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Molecules, Volume 24, Issue 2

2019 January-2 - 162 articles

Cover Story: Caribou and moose meats or antlers were observed to be rich in functional lipids, i.e., fatty acid esters of hydroxy fatty acids (FAHFAs), diglycerides (DGs), and monoacetyldiglycerides (MAcDGs). Emerging evidence suggests that these are new classes of functional lipids that have been demonstrated to have potential application in pharmaceuticals and functional food formulations in managing and preventing metabolic or inflammatory diseases including obesity, type 2 diabetes, sepsis, and rheumatoid arthritis. In this study, we demonstrated that moose and caribou meat or antlers are significant sources of polyunsaturaed FAHFAs and 1,3-DGs molecular species. Increasing access to and knowledge of the presence of these functional lipids in foods will enhance their intake in the diet with potential implications in improving personal and population health. View this paper.
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Articles (162)

  • Communication
  • Open Access
76 Citations
6,908 Views
8 Pages

Methyl Salicylate Enhances Flavonoid Biosynthesis in Tea Leaves by Stimulating the Phenylpropanoid Pathway

  • Xin Li,
  • Li-Ping Zhang,
  • Lan Zhang,
  • Peng Yan,
  • Golam Jalal Ahammed and
  • Wen-Yan Han

21 January 2019

The phytohormone salicylic acid (SA) is a secondary metabolite that regulates plant growth, development and responses to stress. However, the role of SA in the biosynthesis of flavonoids (a large class of secondary metabolites) in tea (Camellia sinen...

  • Article
  • Open Access
26 Citations
8,534 Views
15 Pages

21 January 2019

Developing phase change materials (PCMs) with suitable phase change temperatures and high latent heat is of great significance for accelerating the development of latent heat storage technology to be applied in solar water heating (SWH) systems. The...

  • Article
  • Open Access
38 Citations
6,648 Views
14 Pages

21 January 2019

In our studies on the catalytic activity of Group IVB transition metal Lewis acids, Hf(OTf)4 was identified as a highly potent catalyst for ”one-pot, three-component” Biginelli reaction. More importantly, it was found that solvent-free co...

  • Review
  • Open Access
98 Citations
8,722 Views
15 Pages

Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases

  • Mariane Lutz,
  • Eduardo Fuentes,
  • Felipe Ávila,
  • Marcelo Alarcón and
  • Iván Palomo

21 January 2019

The population is now living longer during the period classified as “elderly” (60 years and older), exhibiting multimorbidity associated to the lengthening of the average life span. The dietary intake of phenolic compounds (PC) may affect the physiol...

  • Article
  • Open Access
19 Citations
5,337 Views
11 Pages

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

  • Ching-Chiung Wang,
  • Hsyeh-Fang Chen,
  • Jin-Yi Wu and
  • Lih-Geeng Chen

21 January 2019

The fruit and hulls of the water caltrop (Trapa taiwanensis Nakai) are used as hepatoprotective herbal tea ingredients in Taiwan. The stability of hydrolysable tannins in herbal drinks has rarely been reported. In the present study, two hydrolysable...

  • Article
  • Open Access
50 Citations
7,075 Views
31 Pages

21 January 2019

Lung cancer constitutes 85% of non-small cell lung cancer diagnosed cases. MicroRNAs are novel biomarkers that are capable of modulating multiple oncogenic pathways. Epigallocatechin-3-gallate (EGCG) is a potent chemopreventive and chemotherapeutic a...

  • Article
  • Open Access
94 Citations
7,777 Views
14 Pages

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

  • Hui Shi,
  • Xiao-Long Wang,
  • Hong-Feng Quan,
  • Lin Yan,
  • Xiu-Ying Pei,
  • Rui Wang and
  • Xiao-Dong Peng

21 January 2019

Microglia mediate multiple facets of neuroinflammation. They can be phenotypically divided into a classical phenotype (pro-inflammatory, M1) or an alternative phenotype (anti-inflammatory, M2) with different physiological characteristics and biologic...

