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17 Results Found

  • Feature Paper
  • Article
  • Open Access
42 Citations
4,267 Views
10 Pages

29 March 2020

Monte Carlo simulations were used to predict the dose enhancement ratio (DER) using the flattening-filter-free (FFF) and flattening-filter (FF) photon beams in prostate nanoparticle-enhanced radiotherapy, with multiple variables such as nanoparticle...

  • Article
  • Open Access
1 Citations
2,591 Views
12 Pages

21 January 2023

Purpose: This study aimed to compare the dosimetric results of flattening filter-free (FFF) vs. flattened (FF) treatment plans for fractionated stereotactic radiotherapy (fSRT), with the goal to highlight potential advantages of FFF beams. Methods: A...

  • Article
  • Open Access
28 Citations
3,454 Views
9 Pages

Our team evaluated contrast enhancement for portal imaging using Monte Carlo simulation in nanoparticle-enhanced radiotherapy. Dependencies of percentage contrast enhancement on flattening-filter (FF) and flattening-filter-free (FFF) photon beams wer...

  • Article
  • Open Access
9 Citations
3,051 Views
8 Pages

8 September 2022

(1) Background: The Exradin W2 is a commercially available scintillator detector designed for reference and relative dosimetry in small fields. In this work, we investigated the performance of the W2 scintillator in a 10 MV flattening-filter-free pho...

  • Article
  • Open Access
21 Citations
3,251 Views
10 Pages

11 October 2020

The aim of this study is to investigate the variations of depth dose enhancement (DDE) on different nanoparticle (NP) variables, when using the flattening-filter-free (FFF) photon beam in nanoparticle-enhanced radiotherapy. Monte Carlo simulation und...

  • Article
  • Open Access
8 Citations
2,825 Views
11 Pages

15 October 2022

Purpose: This phantom study investigated through Monte Carlo simulation how the dose enhancement varied with depth, when gold nanoparticles (NPs) were added using the flattening filter-free (FFF) photon beams in gold NP-enhanced radiotherapy. Method:...

  • Article
  • Open Access
11 Citations
4,843 Views
13 Pages

SBRT for Localized Prostate Cancer: CyberKnife vs. VMAT-FFF, a Dosimetric Study

  • Marcello Serra,
  • Fortuna De Martino,
  • Federica Savino,
  • Valentina D’Alesio,
  • Cecilia Arrichiello,
  • Maria Quarto,
  • Filomena Loffredo,
  • Rossella Di Franco,
  • Valentina Borzillo and
  • Matteo Muto
  • + 2 authors

10 May 2022

In recent years, stereotactic body radiation therapy (SBRT) has gained popularity among clinical methods for the treatment of medium and low risk prostate cancer (PCa), mainly as an alternative to surgery. The hypo-fractionated regimen allows the adm...

  • Article
  • Open Access
25 Citations
4,435 Views
25 Pages

19 October 2019

The photon induced radical-initiated polymerization in polymer gels can be used for high-resolution tissue equivalent dosimeters in quality control of radiation therapy. The dose (D) distribution in radiation therapy can be measured as a change of th...

  • Article
  • Open Access
3 Citations
3,059 Views
21 Pages

Effectiveness of Flattening-Filter-Free versus Flattened Beams in V79 and Glioblastoma Patient-Derived Stem-like Cells

  • Valentina Dini,
  • Giuseppe Esposito,
  • Andrea Sacconi,
  • Marco D’Andrea,
  • Maria Antonella Tabocchini,
  • Pasquale Anello,
  • Lucia Ricci-Vitiani,
  • Mariachiara Buccarelli,
  • Roberto Pallini and
  • Lidia Strigari

Literature data on the administration of conventional high-dose beams with (FF) or without flattening filters (FFF) show conflicting results on biological effects at the cellular level. To contribute to this field, we irradiated V79 Chinese hamster l...

  • Article
  • Open Access
1 Citations
1,833 Views
14 Pages

Dosimetric Study of Flattened Versus Unflattened Filter-Free Medical Linear Accelerator: Experimental Measurements and Monte Carlo Calculations

  • Mohammed Halato,
  • Ibrahim I. Suliman,
  • Abdelmonim Artoli,
  • Francesco Longo and
  • Gianrossano Giannini

A dosimetric study compared flattened filter (FF) and unflattened filter-free (FFF) 18 MV medical linear accelerators (LINAC) using BEAMnrc Monte Carlo (MC) calculations and experimental measurements. BEAMnrc MC simulations were initially validated a...

