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23 Results Found

  • Article
  • Open Access
4 Citations
2,450 Views
12 Pages

Effect of Fluoxetine and Acacetin on Central Vestibular Compensation in an Animal Model of Unilateral Peripheral Vestibulopathy

  • Bérénice Hatat,
  • Romain Boularand,
  • Claire Bringuier,
  • Nicolas Chanut,
  • Christian Chabbert and
  • Brahim Tighilet

Damage to the peripheral vestibular system is known to generate a syndrome characterized by postural, locomotor, oculomotor, perceptual and cognitive deficits. Current pharmacological therapeutic solutions for these pathologies lack specificity and e...

  • Article
  • Open Access
8 Citations
2,644 Views
16 Pages

SK Channels Modulation Accelerates Equilibrium Recovery in Unilateral Vestibular Neurectomized Rats

  • Brahim Tighilet,
  • Audrey Bourdet,
  • David Péricat,
  • Elise Timon-David,
  • Guillaume Rastoldo and
  • Christian Chabbert

26 November 2021

We have previously reported in a feline model of acute peripheral vestibulopathy (APV) that the sudden, unilateral, and irreversible loss of vestibular inputs induces selective overexpression of small conductance calcium-activated potassium (SK) chan...

  • Article
  • Open Access
10 Citations
3,900 Views
10 Pages

6 July 2022

Objectives. The aim was to analyze and compare the compensatory process, vestibular dysfunction, postural control, and perceived disability in a population of patients with vestibular neuritis (VN). Material and Methods. This is a prospective and lon...

  • Article
  • Open Access
4 Citations
1,700 Views
19 Pages

17 January 2025

Objective: The aim was to evaluate vestibular function in patients with unilateral vestibular schwannoma before and in the short and medium term after surgical treatment to analyze vestibular compensation. The identification of the prognostic factors...

  • Perspective
  • Open Access
7 Citations
9,094 Views
11 Pages

Updated Views on Vestibular Physical Therapy for Patients with Vestibular Disorders

  • Marco Tramontano,
  • Souad Haijoub,
  • Michel Lacour and
  • Leonardo Manzari

24 February 2025

Background/Objectives: Vestibular Physical Therapy (VPT) plays a crucial role in the rehabilitation of patients with vestibular disorders by promoting vestibular compensation through adaptation, habituation, and substitution mechanisms. While traditi...

  • Article
  • Open Access
11 Citations
3,221 Views
28 Pages

Microglial Dynamics Modulate Vestibular Compensation in a Rodent Model of Vestibulopathy and Condition the Expression of Plasticity Mechanisms in the Deafferented Vestibular Nuclei

  • Nada El Mahmoudi,
  • Emna Marouane,
  • Guillaume Rastoldo,
  • David Pericat,
  • Isabelle Watabe,
  • Agnes Lapotre,
  • Alain Tonetto,
  • Christian Chabbert and
  • Brahim Tighilet

29 August 2022

Unilateral vestibular loss (UVL) induces a vestibular syndrome composed of posturo-locomotor, oculomotor, vegetative, and perceptivo-cognitive symptoms. With time, these functional deficits progressively disappear due to a phenomenon called vestibula...

  • Review
  • Open Access
1 Citations
2,039 Views
9 Pages

28 November 2024

Introduction and Objectives: Skull vibration-induced nystagmus (SVIN) has become a validated tool for evaluating the vestibular function. The presence of SVIN is a useful indicator of the asymmetry of vestibular function between the two ears. In unil...

  • Case Report
  • Open Access
1,208 Views
20 Pages

Diagnosis of Isolated Saccular Dysfunction Using Trapezius cVEMP: A Detailed Vestibular Assessment

  • Mădălina Georgescu,
  • Oana Irina Popa,
  • Horațiu Ștefănescu,
  • Violeta Necula,
  • Alma Maniu,
  • Irina Enache and
  • Andrei Osman

25 November 2025

Background and Clinical Significance: Vestibular disorders include a wide range of conditions with overlapping symptoms such as dizziness, vertigo and imbalance, often offering diagnostic challenges when distinguishing between peripheral and central...