  • Article
  • Open Access
18 Citations
5,220 Views
15 Pages

21 January 2019

Several economies around the world are using second-generation (2G) ethanol produced from agricultural residues, like sugarcane straw and bagasse, as a sustainable solution to replace petroleum products. Since first-generation (1G) ethanol uses the s...

  • Review
  • Open Access
516 Citations
20,902 Views
25 Pages

21 January 2019

Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases. In recent years, a considerable number of studies have been published concerning th...

  • Article
  • Open Access
6 Citations
3,849 Views
14 Pages

21 January 2019

Chronic skin inflammatory diseases, such as atopic dermatitis, are associated with a dysfunctional skin barrier due to an increase in various inflammatory stimuli, for instance inflammatory cytokines and chemokines. In particular, CCL17 and CCL22 exp...

  • Article
  • Open Access
17 Citations
4,775 Views
26 Pages

Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections

  • Francesca Bonvicini,
  • Giovanna A. Gentilomi,
  • Francesca Bressan,
  • Silvia Gobbi,
  • Angela Rampa,
  • Alessandra Bisi and
  • Federica Belluti

21 January 2019

The occurrence of invasive fungal infections represents a substantial threat to human health that is particularly serious in immunocompromised patients. The limited number of antifungal agents, devoid of unwanted toxic effects, has resulted in an inc...

  • Article
  • Open Access
41 Citations
5,396 Views
12 Pages

21 January 2019

Endometritis, inflammation of the endometrium, is a common reproductive obstacle disease that can lead to infertility in female animals. Astragaloside IV (AS IV), one of the major and active components of the Astragalus membranaceus (Fisch.) Bunge, i...

  • Article
  • Open Access
16 Citations
6,314 Views
16 Pages

21 January 2019

Decoction is one of the oldest forms of traditional Chinese medicine and it is widely used in clinical practice. However, the quality evaluation and control of traditional decoction is a challenge due to the characteristics of complicated constituent...

  • Article
  • Open Access
12 Citations
5,270 Views
14 Pages

21 January 2019

A turn-on florescent probe (probe-KCP) was developed for highly selective detection of thiophenols based on a donor-excited photo-induced electron transfer mechanism. Herein, the synthesis of the probe, a chalcone derivative, through a simple straigh...

  • Article
  • Open Access
36 Citations
5,458 Views
19 Pages

Dual Geometry Schemes in Tetrel Bonds: Complexes between TF4 (T = Si, Ge, Sn) and Pyridine Derivatives

  • Wiktor Zierkiewicz,
  • Mariusz Michalczyk,
  • Rafał Wysokiński and
  • Steve Scheiner

21 January 2019

When an N-base approaches the tetrel atom of TF4 (T = Si, Ge, Sn) the latter molecule deforms from a tetrahedral structure in the monomer to a trigonal bipyramid. The base can situate itself at either an axial or equatorial position, leading to two d...

  • Article
  • Open Access
57 Citations
11,400 Views
11 Pages

Development and Validation of a LC–MS/MS-Based Assay for Quantification of Free and Total Omega 3 and 6 Fatty Acids from Human Plasma

  • Vlad Serafim,
  • Diana-Andreea Tiugan,
  • Nicoleta Andreescu,
  • Alexandra Mihailescu,
  • Corina Paul,
  • Iulian Velea,
  • Maria Puiu and
  • Mihai Dinu Niculescu

20 January 2019

Few high-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods have been developed for the full quantitation of fatty acids from human plasma without derivatization. Therefore, we propose a method that requires fewer sam...

  • Article
  • Open Access
31 Citations
5,693 Views
12 Pages

20 January 2019

Cr2O3 nanoparticles were prepared by solution combustion synthesis (SCS) with chromium nitrate as the precursor and glycine as the fuel. Commercial Cr2O3 and Cr2O3 prepared by a precipitation method were also included for comparison. The morphology,...

  • Article
  • Open Access
8 Citations
5,421 Views
18 Pages

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

  • Andrei I. Khlebnikov,
  • Igor A. Schepetkin,
  • Anarkul S. Kishkentaeva,
  • Zhanar R. Shaimerdenova,
  • Gayane A. Atazhanova,
  • Sergazy M. Adekenov,
  • Liliya N. Kirpotina and
  • Mark T. Quinn

19 January 2019

A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine thei...

