You are currently viewing a new version of our website. To view the old version click .

Molecules, Volume 21, Issue 7

July 2016 - 146 articles

Cover Story: Dynamic inhibitor discovery: Protein-directed dynamic combinatorial chemistry is a technique for the discovery of novel chemical structures that are important for the binding to a target protein or enzyme. Chemical diversity is generated through a library of small molecules, all of which contain functional groups that allow these small molecules to react reversibly with each other. The compound(s) that interact most strongly with the target protein will be amplified and can be detected by a suitable analytical technique. In this article, we reviewed recent literature examples to discuss the practical application of using this method to discover new protein ligands and enzyme inhibitors. View the paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (146)

  • Review
  • Open Access
175 Citations
13,940 Views
15 Pages

Metabolic Responses of Bacterial Cells to Immobilization

  • Joanna Żur,
  • Danuta Wojcieszyńska and
  • Urszula Guzik

In recent years immobilized cells have commonly been used for various biotechnological applications, e.g., antibiotic production, soil bioremediation, biodegradation and biotransformation of xenobiotics in wastewater treatment plants. Although the li...

  • Article
  • Open Access
19 Citations
8,018 Views
11 Pages

Qingxuan Jiangya Decoction (QXJYD), a traditional Chinese medicine formula prescribed by academician Ke-ji Chen, has been used in China to clinically treat hypertension for decades of years. However, the molecular mechanisms of its action remain larg...

  • Article
  • Open Access
29 Citations
6,755 Views
10 Pages

Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

  • Sri Devi Sukumaran,
  • Chin Fei Chee,
  • Geetha Viswanathan,
  • Michael J. C. Buckle,
  • Rozana Othman,
  • Noorsaadah Abd. Rahman and
  • Lip Yong Chung

A series of 2′-hydroxy- and 2′-hydroxy-4′,6′-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE). The majority of the compounds were found to show some activity, with the most active compounds having IC...

  • Article
  • Open Access
10 Citations
7,415 Views
23 Pages

Chlorophyll a Covalently Bonded to Organo-Modified Translucent Silica Xerogels: Optimizing Fluorescence and Maximum Loading

  • M. A. García-Sánchez,
  • I. N. Serratos,
  • R. Sosa,
  • T. Tapia-Esquivel,
  • F. González-García,
  • F. Rojas-González,
  • S. R. Tello-Solís,
  • A. Y. Palacios-Enriquez,
  • J. M. Esparza Schulz and
  • A. Arrieta

Chlorophyll is a pyrrolic pigment with important optical properties, which is the reason it has been studied for many years. Recently, interest has been rising with respect to this molecule because of its outstanding physicochemical properties, parti...

  • Article
  • Open Access
11 Citations
9,013 Views
13 Pages

Synthesis, Characterization, and Retinol Stabilization of Fatty Amide-β-cyclodextrin Conjugates

  • Hwanhee Kim,
  • Yiluo Hu,
  • Daham Jeong,
  • Bong-Hyun Jun,
  • Eunae Cho and
  • Seunho Jung

Amphiphilic cyclodextrin (CD) has been the object of growing scientific attention because of its two recognition sites, the cavity and the apolar heart, formed by self-assembly. In the present study, mono[6-deoxy-6-(octadecanamido)]-β-CD and mono[6-d...

  • Review
  • Open Access
681 Citations
34,284 Views
15 Pages

Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT...

  • Article
  • Open Access
21 Citations
5,850 Views
9 Pages

Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata

  • Qiao-Lin Xu,
  • Jing Wang,
  • Li-Mei Dong,
  • Qiang Zhang,
  • Bi Luo,
  • Yong-Xia Jia,
  • Hong-Feng Wang and
  • Jian-Wen Tan

Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3–7. They were all isolated from the leaves of A. trifoliata for the fi...

  • Short Note
  • Open Access
8 Citations
6,113 Views
9 Pages

Passerina del Frusinate is an autochthonous wine grape variety, which grows in the Lazio region that is currently being evaluated by local wine producers. In this study, colour properties (CIELab coordinates), bioactive compounds (total polyphenols a...

  • Article
  • Open Access
21 Citations
6,985 Views
15 Pages

New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity

  • Dorota G. Piotrowska,
  • Graciela Andrei,
  • Dominique Schols,
  • Robert Snoeck and
  • Magdalena Grabkowska-Drużyc

A novel series of (3-diethoxyphosphoryl)isoxazolidines substituted at C5 with various quinazolinones have been synthesized by the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N3-substitued 2-vinyl-3H-quinazolin-4-ones. All...

  • Review
  • Open Access
53 Citations
11,810 Views
40 Pages

Immobilized Lignin Peroxidase-Like Metalloporphyrins as Reusable Catalysts in Oxidative Bleaching of Industrial Dyes

  • Paolo Zucca,
  • Cláudia M. B. Neves,
  • Mário M. Q. Simões,
  • Maria Da Graça P. M. S. Neves,
  • Gianmarco Cocco and
  • Enrico Sanjust

Synthetic and bioinspired metalloporphyrins are a class of redox-active catalysts able to emulate several enzymes such as cytochromes P450, ligninolytic peroxidases, and peroxygenases. Their ability to perform oxidation and degradation of recalcitran...

of 15

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Molecules - ISSN 1420-3049