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32 Results Found

  • Article
  • Open Access
4 Citations
2,900 Views
12 Pages

Effect of Fluoxetine and Acacetin on Central Vestibular Compensation in an Animal Model of Unilateral Peripheral Vestibulopathy

  • Bérénice Hatat,
  • Romain Boularand,
  • Claire Bringuier,
  • Nicolas Chanut and ,
  • Christian Chabbert and
  • Brahim Tighilet
  • + 1 author+ 0 author

Damage to the peripheral vestibular system is known to generate a syndrome characterized by postural, locomotor, oculomotor, perceptual and cognitive deficits. Current pharmacological therapeutic solutions for these pathologies lack specificity and e...

(This article belongs to the Special Issue Animal Models of Neurological Disorders: Where Are We Now?)
  • Article
  • Open Access
500 Views
16 Pages

Facial Nerve Palsy Recovery After Vestibular Schwannoma Surgery: Temporal Patterns and Early Predictors of Functional Outcome

  • Antonio Daloiso,
  • Anna Agostinelli,
  • Giusy Melcarne,
  • Silvia Montino and ,
  • Stefano Carraro,
  • Stefano Concheri,
  • Giulia Tealdo,
  • Diego Cazzador and
  • Elisabetta Zanoletti
  • + 4 authors+ 0 author

21 August 2026

Background and Objectives: Facial nerve palsy (FNP) remains a clinically relevant complication after vestibular schwannoma (VS) resection. Recovery trajectories vary according to the severity of neural injury and early postoperative facial function....

(This article belongs to the Section Neurology)
  • Article
  • Open Access
9 Citations
2,999 Views
16 Pages

SK Channels Modulation Accelerates Equilibrium Recovery in Unilateral Vestibular Neurectomized Rats

  • Brahim Tighilet,
  • Audrey Bourdet,
  • David Péricat,
  • Elise Timon-David and ,
  • Guillaume Rastoldo and
  • Christian Chabbert
  • + 1 author+ 0 author

26 November 2021

We have previously reported in a feline model of acute peripheral vestibulopathy (APV) that the sudden, unilateral, and irreversible loss of vestibular inputs induces selective overexpression of small conductance calcium-activated potassium (SK) chan...

(This article belongs to the Special Issue Ion Channels: Current Pharmacological Challenges)
  • Review
  • Open Access
878 Views
27 Pages

Optimizing Vestibular Rehabilitation: From Neuroplastic Mechanisms to Multimodal Therapeutic Strategies

  • Brahim Tighilet,
  • Emna Marouane,
  • Frédéric Xavier and
  • Christian Chabbert

18 August 2026

Peripheral vestibulopathy (PV) is a common disorder that causes dizziness and balance impairment, substantially affecting patients’ quality of life. When symptoms persist, they frequently lead to anxiety, depression, and an increased risk of so...

(This article belongs to the Special Issue Improving Diagnosis and Treatment of Vestibular Disorder: Latest Advances and Challenges)
  • Article
  • Open Access
17 Citations
4,706 Views
10 Pages

6 July 2022

Objectives. The aim was to analyze and compare the compensatory process, vestibular dysfunction, postural control, and perceived disability in a population of patients with vestibular neuritis (VN). Material and Methods. This is a prospective and lon...

(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Vestibular Disorders)
  • Article
  • Open Access
6 Citations
2,804 Views
19 Pages

17 January 2025

Objective: The aim was to evaluate vestibular function in patients with unilateral vestibular schwannoma before and in the short and medium term after surgical treatment to analyze vestibular compensation. The identification of the prognostic factors...

(This article belongs to the Section Otolaryngology)
  • Perspective
  • Open Access
18 Citations
11,928 Views
11 Pages

Updated Views on Vestibular Physical Therapy for Patients with Vestibular Disorders

  • Marco Tramontano,
  • Souad Haijoub,
  • Michel Lacour and
  • Leonardo Manzari

24 February 2025

Background/Objectives: Vestibular Physical Therapy (VPT) plays a crucial role in the rehabilitation of patients with vestibular disorders by promoting vestibular compensation through adaptation, habituation, and substitution mechanisms. While traditi...

(This article belongs to the Special Issue Outcome Measures and Innovative Approaches in Rehabilitation)
  • Article
  • Open Access
16 Citations
3,759 Views
28 Pages

Microglial Dynamics Modulate Vestibular Compensation in a Rodent Model of Vestibulopathy and Condition the Expression of Plasticity Mechanisms in the Deafferented Vestibular Nuclei

  • Nada El Mahmoudi,
  • Emna Marouane,
  • Guillaume Rastoldo,
  • David Pericat and ,
  • Isabelle Watabe,
  • Agnes Lapotre,
  • Alain Tonetto,
  • Christian Chabbert and
  • Brahim Tighilet
  • + 4 authors+ 0 author

29 August 2022

Unilateral vestibular loss (UVL) induces a vestibular syndrome composed of posturo-locomotor, oculomotor, vegetative, and perceptivo-cognitive symptoms. With time, these functional deficits progressively disappear due to a phenomenon called vestibula...