  • Feature Paper
  • Review
  • Open Access
217 Citations
16,062 Views
27 Pages

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

  • Diego Tesauro,
  • Antonella Accardo,
  • Carlo Diaferia,
  • Vittoria Milano,
  • Jean Guillon,
  • Luisa Ronga and
  • Filomena Rossi

19 January 2019

Peptides of natural and synthetic sources are compounds operating in a wide range of biological interactions. They play a key role in biotechnological applications as both therapeutic and diagnostic tools. They are easily synthesized thanks to solid-...

  • Article
  • Open Access
4 Citations
5,172 Views
17 Pages

Synthesis and Gelling Abilities of Polyfunctional Cyclohexane-1,2-dicarboxylic Acid Bisamides: Influence of the Hydroxyl Groups

  • Bernat Pi-Boleda,
  • María Campos,
  • Marta Sans,
  • Antonio Basavilbaso,
  • Ona Illa,
  • Vicenç Branchadell,
  • Juan Carlos Estévez and
  • Rosa M. Ortuño

19 January 2019

New enantiomerically pure C16-alkyl diamides derived from trihydroxy cyclohexane-1,2-dicarboxylic acid have been synthesized from (−)-shikimic acid. The hydroxyl groups in these compounds are free or, alternatively, they present full or partial...

  • Article
  • Open Access
22 Citations
5,475 Views
9 Pages

Deep-Blue and Hybrid-White Organic Light Emitting Diodes Based on a Twisting Carbazole-Benzofuro[2,3-b]Pyrazine Fluorescent Emitter

  • Chen-Chao Huang,
  • Miao-Miao Xue,
  • Fu-Peng Wu,
  • Yi Yuan,
  • Liang-Sheng Liao and
  • Man-Keung Fung

19 January 2019

A novel deep-blue fluorescent emitter was designed and synthesized. The external quantum efficiency (ηEQE) of the blue-emitting, doped, organic light-emitting diode (OLED) was as high as 4.34%. The device also exhibited an excellent color purity...

  • Article
  • Open Access
5 Citations
5,499 Views
18 Pages

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

  • Cécile Baudoin-Dehoux,
  • Tessa Castellan,
  • Frédéric Rodriguez,
  • Arnaud Rives,
  • Fabien Stauffert,
  • Virginie Garcia,
  • Thierry Levade,
  • Philippe Compain and
  • Yves Génisson

19 January 2019

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how a...

  • Review
  • Open Access
91 Citations
10,938 Views
35 Pages

Recent Developments in the Functionalization of Betulinic Acid and Its Natural Analogues: A Route to New Bioactive Compounds

  • Joana L. C. Sousa,
  • Carmen S. R. Freire,
  • Armando J. D. Silvestre and
  • Artur M. S. Silva

19 January 2019

Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in many plants and display important biological activities. This review focus...

  • Article
  • Open Access
13 Citations
4,141 Views
15 Pages

19 January 2019

In this study, we investigated changes in the structural and immunological features of polysaccharides (S1-PLE0, S2-PLE0, and S3-PLE0) extracted from persimmon leaves at three different growth stages. Physicochemical analyses revealed that their chem...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,254 Views
10 Pages

Rare Earth Hydroxide as a Precursor for Controlled Fabrication of Uniform β-NaYF4 Nanoparticles: A Novel, Low Cost, and Facile Method

  • Lili Xu,
  • Man Wang,
  • Qing Chen,
  • Jiajia Yang,
  • Wubin Zheng,
  • Guanglei Lv,
  • Zewei Quan and
  • Chunxia Li

19 January 2019

In recent years, rare earth doped upconversion nanocrystals have been widely used in different fields owing to their unique merits. Although rare earth chlorides and trifluoroacetates are commonly used precursors for the synthesis of nanocrystals, th...

