Special Issue "Plant Derived Natural Products and Age Related Diseases"
Deadline for manuscript submissions: closed (31 January 2018).
Prof. Alexios-Leandros Skaltsounis
National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacognosy and Chemistry of Natural Products, Athens, Greece
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Interests: “Green” chemistry and large-scale extraction of high added value natural products; Isolation of natural products leads; Identification and structure elucidation of natural products; Semi- and total- synthesis of natural products; Characterisation of natural extracts; Design and synthesis of new molecules with pharmacological interest; Structure-activity relationships
In the absence of overt disease, changes in nutrition and lifestyle are by far the most cost-efficient ways to promote healthy ageing at the population level. Ageing is a complex molecular process driven by diverse molecular pathways that are promoted by both environmental and genetic factors. Numerous studies show that natural compounds represent an amazing inventory of high diversity structural scaffolds that can offer promising candidates in the major healthcare challenge of increasing healthspan and delaying ageing. Especially plant derived compounds (either pure forms or extracts) are involved in several physiological processes and have been shown to possess significant beneficial (chemo-preventive/ delaying cellular senescence or in vivo ageing) effects on human health and to support healthy aging. Plants offer not only products of their primary metabolism, e.g., carbohydrates, proteins or lipids, but also a variety of biologically active secondary natural products (NPs) like polyphenols, essential oils, alkaloids, and many others which exhibit pleiotropic and, likely, therapeutic effects in humans. Today, it is assumed that the generation of NPs has been subjected to natural selection during evolution since the presence of particular secondary metabolite improves the capacity for survival and reproduction of the producing organism. Up to now, approximately 200,000 metabolites have been elucidated in plants and it is expected that the final number will exceed 500,000.
This Special Issue on “Natural Products and Age Related Diseases” will cover several aspects, such as:
- Medicinal plants used as diet with anti aging effects
- Plant collection, ethnopharmacology, benefit sharing
- Pharmacological aspects of aging
- Key modulators of ageing and age-associated related diseases
- Mechanism(s) of natural products in prevention of age-related disease
- Natural products affecting cellular aging signaling
- Advanced analytical approaches and techniques (microfractionation, microprobe-NMR, LC-SPE-NMR, LC-HR-MSn) and dereplication strategies
- In vitro and in vivo assays to identify bioactive extracts and NPs with health-span and longevity promoting effects
- Pharmacokinetics of NPs
- Gastrointestinal metabolisation of plant derived compounds
- Aging—computational tools and medicinal chemistry concepts in anti-aging research
Prof. Dr. Leandros A. Skaltsounis
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- natural products
- biological effects