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Molecules 2019, 24(2), 347; https://doi.org/10.3390/molecules24020347

Peptides for Skin Protection and Healing in Amphibians

1
Dipartimento Scienze della Terra dell’Ambiente e della Vita—DISTAV, Università degli Studi di Genova—16132 Genova, Italy
2
iDelivery iSrl, Via Eremo al Santuario n.75/A, 89124 Reggio Calabria, Italy
3
International League of Conservation Photographers, Arlington, VA 22203, USA
4
Angel Consulting via San Senatore 14, 20122 Milano, Italy
5
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
*
Author to whom correspondence should be addressed.
Received: 19 December 2018 / Revised: 16 January 2019 / Accepted: 17 January 2019 / Published: 18 January 2019
(This article belongs to the Section Bioorganic Chemistry)
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PDF [1572 KB, uploaded 22 January 2019]
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Abstract

Amphibian skin is not to be considered a mere tegument; it has a multitude of functions related to respiration, osmoregulation, and thermoregulation, thus allowing the individuals to survive and thrive in the terrestrial environment. Moreover, amphibian skin secretions are enriched with several peptides, which defend the skin from environmental and pathogenic insults and exert many other biological effects. In this work, the beneficial effects of amphibian skin peptides are reviewed, in particular their role in speeding up wound healing and in protection from oxidative stress and UV irradiation. A better understanding of why some species seem to resist several environmental insults can help to limit the ongoing amphibian decline through the development of appropriate strategies, particularly against pathologies such as viral and fungal infections. View Full-Text
Keywords: keratinized tegument; amphibian skin peptides; wound healing; UV-irradiation protection; skin defenses; eco-physiology; animal physiology; Batracochytrium dendrobatidis keratinized tegument; amphibian skin peptides; wound healing; UV-irradiation protection; skin defenses; eco-physiology; animal physiology; Batracochytrium dendrobatidis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Demori, I.; El Rashed, Z.; Corradino, V.; Catalano, A.; Rovegno, L.; Queirolo, L.; Salvidio, S.; Biggi, E.; Zanotti-Russo, M.; Canesi, L.; Catenazzi, A.; Grasselli, E. Peptides for Skin Protection and Healing in Amphibians. Molecules 2019, 24, 347.

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