  • Case Report
  • Open Access
4 Citations
3,391 Views
7 Pages

20 February 2022

Although radiologic methods confirm the diagnosis of patients with large vestibular schwannomas, these methods usually indicate only the size of the tumor and its possible nerve compression. Electrodiagnostic methods can reveal the functional state o...

  • Article
  • Open Access
6 Citations
2,695 Views
12 Pages

Differential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation

  • Dan Liu,
  • Jun Wang,
  • Liuqing Zhou,
  • E Tian,
  • Jingyu Chen,
  • Weijia Kong,
  • Yisheng Lu and
  • Sulin Zhang

Vestibular compensation is a natural behavioral recovery process following unilateral vestibular injury. Understanding the mechanism can considerably enhance vestibular disorder therapy and advance the adult central nervous system functional plastici...

  • Review
  • Open Access
1 Citations
7,636 Views
15 Pages

13 June 2024

In patients presenting in the emergency department with acute vertigo, a rapid and accurate differential diagnosis is crucial, as posterior circulation strokes can mimic acute vestibular losses, leading to inappropriate treatment. The diagnosis of ve...

  • Article
  • Open Access
4 Citations
3,594 Views
25 Pages

4 November 2024

Background: Vestibular Neuritis (VN) can induce unilateral acute vestibular syndrome (AVS). This study aimed to identify predictive factors of recovery from vestibular neuritis considering total restitution and/or compensation. Methods: In this longi...

  • Article
  • Open Access
6 Citations
3,757 Views
16 Pages

PtNPs/PEDOT:PSS-Modified Microelectrode Arrays for Detection of the Discharge of Head Direction Cells in the Retrosplenial Cortex of Rats under Dissociation between Visual and Vestibular Inputs

  • Gucheng Yang,
  • Yiding Wang,
  • Zhaojie Xu,
  • Xue Zhang,
  • Wang Ruan,
  • Fan Mo,
  • Botao Lu,
  • Penghui Fan,
  • Yuchuan Dai and
  • Xinxia Cai
  • + 4 authors

23 April 2023

The electrophysiological activities of head direction (HD) cells under visual and vestibular input dissociation are important to understanding the formation of the sense of direction in animals. In this paper, we fabricated a PtNPs/PEDOT:PSS-modified...

  • Systematic Review
  • Open Access
417 Views
29 Pages

Sex and Gender Aspects in Vestibular Disorders: Current Knowledge and Emerging Perspectives—A Systematic Review

  • Leonardo Franz,
  • Andrea Frosolini,
  • Daniela Parrino,
  • Giulio Badin,
  • Chiara Pavone,
  • Roberta Cenedese,
  • Agnese Vitturi,
  • Margherita Terenzani,
  • Charles Nicholas Babb and
  • Gino Marioni
  • + 2 authors

Background/Objectives: As precision medicine advances, attention to sex and gender determinants across epidemiological and clinical domains has intensified. However, in the audio-vestibular field, knowledge on sex- and gender-related aspects remains...

  • Protocol
  • Open Access
6 Citations
3,353 Views
14 Pages

Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia—A Mixed Method Prospective Cohort and Nested Case–Control Study: Study Protocol

  • Rosalia Dacosta-Aguayo,
  • Noemí Lamonja-Vicente,
  • Carla Chacón,
  • Lucia Amalía Carrasco-Ribelles,
  • Pilar Montero-Alia,
  • Anna Costa-Garrido,
  • Rosa García-Sierra,
  • Victor M. López-Lifante,
  • Eduard Moreno-Gabriel and
  • Pere Torán-Monserrat
  • + 10 authors

The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessa...

  • Article
  • Open Access
1 Citations
2,029 Views
23 Pages

6 August 2025

With the development of inspection robot control technology, wheel-legged robots are increasingly used in complex underground space inspection. To address low stability during obstacle crossing in unstructured terrains, a motion control strategy inte...

