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Molecules, Volume 23, Issue 2

February 2018 - 290 articles

Cover Story: Biocatalysts able to convert nitroaromatics to aromatic amines are in high demand, yet they are not commonly found in nature and only succeed for a small number of known substrates. The question therefore is “Why”? We show that substrates with large pi systems-bearing electron withdrawing groups, are more likely to form amines. Crucially, nitroreductases accommodate many such substrates. We attribute this to their intertwined architecture that supports very diverse active site shapes and sizes. This segregation of core structure vs. catalytic site, eminently suits the engineering of nitroreductases. View this paper
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Articles (290)

  • Article
  • Open Access
8 Citations
5,088 Views
9 Pages

Bioactive Phenolic and Isocoumarin Glycosides from the Stems of Homalium paniculiflorum

  • Shou-Yuan Wu,
  • Yan-Hui Fu,
  • Qi Zhou,
  • Meng Bai,
  • Guang-Ying Chen,
  • Si-Yu Zhao,
  • Chang-Ri Han and
  • Xiao-Ping Song

22 February 2018

Two new phenolic glycosides (1 and 2) and two new isocoumarin glycosides (3 and 4), along with 14 known compounds (5–18), were isolated from the stems of Homalium paniculiflorum. Their structures were established on the basis of extensive spectroscop...

  • Article
  • Open Access
48 Citations
5,855 Views
16 Pages

Assessment of Chitosan-Based Hydrogel and Photodynamic Inactivation against Propionibacterium acnes

  • Maria Lucia Frade,
  • Sarah Raquel De Annunzio,
  • Giovana Maria Fioramonti Calixto,
  • Francesca Damiani Victorelli,
  • Marlus Chorilli and
  • Carla Raquel Fontana

22 February 2018

Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the ef...

  • Review
  • Open Access
120 Citations
8,634 Views
16 Pages

22 February 2018

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hep...

  • Article
  • Open Access
21 Citations
4,744 Views
9 Pages

22 February 2018

A selective and ratiometric turn-on fluorescent probe was designed and synthesized by using a novel dicyanoisophorone-based derivative and acrylate moiety. The probe displayed high stability and good selectivity to cysteine (Cys) over homocysteine (H...

  • Article
  • Open Access
16 Citations
4,905 Views
13 Pages

Study of Hexane Adsorption on Activated Carbons with Differences in Their Surface Chemistry

  • Diana Hernández-Monje,
  • Liliana Giraldo and
  • Juan Carlos Moreno-Piraján

22 February 2018

The study of aliphatic compounds adsorption on activated carbon can be carried out from the energetic change involved in the interaction; the energy values can be determined from isotherms or by the immersion enthalpy. Vapor phase adsorption isotherm...

  • Article
  • Open Access
43 Citations
7,356 Views
12 Pages

22 February 2018

Phycocyanin (Pc) is one of the active pigment constituents of Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, the protective effects of Pc against ultraviolet-B (UVB)-induced primary skin c...

  • Article
  • Open Access
5 Citations
3,486 Views
15 Pages

Structure-Antiplatelet Activity Relationships of Novel Ruthenium (II) Complexes: Investigation of Its Molecular Targets

  • Chih-Hsuan Hsia,
  • Thanasekaran Jayakumar,
  • Joen-Rong Sheu,
  • Shin-Yi Tsao,
  • Marappan Velusamy,
  • Chih-Wei Hsia,
  • Duen-Suey Chou,
  • Chao-Chien Chang,
  • Chi-Li Chung and
  • Themmila Khamrang
  • + 1 author

22 February 2018

The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven to be a positive approach to the prevention of thrombosis. Ruthenium complexes are fascinating for the development of new drugs, as they possess...

  • Feature Paper
  • Article
  • Open Access
19 Citations
7,866 Views
25 Pages

Recognition of AMP, ADP and ATP through Cooperative Binding by Cu(II) and Zn(II) Complexes Containing Urea and/or Phenylboronic—Acid Moieties

  • Israel Carreira-Barral,
  • Isabel Fernández-Pérez,
  • Marta Mato-Iglesias,
  • Andrés De Blas,
  • Carlos Platas-Iglesias and
  • David Esteban-Gómez

22 February 2018

We report a series of Cu(II) and Zn(II) complexes with different ligands containing a dipicolyl unit functionalized with urea groups that may contain or not a phenylboronic acid function. These complexes were designed for the recognition of phosphory...

  • Article
  • Open Access
55 Citations
6,756 Views
12 Pages

21 February 2018

Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation an...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,390 Views
13 Pages

A Hexahomotrioxacalix[3]arene-Based Ditopic Receptor for Alkylammonium Ions Controlled by Ag+ Ions

  • Xue-Kai Jiang,
  • Yusuke Ikejiri,
  • Chong Wu,
  • Shofiur Rahman,
  • Paris E. Georghiou,
  • Xi Zeng,
  • Mark R. J. Elsegood,
  • Carl Redshaw,
  • Simon J. Teat and
  • Takehiko Yamato

21 February 2018

A receptor cone-1 based on a hexahomotrioxacalix[3]arene bearing three pyridyl groups was successfully synthesized, which has a C3-symmetric conformation and is capable of binding alkylammonium and metal ions simultaneously in a cooperative fashion....

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Molecules - ISSN 1420-3049