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Molecules, Volume 24, Issue 2

January-2 2019 - 162 articles

Cover Story: Caribou and moose meats or antlers were observed to be rich in functional lipids, i.e., fatty acid esters of hydroxy fatty acids (FAHFAs), diglycerides (DGs), and monoacetyldiglycerides (MAcDGs). Emerging evidence suggests that these are new classes of functional lipids that have been demonstrated to have potential application in pharmaceuticals and functional food formulations in managing and preventing metabolic or inflammatory diseases including obesity, type 2 diabetes, sepsis, and rheumatoid arthritis. In this study, we demonstrated that moose and caribou meat or antlers are significant sources of polyunsaturaed FAHFAs and 1,3-DGs molecular species. Increasing access to and knowledge of the presence of these functional lipids in foods will enhance their intake in the diet with potential implications in improving personal and population health. View this paper.
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Articles (162)

  • Article
  • Open Access
92 Citations
7,430 Views
14 Pages

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

  • Hui Shi,
  • Xiao-Long Wang,
  • Hong-Feng Quan,
  • Lin Yan,
  • Xiu-Ying Pei,
  • Rui Wang and
  • Xiao-Dong Peng

21 January 2019

Microglia mediate multiple facets of neuroinflammation. They can be phenotypically divided into a classical phenotype (pro-inflammatory, M1) or an alternative phenotype (anti-inflammatory, M2) with different physiological characteristics and biologic...

  • Article
  • Open Access
17 Citations
5,087 Views
15 Pages

21 January 2019

Several economies around the world are using second-generation (2G) ethanol produced from agricultural residues, like sugarcane straw and bagasse, as a sustainable solution to replace petroleum products. Since first-generation (1G) ethanol uses the s...

  • Review
  • Open Access
494 Citations
20,315 Views
25 Pages

21 January 2019

Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases. In recent years, a considerable number of studies have been published concerning th...

  • Article
  • Open Access
6 Citations
3,767 Views
14 Pages

21 January 2019

Chronic skin inflammatory diseases, such as atopic dermatitis, are associated with a dysfunctional skin barrier due to an increase in various inflammatory stimuli, for instance inflammatory cytokines and chemokines. In particular, CCL17 and CCL22 exp...

  • Article
  • Open Access
17 Citations
4,651 Views
26 Pages

Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections

  • Francesca Bonvicini,
  • Giovanna A. Gentilomi,
  • Francesca Bressan,
  • Silvia Gobbi,
  • Angela Rampa,
  • Alessandra Bisi and
  • Federica Belluti

21 January 2019

The occurrence of invasive fungal infections represents a substantial threat to human health that is particularly serious in immunocompromised patients. The limited number of antifungal agents, devoid of unwanted toxic effects, has resulted in an inc...

  • Article
  • Open Access
54 Citations
10,898 Views
11 Pages

Development and Validation of a LC–MS/MS-Based Assay for Quantification of Free and Total Omega 3 and 6 Fatty Acids from Human Plasma

  • Vlad Serafim,
  • Diana-Andreea Tiugan,
  • Nicoleta Andreescu,
  • Alexandra Mihailescu,
  • Corina Paul,
  • Iulian Velea,
  • Maria Puiu and
  • Mihai Dinu Niculescu

20 January 2019

Few high-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods have been developed for the full quantitation of fatty acids from human plasma without derivatization. Therefore, we propose a method that requires fewer sam...

  • Article
  • Open Access
31 Citations
5,524 Views
12 Pages

20 January 2019

Cr2O3 nanoparticles were prepared by solution combustion synthesis (SCS) with chromium nitrate as the precursor and glycine as the fuel. Commercial Cr2O3 and Cr2O3 prepared by a precipitation method were also included for comparison. The morphology,...

  • Article
  • Open Access
8 Citations
5,317 Views
18 Pages

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

  • Andrei I. Khlebnikov,
  • Igor A. Schepetkin,
  • Anarkul S. Kishkentaeva,
  • Zhanar R. Shaimerdenova,
  • Gayane A. Atazhanova,
  • Sergazy M. Adekenov,
  • Liliya N. Kirpotina and
  • Mark T. Quinn

19 January 2019

A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine thei...

  • Feature Paper
  • Review
  • Open Access
214 Citations
15,685 Views
27 Pages

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

  • Diego Tesauro,
  • Antonella Accardo,
  • Carlo Diaferia,
  • Vittoria Milano,
  • Jean Guillon,
  • Luisa Ronga and
  • Filomena Rossi

19 January 2019

Peptides of natural and synthetic sources are compounds operating in a wide range of biological interactions. They play a key role in biotechnological applications as both therapeutic and diagnostic tools. They are easily synthesized thanks to solid-...

  • Article
  • Open Access
4 Citations
5,028 Views
17 Pages

Synthesis and Gelling Abilities of Polyfunctional Cyclohexane-1,2-dicarboxylic Acid Bisamides: Influence of the Hydroxyl Groups

  • Bernat Pi-Boleda,
  • María Campos,
  • Marta Sans,
  • Antonio Basavilbaso,
  • Ona Illa,
  • Vicenç Branchadell,
  • Juan Carlos Estévez and
  • Rosa M. Ortuño

19 January 2019

New enantiomerically pure C16-alkyl diamides derived from trihydroxy cyclohexane-1,2-dicarboxylic acid have been synthesized from (−)-shikimic acid. The hydroxyl groups in these compounds are free or, alternatively, they present full or partial...

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Molecules - ISSN 1420-3049