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Molecules 2016, 21(7), 965;

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, China
Author to whom correspondence should be addressed.
Academic Editor: Helena Vasconcelos
Received: 10 June 2016 / Revised: 16 July 2016 / Accepted: 19 July 2016 / Published: 22 July 2016
(This article belongs to the Special Issue New Approaches to Counteract Drug Resistance in Cancer)
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Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in cancer drug resistance has been increasingly recognized. Numerous EMT-related signaling pathways are involved in drug resistance in cancer cells. Cells undergoing EMT show a feature similar to cancer stem cells (CSCs), such as an increase in drug efflux pumps and anti-apoptotic effects. Therefore, targeting EMT has been considered a novel opportunity to overcome cancer drug resistance. This review describes the mechanism by which EMT contributes to drug resistance in cancer cells and summarizes new advances in research in EMT-associated drug resistance. View Full-Text
Keywords: epithelial–mesenchymal transition; drug resistance; chemotherapy; cancer stem cells epithelial–mesenchymal transition; drug resistance; chemotherapy; cancer stem cells

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Du, B.; Shim, J.S. Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules 2016, 21, 965.

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