10.3390/molecules25173885
Chicago/Turabian StyleBorges-Araújo, Luís; Fernandes, Fabio. 2020. "Structure and Lateral Organization of Phosphatidylinositol 4,5-bisphosphate" Molecules 25, no. 17: 3885. https://doi.org/10.3390/molecules25173885
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