G-Quadruplex Ligands and Cancer
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 March 2019) | Viewed by 134974
Special Issue Editor
Interests: DNA structures and functions; G-quadruplexes; anticancer drugs; NMR; ligand interactions
Special Issue Information
Dear Colleagues,
G-quadruplexes are four-stranded nucleic acid secondary structures, which form in guanine-rich DNA and RNA sequences. Once a laboratory curiosity, these non-canonical structures are now known to form readily under physiological conditions in regions of biological significance, such as human telomeres, oncogene promoter regions, replication initiation sites, and 5’ and 3’-untranslated (UTR) regions. Many G-quadruplex forming sequences are found to be associated with cancer, thus, these non-canonical nucleic acid structures are considered to be attractive molecular targets for cancer therapeutics with novel mechanisms of action. In recent years, G-quadruplexes have received elevated research interest, and G-quadruplex interactive ligands have been identified to exhibit antiproliferative and chemosensitizing effects against tumor models both in vitro and in vivo. Notably, quarfloxin, a G-quadruplex-interactive fluoroquinoline derivative, reached phase II clinical trials for the treatment of carcinoid/neuroendocrine tumors. While significant advances have been made towards targeting G-quadruplex structures, many questions and challenges on the subject remain to be addressed. This Special Issue aims to provide opportunity to share new findings and recent advances on G-quadruplex targeted small-molecules toward the development of new anticancer drugs.
Prof. Danzhou Yang
Guest Editor
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Keywords
- G-quadruplexes nucleic acid secondary structures
- molecular targets for cancer therapeutics
- G-quadruplex-targeted ligands
- anticancer and chemosensitizing effects
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