Table of Contents
Molecules, Volume 21, Issue 7 (July 2016)
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Cover Story (view full-size image) Dynamic inhibitor discovery: Protein-directed dynamic combinatorial chemistry is a technique for [...] Read more. Dynamic inhibitor discovery: Protein-directed dynamic combinatorial chemistry is a technique for the discovery of novel chemical structures that are important for the binding to a target protein or enzyme. Chemical diversity is generated through a library of small molecules, all of which contain functional groups that allow these small molecules to react reversibly with each other. The compound(s) that interact most strongly with the target protein will be amplified and can be detected by a suitable analytical technique. In this article, we reviewed recent literature examples to discuss the practical application of using this method to discover new protein ligands and enzyme inhibitors. View the paper