Special Issue "Small Molecule Catalysts with Therapeutic Potential"
Deadline for manuscript submissions: closed (4 December 2017).
Interests: bioorganic chemistry; catalytic sensor/effector agents; epistemology; intracellular diagnostics; nanotechnology; natural products; reactive sulfur and selenium species; redox regulation via the cellular thiolstat
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Most diseases, from trivial infections to serious inflammation and proliferative disorders, exhibit characteristic intracellular disturbances that are notably absent under normal, healthy conditions. These small but significant biochemical differences in metabolites, such as Reactive Oxygen Species (ROS), pH, or other biomolecules, may enable us to selectively target such disorders. Here, catalysts provide an interesting lead, as they combine high efficiency with considerable selectivity, i.e., are able to “sense” the presence of particular metabolites, such as increased concentrations of ROS in the cell, and selectively develop their activity in the presence, but not in the absence, of such substrates. Placed in a living system, catalysts therefore may well metamorphose into intelligent “sensor/effector” agents, which (a) on their own are virtually inactive, (b) are able to recognize the presence of suitable biochemical substrates and hence distinguish between different cells, (c) act in low to sub-micromolar concentrations, and (d) affect the target cell in a highly-efficient manner.
Indeed, during the last decade, various small molecule catalysts with impressive biological activities and considerable pharmaceutical promise have been reported in the literature. It is now time to take stock of these developments and to consider the chemistry, biochemical action and overall activity of various types of small molecule catalysts, and the kind of disorders they may be employed against. This Special Issue will, therefore, bring together researchers and research from different disciplines focussing on such catalytic agents, and their ability to selectively target certain diseases.
Prof. Dr. Claus Jacob
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- redox modulation
- sensor/effector agent
- therapeutic activity