  • Article
  • Open Access
8 Citations
4,864 Views
22 Pages

Inertial Measurement of Head Tilt in Rodents: Principles and Applications to Vestibular Research

  • Romain Fayat,
  • Viviana Delgado Betancourt,
  • Thibault Goyallon,
  • Mathieu Petremann,
  • Pauline Liaudet,
  • Vincent Descossy,
  • Lionel Reveret and
  • Guillaume P. Dugué

21 September 2021

Inertial sensors are increasingly used in rodent research, in particular for estimating head orientation relative to gravity, or head tilt. Despite this growing interest, the accuracy of tilt estimates computed from rodent head inertial data has neve...

  • Review
  • Open Access
103 Citations
15,767 Views
27 Pages

21 July 2020

Hearing impairment is the most frequent sensory deficit in humans of all age groups, from children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital deafness are hereditary in nature. The other major causes of deafness,...

  • Article
  • Open Access
2 Citations
2,799 Views
12 Pages

MRI-Based Inner Ear Assessment and Cochlin Tomoprotein-Based Evaluation of Perilymphatic Fistula in Patients with Sudden Hearing Loss

  • Rayoung Kim,
  • Denis Mihailovic,
  • Conrad Riemann,
  • Alexander Kilgué,
  • Christoph Joachim Pfeiffer,
  • Hans-Björn Gehl,
  • Lars-Uwe Scholtz and
  • Ingo Todt

Objectives: To study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. Study Design: Prospective case series. Metho...

  • Review
  • Open Access
683 Views
22 Pages

Multidisciplinary Management of Cerebellopontine Angle Tumors with Brainstem Involvement

  • Concheri Stefano,
  • Vito Pontillo,
  • Alberto D’Amico,
  • Stefano Di Girolamo,
  • Francesco Signorelli,
  • Elisabetta Zanoletti and
  • Nicola Antonio Adolfo Quaranta

Background/Objectives: Tumors of the cerebellopontine angle (CPA) encompass a limited range of histologies, predominantly vestibular schwannomas (VSs), meningiomas, and paragangliomas (PGLs). Their growth region threatens the cranial nerves (V–...

  • Article
  • Open Access
2,695 Views
13 Pages

Assessing the Efficacy of Anastomosis between Ansa Cervicalis and Facial Nerve for Patients with Concomitant Facial Palsy and Peripheral Neuropathy

  • Georgeta Magdalena Balaci,
  • Aurel Oṣlobanu,
  • Zoltán Zsigmond Major,
  • Réka Emma Dávid,
  • Maria Iepure,
  • Daniela Hancu,
  • Adina Mihaela Popa and
  • Ioan Ṣtefan Florian

29 December 2022

Background: For decades, patients with facial asymmetry have experienced social interaction difficulties, leading them to seek treatment in the hope of restoring facial symmetry and quality of life. Researchers evaluated numerous surgical techniques,...

  • Article
  • Open Access
9 Citations
4,032 Views
9 Pages

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors

  • Edward S. A. van Beelen,
  • Wouter H. van der Valk,
  • Thijs O. Verhagen,
  • John C. M. J. de Groot,
  • Margot A. Madison,
  • Wijs Shadmanfar,
  • Erik F. Hensen,
  • Jeroen C. Jansen,
  • Peter Paul G. van Benthem and
  • Heiko Locher
  • + 1 author

10 June 2022

Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated. One limitation has been the lack of human inner ear cell li...

  • Review
  • Open Access
879 Views
13 Pages

Objective Markers for Diagnosing Concussions: Beyond Blood Biomarkers and the Role of Real-Time Diagnostic Tools

  • Robert Kamil,
  • Youssef Atef AbdelAlim,
  • Shiv Patel,
  • Paxton Sweeney,
  • Harry Feng,
  • Jasdeep Hundal and
  • Ira Goldstein

30 October 2025

Concussions, classified as a type of mild traumatic brain injury (mTBI), are frequently underdiagnosed due to the subjective nature of symptoms and limitations in existing diagnostic methodologies. Current clinical evaluations, including tools such a...