  • Article
  • Open Access
1,308 Views
14 Pages

Modelling of linear accelerators using the Monte Carlo method is critical for precise radiotherapy planning. In addition, detailed and accurate dose estimation to the organ at risk can be assessed and optimized. In this study, EGSnrc Monte Carlo code...

  • Article
  • Open Access
89 Views
18 Pages

Modeling a 6 MV FFF Beam from the CyberKnife M6 to Produce Data for Training Artificial Neural Networks

  • Justyna Rostocka,
  • Joanna Prażmowska,
  • Adam Konefał,
  • Agnieszka Kapłon,
  • Andrzej Orlef and
  • Maria Sokół

18 December 2025

A Monte Carlo-based model of the CyberKnife M6 6 MV Flattening Filter-Free (FFF) beam was developed to produce the data that can be used to train artificial neural networks. The data include the energy spectra of the beam, its average energy, the spa...

  • Article
  • Open Access
7 Citations
4,132 Views
12 Pages

14 January 2023

Herein, we evaluated the neutron and gamma capture dose equivalent rates at the maze entrance of Varian TrueBeam and Elekta Versa HD™ medical linear accelerators (linacs) using experimental measurements as well as empirical calculations. Dose r...

  • Brief Report
  • Open Access
3 Citations
2,425 Views
10 Pages

Phase II Trial of LINAC-Based STereotactic Arrhythmia Radioablation (STAR) for Paroxysmal Atrial Fibrillation in Elderly: Planning and Dosimetric Point of View

  • Ilaria Bonaparte,
  • Fabiana Gregucci,
  • Antonio Di Monaco,
  • Federica Troisi,
  • Alessia Surgo,
  • Elena Ludovico,
  • Roberta Carbonara,
  • Eleonora Paulicelli,
  • Giuseppe Sanfrancesco and
  • Christian De Pascali
  • + 9 authors

29 March 2023

Purpose: Approaching treatment for elderly patients with atrial fibrillation is difficult. A prospective phase II trial evaluating LINAC-based stereotactic arrhythmia radioablation (STAR) safety in this population started in 2021. Dosimetric and plan...

  • Article
  • Open Access
2 Citations
1,828 Views
14 Pages

Evaluation of a Scintillating Plastic Optical Fiber Device for Measuring kV-Cone Beam Computed Tomography Dose

  • Christian Popotte,
  • Romain Letellier,
  • Didier Paul,
  • Alexandre Waltener,
  • Nicolas Guillochon,
  • Mélodie Munier and
  • Paul Retif

9 September 2023

Background: Justification of imaging procedures such as cone beam computed tomography (CBCT) in radiotherapy makes no doubt. However, the CBCT composite dose is rarely reported or optimized, even though the repeated CBCT cumulative dose can be up to...

  • Article
  • Open Access
3 Citations
2,894 Views
18 Pages

Surface Photonic Crystal Engineering of a Multi-Mode VCSEL for a Bit-Loaded Broadband QAM-OFDM Data Link at 99 Gbit/s

  • Yu-Hong Lin,
  • Chih-Hsien Cheng,
  • Cheng-Ting Tsai,
  • Wei-Li Wu,
  • Kent D. Choquette and
  • Gong-Ru Lin

Bit-loaded quadrature amplitude modulation-orthogonal frequency division multiplexing (QAM-OFDM) encoding and photonic-crystal-engineered multi-mode vertical-cavity surface-emitting lasers (MM-VCSELs) transmission performance are analyzed. Two differ...

  • Article
  • Open Access
1 Citations
2,573 Views
13 Pages

Electromagnetic Transmitter-Based Prostate Gating for Dose-Escalated Linac-Based Stereotactic Body Radiation Therapy: An Evaluation of Intrafraction Motion

  • Berardino De Bari,
  • Geoffroy Guibert,
  • Sabrine Slimani,
  • Yanes Bashar,
  • Terence Risse,
  • Nicole Guisolan,
  • Juliane Trouillot,
  • Jonathan Abel and
  • Patrick Weber

9 February 2024

Background: Stereotactic Body Radiotherapy (SBRT) is as a standard treatment for prostate cancer (PCa). Tight margins and high dose gradients are needed, and the precise localization of the target is mandatory. Our retrospective study reports our exp...