(This article belongs to the Special Issue Frontiers in Neuroinflammation)
  • Review
  • Open Access
4 Citations
2,625 Views
9 Pages

28 November 2024

Introduction and Objectives: Skull vibration-induced nystagmus (SVIN) has become a validated tool for evaluating the vestibular function. The presence of SVIN is a useful indicator of the asymmetry of vestibular function between the two ears. In unil...

(This article belongs to the Section Otolaryngology)
  • Case Report
  • Open Access
2,366 Views
20 Pages

Diagnosis of Isolated Saccular Dysfunction Using Trapezius cVEMP: A Detailed Vestibular Assessment

  • Mădălina Georgescu,
  • Oana Irina Popa,
  • Horațiu Ștefănescu,
  • Violeta Necula and ,
  • Alma Maniu,
  • Irina Enache and
  • Andrei Osman
  • + 2 authors+ 0 author

25 November 2025

Background and Clinical Significance: Vestibular disorders include a wide range of conditions with overlapping symptoms such as dizziness, vertigo and imbalance, often offering diagnostic challenges when distinguishing between peripheral and central...

(This article belongs to the Special Issue Research Updates in Vestibular Dysfunction: Diagnostic Breakthroughs)
  • Case Report
  • Open Access
4 Citations
3,815 Views
7 Pages

20 February 2022

Although radiologic methods confirm the diagnosis of patients with large vestibular schwannomas, these methods usually indicate only the size of the tumor and its possible nerve compression. Electrodiagnostic methods can reveal the functional state o...

(This article belongs to the Special Issue Evidence-Based Diagnosis and Management of Facial Nerve Disorders)
  • Article
  • Open Access
8 Citations
3,155 Views
12 Pages

Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation

  • Dan Liu,
  • Jun Wang,
  • Liuqing Zhou,
  • E Tian and ,
  • Jingyu Chen,
  • Weijia Kong,
  • Yisheng Lu and
  • Sulin Zhang
  • + 3 authors+ 0 author

Vestibular compensation is a natural behavioral recovery process following unilateral vestibular injury. Understanding the mechanism can considerably enhance vestibular disorder therapy and advance the adult central nervous system functional plastici...

(This article belongs to the Section Neurobiology and Clinical Neuroscience)
  • Article
  • Open Access
913 Views
24 Pages

Background: Vestibular tests are critical for an early detection of balance disorders, thereby reducing the risk of falls, particularly in older adults. The present is an ecologic study where the units of observation are the Italian Regions. Regional...

(This article belongs to the Section Healthcare Organizations, Systems, and Providers)
  • Review
  • Open Access
3 Citations
9,888 Views
15 Pages

13 June 2024

In patients presenting in the emergency department with acute vertigo, a rapid and accurate differential diagnosis is crucial, as posterior circulation strokes can mimic acute vestibular losses, leading to inappropriate treatment. The diagnosis of ve...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
1,868 Views
24 Pages

Non-Implantable Prosthetic Devices to Stabilize Posture and Body Balance

  • Gustavo Arellano,
  • Adriana Pliego and
  • Enrique Soto

This is a narrative review that explores the development of non-implantable vestibular devices designed to address postural instability, particularly in aging populations and patients with vestibular hypofunction. It establishes that balance relies o...

  • Article
  • Open Access
9 Citations
5,362 Views
25 Pages

4 November 2024

Background: Vestibular Neuritis (VN) can induce unilateral acute vestibular syndrome (AVS). This study aimed to identify predictive factors of recovery from vestibular neuritis considering total restitution and/or compensation. Methods: In this longi...

  • Article
  • Open Access
10 Citations
4,270 Views
16 Pages

PtNPs/PEDOT:PSS-Modified Microelectrode Arrays for Detection of the Discharge of Head Direction Cells in the Retrosplenial Cortex of Rats under Dissociation between Visual and Vestibular Inputs

  • Gucheng Yang,
  • Yiding Wang,
  • Zhaojie Xu,
  • Xue Zhang and ,
  • Wang Ruan,
  • Fan Mo,
  • Botao Lu,
  • Penghui Fan,
  • Yuchuan Dai and
  • Xinxia Cai
  • + 9 authors+ 4 authors

23 April 2023

The electrophysiological activities of head direction (HD) cells under visual and vestibular input dissociation are important to understanding the formation of the sense of direction in animals. In this paper, we fabricated a PtNPs/PEDOT:PSS-modified...