  • Article
  • Open Access
11 Citations
5,344 Views
21 Pages

Tripleurin XIIc: Peptide Folding Dynamics in Aqueous and Hydrophobic Environment Mimic Using Accelerated Molecular Dynamics

  • Chetna Tyagi,
  • Tamás Marik,
  • András Szekeres,
  • Csaba Vágvölgyi,
  • László Kredics and
  • Ferenc Ötvös

19 January 2019

Peptaibols are a special class of fungal peptides with an acetylated N-terminus and a C-terminal 1,2-amino alcohol along with non-standard amino acid residues. New peptaibols named tripleurins were recently identified from a strain of the filamentous...

  • Review
  • Open Access
117 Citations
17,552 Views
40 Pages

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

  • Wenxiang Fan,
  • Linhong Fan,
  • Chengyi Peng,
  • Qing Zhang,
  • Li Wang,
  • Lin Li,
  • Jiaolong Wang,
  • Dayong Zhang,
  • Wei Peng and
  • Chunjie Wu

19 January 2019

Xanthium strumarium L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research,...

  • Review
  • Open Access
33 Citations
7,362 Views
17 Pages

Perspectives on the Use of Liquid Extraction for Radioisotope Purification

  • Petra Martini,
  • Andrea Adamo,
  • Neilesh Syna,
  • Alessandra Boschi,
  • Licia Uccelli,
  • Nopphon Weeranoppanant,
  • Jack Markham and
  • Giancarlo Pascali

18 January 2019

The reliable and efficient production of radioisotopes for diagnosis and therapy is becoming an increasingly important capability, due to their demonstrated utility in Nuclear Medicine applications. Starting from the first processes involving the sep...

  • Article
  • Open Access
15 Citations
4,827 Views
15 Pages

Structural and Thermal Analysis of Softwood Lignins from a Pressurized Hot Water Extraction Biorefinery Process and Modified Derivatives

  • Lucas Lagerquist,
  • Andrey Pranovich,
  • Ivan Sumerskii,
  • Sebastian von Schoultz,
  • Lari Vähäsalo,
  • Stefan Willför and
  • Patrik Eklund

18 January 2019

In this work we have analyzed the pine and spruce softwood lignin fraction recovered from a novel pressurized hot water extraction pilot process. The lignin structure was characterized using multiple NMR techniques and the thermal properties were ana...

  • Article
  • Open Access
11 Citations
4,259 Views
15 Pages

Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects

  • Chen Liu,
  • Pengxiang Wu,
  • He Zhu,
  • Paolo Grieco,
  • Ruihe Yu,
  • Xinmei Gao,
  • Guiyue Wu,
  • Dong Wang,
  • Hanmei Xu and
  • Weiyan Qi

18 January 2019

A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine re...

  • Communication
  • Open Access
71 Citations
6,150 Views
15 Pages

Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs—A Promising Approach to Fight Cancer Drug Resistance

  • Gabriella Spengler,
  • Márió Gajdács,
  • Małgorzata Anna Marć,
  • Enrique Domínguez-Álvarez and
  • Carmen Sanmartín

18 January 2019

Malignant diseases present a serious public health burden and their treatment with traditional chemotherapy cannot be considered an all-round solution, due to toxic side effects. Selenium compounds (Se-compounds) have received substantial attention i...

  • Article
  • Open Access
31 Citations
5,186 Views
14 Pages

18 January 2019

Fuzheng huayu formula (FZHY), an antifibrotic traditional Chinese medicine, is frequently used for the treatment of liver fibrosis. In this study, network analysis, transcriptomic analysis, assays of cell apoptosis, viability and protein expression w...

  • Article
  • Open Access
30 Citations
6,314 Views
13 Pages

18 January 2019

Arsenic contamination of drinking water is a global concern. Standard laboratory methods that are commonly used for arsenic detection in water, such as atomic absorption spectroscopy and mass spectroscopy, are not suitable for mass monitoring purpose...

  • Article
  • Open Access
80 Citations
8,771 Views
16 Pages

UV Photoprotection, Cytotoxicity and Immunology Capacity of Red Algae Extracts

  • Félix Álvarez-Gómez,
  • Nathalie Korbee,
  • Virginia Casas-Arrojo,
  • Roberto T. Abdala-Díaz and
  • Félix L. Figueroa

18 January 2019

This study was designed to evaluate the potential use of algal extracts in cosmeceuticals, including factors related to biosecurity. The aqueous crude extracts of Hydropuntia cornea and Gracilariopsis longissima showed a good photoprotective capacity...

