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Molecules, Volume 23, Issue 3

March 2018 - 199 articles

Cover Story: The Cu2+ complex of dipicolylamine (DPA)-modified β-cyclodextrin (CyD) selectively recognized ATP over other phosphoric acid derivatives in water. The NMR analyses suggested that the specific ATP selectivity was based on multi-point recognition including the host–guest interaction between the adenine moiety of ATP and the CyD cavity, and coordination bond of phosphoric moieties to the Cu2+–DPA complex site. View this paper
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Articles (199)

  • Article
  • Open Access
21 Citations
7,809 Views
12 Pages

Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms

  • Thaís B. Alves,
  • Tatiana M. Souza-Moreira,
  • Sandro R. Valentini,
  • Cleslei F. Zanelli and
  • Maysa Furlan

Triterpenes are interesting compounds because they play an important role in cell homeostasis and a wide variety exhibiting defense functions is produced by plant secondary metabolism. Those same plant secondary metabolites also exhibit biological pr...

  • Article
  • Open Access
18 Citations
6,020 Views
9 Pages

A copper complex with square planar geometry, [(L)CuBr2] (1), (L = N′-(furan-2-ylmethylene)adamantne-1-carbohydrazide) has been synthesized and characterized by Fourier transfer infrared (FTIR) spectroscopy, elemental analysis, mass spectrometry, and...

  • Article
  • Open Access
11 Citations
6,209 Views
13 Pages

Bridging from Brain to Tumor Imaging: (S)-(−)- and (R)-(+)-[18F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice

  • Mathias Kranz,
  • Ralf Bergmann,
  • Torsten Kniess,
  • Birgit Belter,
  • Christin Neuber,
  • Zhengxin Cai,
  • Gang Deng,
  • Steffen Fischer,
  • Jiangbing Zhou and
  • Yiyun Huang
  • + 3 authors

Sigma-1 receptors (Sig1R) are highly expressed in various human cancer cells and hence imaging of this target with positron emission tomography (PET) can contribute to a better understanding of tumor pathophysiology and support the development of ant...

  • Article
  • Open Access
18 Citations
6,578 Views
12 Pages

Association of Melatonin Production with Seasonal Changes, Low Temperature, and Immuno-Responses in Hamsters

  • Xiaoying Xu,
  • Xiaoyan Liu,
  • Shuran Ma,
  • Ya Xu,
  • Ying Xu,
  • Xiazhen Guo and
  • Dekui Li

Seasonal changes impact the melatonin production and immuno-activities in vertebrates. This is believed due to the photoperiodic alterations of the different seasons which impact the functions of pineal gland. The short photoperiod promotes pineal me...

  • Article
  • Open Access
29 Citations
7,742 Views
16 Pages

Xylobiose Prevents High-Fat Diet Induced Mice Obesity by Suppressing Mesenteric Fat Deposition and Metabolic Dysregulation

  • Soo-min Lim,
  • Eunju Kim,
  • Jae-Ho Shin,
  • Pu Reum Seok,
  • Sangwon Jung,
  • Sang-Ho Yoo and
  • Yuri Kim

Obesity is a public concern and is responsible for various metabolic diseases. Xylobiose (XB), an alternative sweetener, is a major component of xylo-oligosaccharide. The purpose of this study was to investigate the effects of XB on obesity and its a...

  • Article
  • Open Access
9 Citations
4,923 Views
17 Pages

Creeping bentgrass (Agrostis stolonifera) is the preferred green lawn grass, with excellent turf characteristics but poor disease resistance. At present, the mechanisms of disease resistance in creeping bentgrass are poorly understood, especially the...

  • Article
  • Open Access
52 Citations
9,439 Views
11 Pages

Antioxidant Activity of Coconut (Cocos nucifera L.) Protein Fractions

  • Yan Li,
  • Yajun Zheng,
  • Yufeng Zhang,
  • Jianguo Xu and
  • Gang Gao

Coconut cake is an abundant and good potential edible protein source. However, until now it has not been extensively used in the food industry. To promote its usage, the characterization, nutrition value and antioxidant activity of coconut cake prote...

  • Feature Paper
  • Article
  • Open Access
8 Citations
5,735 Views
11 Pages

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

  • Patrick Weber,
  • Seyed A. Nasseri,
  • Bettina M. Pabst,
  • Ana Torvisco,
  • Philipp Müller,
  • Eduard Paschke,
  • Marion Tschernutter,
  • Werner Windischhofer,
  • Stephen G. Withers and
  • Tanja M. Wrodnigg
  • + 1 author

From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibi...

  • Article
  • Open Access
21 Citations
6,430 Views
20 Pages

Diabetes Drug Discovery: hIAPP1–37 Polymorphic Amyloid Structures as Novel Therapeutic Targets

  • Isaac Fernández-Gómez,
  • Marquiza Sablón-Carrazana,
  • Alberto Bencomo-Martínez,
  • Guadalupe Domínguez,
  • Reyna Lara-Martínez,
  • Nelly F. Altamirano-Bustamante,
  • Luis Felipe Jiménez-García,
  • Karina Pasten-Hidalgo,
  • Rosa Angélica Castillo-Rodríguez and
  • Perla Altamirano
  • + 7 authors

Human islet amyloid peptide (hIAPP1–37) aggregation is an early step in Diabetes Mellitus. We aimed to evaluate a family of pharmaco-chaperones to act as modulators that provide dynamic interventions and the multi-target capacity (native state, cytot...

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Molecules - ISSN 1420-3049