(This article belongs to the Special Issue New Biosensors and Nanosensors)
  • Systematic Review
  • Open Access
5 Citations
2,529 Views
29 Pages

Sex and Gender Aspects in Vestibular Disorders: Current Knowledge and Emerging Perspectives—A Systematic Review

  • Leonardo Franz,
  • Andrea Frosolini,
  • Daniela Parrino,
  • Giulio Badin and ,
  • Chiara Pavone,
  • Roberta Cenedese,
  • Agnese Vitturi,
  • Margherita Terenzani,
  • Charles Nicholas Babb and
  • Gino Marioni
  • + 7 authors+ 2 authors

Background/Objectives: As precision medicine advances, attention to sex and gender determinants across epidemiological and clinical domains has intensified. However, in the audio-vestibular field, knowledge on sex- and gender-related aspects remains...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Review
  • Open Access
2,248 Views
20 Pages

Evolution of Multifaceted Sport-Related Concussion Management: A 25-Year Narrative Review of Multidomain Assessment and Multimodal Rehabilitation

  • James Stavitz,
  • Kenneth Swan,
  • Adam Eckart,
  • Thomas Koc and ,
  • Jenna Tucker,
  • Jennifer T. Gentile,
  • Pragya Sharma Ghimire and
  • Ryan Porcelli
  • + 3 authors+ 0 author

13 March 2026

Context: Sport-related concussion (SRC) management has evolved substantially over the past 25 years. Early paradigms emphasized prolonged physical and cognitive rest; however, growing evidence has demonstrated that recovery following SRC is multidime...

(This article belongs to the Special Issue Sport-Related Concussion and Head Impact in Athletes)
  • Case Report
  • Open Access
1,363 Views
7 Pages

10 February 2026

Objective: Bilateral cleft lip and palate (BCLP) is a craniofacial malformation often associated with anatomical and functional impairments, including a shallow oral vestibule in the premaxillary region. This condition requires a vestibuloplasty to r...

  • Review
  • Open Access
684 Views
26 Pages

Unravelling the Impact of Microgravity on Calcium Ion Signaling and Sensorium in Spaceflight

  • Lin Marza,
  • Roula Mohammed,
  • Yousif Abdelrahman,
  • Abdullah Hajjiri and ,
  • Malek Abuhjar and
  • G. Roshan Deen
  • + 1 author+ 0 author

30 June 2026

Human spaceflight in microgravity induces profound physiological adaptations, yet its effects on the sensory system remain comparatively underexplored. While musculoskeletal and cardiovascular changes are well documented, sensory alterations pose equ...

(This article belongs to the Section Physiology and Pathology)
  • Protocol
  • Open Access
6 Citations
3,688 Views
14 Pages

Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia—A Mixed Method Prospective Cohort and Nested Case–Control Study: Study Protocol

  • Rosalia Dacosta-Aguayo,
  • Noemí Lamonja-Vicente,
  • Carla Chacón,
  • Lucia Amalía Carrasco-Ribelles and ,
  • Pilar Montero-Alia,
  • Anna Costa-Garrido,
  • Rosa García-Sierra,
  • Victor M. López-Lifante,
  • Eduard Moreno-Gabriel and
  • Pere Torán-Monserrat
  • + 15 authors+ 10 authors

The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessa...

(This article belongs to the Section Pathogens-Host Immune Boundaries)
  • Review
  • Open Access
509 Views
19 Pages

22 July 2026

Sport-related concussion (SRC) rehabilitation has advanced toward active, multidomain management, yet recovery may still be judged largely through symptom resolution and broad clinical indicators that may not fully capture persistent functional defic...

(This article belongs to the Special Issue Biofeedback Applications and Symmetry in Rehabilitation, Sports and Ergonomics)
  • Article
  • Open Access
3 Citations
3,088 Views
23 Pages

6 August 2025

With the development of inspection robot control technology, wheel-legged robots are increasingly used in complex underground space inspection. To address low stability during obstacle crossing in unstructured terrains, a motion control strategy inte...

  • Article
  • Open Access
9 Citations
5,847 Views
22 Pages

Inertial Measurement of Head Tilt in Rodents: Principles and Applications to Vestibular Research

  • Romain Fayat,
  • Viviana Delgado Betancourt,
  • Thibault Goyallon,
  • Mathieu Petremann and ,
  • Pauline Liaudet,
  • Vincent Descossy,
  • Lionel Reveret and
  • Guillaume P. Dugué
  • + 3 authors+ 0 author

21 September 2021

Inertial sensors are increasingly used in rodent research, in particular for estimating head orientation relative to gravity, or head tilt. Despite this growing interest, the accuracy of tilt estimates computed from rodent head inertial data has neve...