  • Communication
  • Open Access
23 Citations
5,501 Views
8 Pages

18 January 2019

The essential oil from Phytolacca dodecandra, a traditional herb of Ethiopia, has been studied, including the chemical composition and antimicrobial activity. The difference between four P. dodecandra samples (P-1–P-4), which differed in gender...

  • Feature Paper
  • Article
  • Open Access
36 Citations
6,064 Views
13 Pages

18 January 2019

The pathogenesis of prediabetes is associated with risk factors such as chronic consumption of an unhealthy diet. Recent studies have reported that diet-induced pre-diabetes is also associated with risk factors of cardiovascular complications, hence...

  • Article
  • Open Access
25 Citations
4,767 Views
15 Pages

18 January 2019

Hwangryunhaedok-tang (HRT) is a traditional oriental herbal formula used in Asian countries for treating inflammatory diseases and controlling fever. Our present study aimed to determine whether HRT has therapeutic effects for patients with vascular...

  • Article
  • Open Access
59 Citations
8,366 Views
13 Pages

Visible-Light Driven TiO2 Photocatalyst Coated with Graphene Quantum Dots of Tunable Nitrogen Doping

  • Xiong Sun,
  • Hui-Jun Li,
  • Nanquan Ou,
  • Bowen Lyu,
  • Bojie Gui,
  • Shiwei Tian,
  • Dongjin Qian,
  • Xianying Wang and
  • Junhe Yang

18 January 2019

Nitrogen doped graphene quantum dots (NGQDs) were successfully prepared via a hydrothermal method using citric acid and urea as the carbon and nitrogen precursors, respectively. Due to different post-treatment processes, the obtained NGQDs with diffe...

  • Article
  • Open Access
40 Citations
7,494 Views
14 Pages

Multi-Layer Application of Self-Etch and Universal Adhesives and the Effect on Dentin Bond Strength

  • Anna Zecin-Deren,
  • Jerzy Sokolowski,
  • Agata Szczesio-Wlodarczyk,
  • Ireneusz Piwonski,
  • Monika Lukomska-Szymanska and
  • Barbara Lapinska

18 January 2019

Contemporary self-etch and multi-mode adhesives were introduced to ensure a fast and reliable bonding procedure. Yet, in terms of bond strength and stability they failed to perform as well as two-bottle, etch-and-rinse adhesives, which remain the gol...

  • Article
  • Open Access
138 Citations
9,202 Views
14 Pages

18 January 2019

Polymeric nanoparticles based on fucoidan and chitosan were developed to deliver quercetin as a novel functional food. Through the polyelectrolyte self-assembly method, fucoidan/chitosan (F/C) nanoparticles were obtained with three different weight r...

  • Review
  • Open Access
76 Citations
19,386 Views
15 Pages

Peptides for Skin Protection and Healing in Amphibians

  • Ilaria Demori,
  • Zeinab El Rashed,
  • Viola Corradino,
  • Annamaria Catalano,
  • Leila Rovegno,
  • Linda Queirolo,
  • Sebastiano Salvidio,
  • Emanuele Biggi,
  • Matteo Zanotti-Russo and
  • Elena Grasselli
  • + 2 authors

18 January 2019

Amphibian skin is not to be considered a mere tegument; it has a multitude of functions related to respiration, osmoregulation, and thermoregulation, thus allowing the individuals to survive and thrive in the terrestrial environment. Moreover, amphib...

  • Article
  • Open Access
1 Citations
4,253 Views
13 Pages

Revealing the Presence of a Symbolic Sequence Representing Multiple Nucleotides Based on K-Means Clustering of Oligonucleotides

  • Byoungsang Lee,
  • So Yeon Ahn,
  • Charles Park,
  • James J. Moon,
  • Jung Heon Lee,
  • Dan Luo,
  • Soong Ho Um and
  • Seung Won Shin

18 January 2019

In biological systems, a few sequence differences diversify the hybridization profile of nucleotides and enable the quantitative control of cellular metabolism in a cooperative manner. In this respect, the information required for a better understand...

