Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 547

Special Issue Editors


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Guest Editor
Grupo de Pesquisa em Doenças Metabólicas (GPDM), Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Universidade Federal do Paraná, Curitiba 80210-170, PR, Brazil
Interests: nano-based formulations; inflammation; pain management

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Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Center for Studies in Bio-Pharmacy, Federal University of Paraná, Curitiba 80210-170, Brazil
Interests: drug delivery systems; pharmacokinetics; drug monitoring; health technology assessment; drug safety; natural products

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Guest Editor Assistant
Center for Studies in Bio-Pharmacy, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba 80210-170, PR, Brazil
Interests: drug delivery systems; pharmacokinetics; health technology assessment; drug safety; clinical pharmacology; natural products
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Special Issue Information

Dear Colleagues,

Skin disorders represent a significant burden on global healthcare systems, affecting millions of individuals and requiring innovative therapeutic strategies. Advances in biotechnological formulations have paved the way for more effective and targeted treatments for various dermatological conditions. These approaches emphasize biocompatibility, sustained release, and improved skin penetration, ensuring greater efficacy and patient adherence. In particular, the integration of cutting-edge delivery systems, natural ingredients, and biopolymers into these therapies has revolutionized the dermatological landscape, opening up new possibilities in addressing inflammatory, infectious, and chronic skin disorders.

This Special Issue, “Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility,” will provide a platform for disseminating the latest findings in the field of dermatological formulation science. We welcome original research articles and reviews exploring innovative delivery systems and their applications in treating skin disorders, emphasizing formulation and biocompatibility evaluations.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Nanocarriers, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and polymeric nanoparticles, designed to allow enhanced penetration and controlled drug release in skin applications;
  • Formulations incorporating probiotics to restore skin microbiome balance and treat conditions such as acne, dermatitis, and psoriasis;
  • Biotechnological approaches utilizing natural products, including plant-derived bioactive compounds, essential oils, and extracts with antioxidant, anti-inflammatory, and antimicrobial properties;
  • The use of biopolymers, such as polysaccharides and other natural gums, in innovative formulations like hydrogels, films, and emulsions for wound healing and barrier restoration;
  • Mechanistic studies on skin absorption, tissue interaction, and the role of formulation excipients in enhancing therapeutic outcomes;
  • The evaluation of the safety, efficacy, and stability of novel formulations using in vitro, ex vivo, and in vivo models;
  • Applications of advanced formulations in chronic skin conditions, infections, wound management, and cosmetic dermatology

This Special Issue will foster interdisciplinary dialog and share breakthroughs in the development of novel delivery strategies for managing skin disorders. Submissions emphasizing biotechnological innovation, biocompatibility, and translational potential are particularly encouraged.

We look forward to receiving your contributions to this exciting field of research.

Prof. Dr. Marcel Henrique Marcondes Sari
Dr. Raul Edison Luna Lazo
Guest Editors

Dr. Luana Mota Ferreira
Guest Editor Assistant

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Keywords

  • skin disorders
  • biotechnological formulations
  • nanocarriers
  • probiotic-based formulations
  • natural products
  • polysaccharides
  • skin delivery systems
  • bioactive compounds
  • antioxidant and anti-inflammatory effects
  • wound healing
  • safety and efficacy in skin therapies

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Published Papers (1 paper)

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Review

39 pages, 2250 KiB  
Review
Next-Generation Wound Care: A Scoping Review on Probiotic, Prebiotic, Synbiotic, and Postbiotic Cutaneous Formulations
by Patrícia Machado, Felipe Neme Ribeiro, Fernanda Cristina Wroblevski Giublin, Naomi Gerzvolf Mieres, Fernanda Stumpf Tonin, Roberto Pontarolo, Marcel Henrique Marcondes Sari, Raul Edison Luna Lazo and Luana Mota Ferreira
Pharmaceuticals 2025, 18(5), 704; https://doi.org/10.3390/ph18050704 - 9 May 2025
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Abstract
Background/Objectives: Chronic wounds represent a significant socioeconomic burden, affecting 1–2% of the global population. Wound healing is a complex process involving inflammation, cell proliferation, and tissue remodeling, but factors such as infections, diabetes, aging, and poor nutrition can impair recovery, leading to chronic [...] Read more.
Background/Objectives: Chronic wounds represent a significant socioeconomic burden, affecting 1–2% of the global population. Wound healing is a complex process involving inflammation, cell proliferation, and tissue remodeling, but factors such as infections, diabetes, aging, and poor nutrition can impair recovery, leading to chronic wounds. Given these challenges, researchers have explored topical probiotics, synbiotics, and postbiotics as alternatives strategies. Strains like Lactobacillus and Bifidobacterium contribute to skin restoration by producing antimicrobial, anti-inflammatory, and immunomodulatory compounds, offering a novel approach to cutaneous restoration. Our study aims to address the potential effects of topical probiotic, synbiotic, and postbiotic formulations for wound healing applications by means of a broad scoping review and evidence-gap mapping. Methods: A systematic literature search of preclinical studies (in vitro and in vivo) was performed in PubMed, Scopus, and Web of Science (January 2025), yielding 3052 articles after duplicates removal, of which 44 met the inclusion criteria. Results: These studies were published between 1986 and 2024, mostly by China (27.3%) and Iran (25.0%). Probiotics were frequently evaluated among the studies included (47.7%) (with Lactobacillus plantarum being the most assessed strain), followed by postbiotics (36.4%) (with predominant use of cell-free supernatants) and synbiotics (15.9%) (especially fructooligosaccharides). Dosage forms included gels (44.4%), films (15.6%), and ointments (13.3%). Conclusions: Most studies indicate that probiotics, synbiotics, and postbiotics have antimicrobial and anti-inflammatory properties, while promoting angiogenesis, tissue regeneration, and skin barrier restoration. The use of different delivery systems may additionally enhance therapeutic outcomes by accelerating wound closure, reducing bacterial load, and modulating immune response. However, methodological limitations in animal studies highlight the need for greater experimental rigor. Further robust clinical trials are essential to confirm efficacy and safety before clinical application of these formulations. Full article
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