(This article belongs to the Special Issue Advances in Inertial Sensors)
  • Review
  • Open Access
109 Citations
17,259 Views
27 Pages

21 July 2020

Hearing impairment is the most frequent sensory deficit in humans of all age groups, from children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital deafness are hereditary in nature. The other major causes of deafness,...

(This article belongs to the Special Issue Therapies for Hearing Loss)
  • Case Report
  • Open Access
602 Views
16 Pages

31 August 2026

Persistent post-concussion syndrome (PPCS) develops in 10 to 30 percent of patients following mild traumatic brain injury (mTBI), yet the most effective management approach remains an open question. This report describes a 37-year-old female who sust...

(This article belongs to the Special Issue The Future of Neurorehabilitation: Novel Approaches and Personalized Medicine)
  • Article
  • Open Access
2 Citations
3,636 Views
12 Pages

MRI-Based Inner Ear Assessment and Cochlin Tomoprotein-Based Evaluation of Perilymphatic Fistula in Patients with Sudden Hearing Loss

  • Rayoung Kim,
  • Denis Mihailovic,
  • Conrad Riemann,
  • Alexander Kilgué and ,
  • Christoph Joachim Pfeiffer,
  • Hans-Björn Gehl,
  • Lars-Uwe Scholtz and
  • Ingo Todt
  • + 3 authors+ 0 author

Objectives: To study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. Study Design: Prospective case series. Metho...

(This article belongs to the Special Issue Recent Advances in Hearing Impairment)
  • Review
  • Open Access
6,523 Views
22 Pages

Multidisciplinary Management of Cerebellopontine Angle Tumors with Brainstem Involvement

  • Concheri Stefano,
  • Vito Pontillo,
  • Alberto D’Amico,
  • Stefano Di Girolamo and ,
  • Francesco Signorelli,
  • Elisabetta Zanoletti and
  • Nicola Antonio Adolfo Quaranta
  • + 2 authors+ 0 author

Background/Objectives: Tumors of the cerebellopontine angle (CPA) encompass a limited range of histologies, predominantly vestibular schwannomas (VSs), meningiomas, and paragangliomas (PGLs). Their growth region threatens the cranial nerves (V–...

(This article belongs to the Special Issue Impact of Brainstem Diseases on Hearing, Balance, Speech and Swallowing)
  • Article
  • Open Access
1 Citations
3,377 Views
13 Pages

Assessing the Efficacy of Anastomosis between Ansa Cervicalis and Facial Nerve for Patients with Concomitant Facial Palsy and Peripheral Neuropathy

  • Georgeta Magdalena Balaci,
  • Aurel Oṣlobanu,
  • Zoltán Zsigmond Major,
  • Réka Emma Dávid and ,
  • Maria Iepure,
  • Daniela Hancu,
  • Adina Mihaela Popa and
  • Ioan Ṣtefan Florian
  • + 3 authors+ 0 author

29 December 2022

Background: For decades, patients with facial asymmetry have experienced social interaction difficulties, leading them to seek treatment in the hope of restoring facial symmetry and quality of life. Researchers evaluated numerous surgical techniques,...

  • Article
  • Open Access
12 Citations
4,547 Views
9 Pages

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors

  • Edward S. A. van Beelen,
  • Wouter H. van der Valk,
  • Thijs O. Verhagen,
  • John C. M. J. de Groot and ,
  • Margot A. Madison,
  • Wijs Shadmanfar,
  • Erik F. Hensen,
  • Jeroen C. Jansen,
  • Peter Paul G. van Benthem and
  • Heiko Locher
  • + 6 authors+ 1 author

10 June 2022

Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated. One limitation has been the lack of human inner ear cell li...

(This article belongs to the Special Issue Inner Ear Therapeutics)
  • Review
  • Open Access
3 Citations
2,166 Views
13 Pages

Objective Markers for Diagnosing Concussions: Beyond Blood Biomarkers and the Role of Real-Time Diagnostic Tools

  • Robert Kamil,
  • Youssef Atef AbdelAlim,
  • Shiv Patel,
  • Paxton Sweeney and ,
  • Harry Feng,
  • Jasdeep Hundal and
  • Ira Goldstein
  • + 2 authors+ 0 author

30 October 2025

Concussions, classified as a type of mild traumatic brain injury (mTBI), are frequently underdiagnosed due to the subjective nature of symptoms and limitations in existing diagnostic methodologies. Current clinical evaluations, including tools such a...

(This article belongs to the Section Brain Injury)