  • Article
  • Open Access
3 Citations
5,018 Views
13 Pages

18 January 2019

The biology of the group of plant hormones termed cytokinins is reviewed to reveal areas where further studies of cytokinin-binding proteins could be significant. Such areas include: inhibition of human tumour cell growth by cytokinin ribosides, the...

  • Article
  • Open Access
103 Citations
5,807 Views
11 Pages

Partial Characterization, the Immune Modulation and Anticancer Activities of Sulfated Polysaccharides from Filamentous Microalgae Tribonema sp.

  • Xiaolin Chen,
  • Lin Song,
  • Hui Wang,
  • Song Liu,
  • Huahua Yu,
  • Xueqin Wang,
  • Rongfeng Li,
  • Tianzhong Liu and
  • Pengcheng Li

17 January 2019

Recently, Tribonema sp., a kind of filamentous microalgae, has been studied for biofuel production due to its accumulation of triacylglycerols. However, the polysaccharides of Tribonema sp. and their biological activities have rarely been reported. I...

  • Article
  • Open Access
33 Citations
7,729 Views
8 Pages

17 January 2019

The safety, efficacy and stability of natural antioxidants have been the focus of research in the food industry, with the aim of rapidly analyzing and controlling the quality of rosemary and its extracts, a novel analytical method involving high-perf...

  • Article
  • Open Access
8 Citations
6,611 Views
20 Pages

Polymerizable Ionic Liquids for Solid-State Polymer Electrolytes

  • Robert Löwe,
  • Thomas Hanemann and
  • Andreas Hofmann

17 January 2019

Eight new polymerizable ammonium-TFSI ionic liquids were synthesized and characterized with respect to an application in energy storage devices. The ionic liquids feature methacrylate or acrylate termination as polymerizable groups. The preparation w...

  • Communication
  • Open Access
10 Citations
5,692 Views
13 Pages

The Triple-Decker Complex [Cp*Fe(µ,η55-P5)Mo(CO)3] as a Building Block in Coordination Chemistry

  • Mehdi Elsayed Moussa,
  • Stefan Welsch,
  • Luis Dütsch,
  • Martin Piesch,
  • Stephan Reichl,
  • Michael Seidl and
  • Manfred Scheer

17 January 2019

Although the triple-decker complex [Cp*Fe(µ,η55-P5)Mo(CO)3] (2) was first reported 26 years ago, its reactivity has not yet been explored. Herein, we report a new high-yielding synthesis of 2 and the isolation of its new polymorph (2&...

  • Article
  • Open Access
10 Citations
6,897 Views
18 Pages

Synthesis, In Silico, and In Vitro Evaluation of Long Chain Alkyl Amides from 2-Amino-4-Quinolone Derivatives as Biofilm Inhibitors

  • Mariana Paola Espinosa-Valdés,
  • Sara Borbolla-Alvarez,
  • Ana Elena Delgado-Espinosa,
  • Juan Francisco Sánchez-Tejeda,
  • Anabelle Cerón-Nava,
  • Osvaldo Javier Quintana-Romero,
  • Armando Ariza-Castolo,
  • Diego Fernando García-Del Río and
  • Marco A. Loza-Mejía

17 January 2019

Infection from multidrug resistant bacteria has become a growing health concern worldwide, increasing the need for developing new antibacterial agents. Among the strategies that have been studied, biofilm inhibitors have acquired relevance as a poten...

  • Article
  • Open Access
95 Citations
8,083 Views
13 Pages

Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo

  • Li Liu,
  • Yu Dong,
  • Xin Shan,
  • Lin Li,
  • Baomei Xia and
  • Hanqing Wang

17 January 2019

Baicalin (BA), a major polyphenol compound isolated from the extracts of Scutellaria radix, has been previously reported to ameliorate depressive-like behaviors in mice with chronic unpredictable mild stress (CUMS). However, its underlying antidepres...

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Molecules - ISSN 1420-3049