Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 607

Special Issue Editors


E-Mail Website
Guest Editor
Faculty of Health Sciences (FCS), Post-Graduate Program in Health Sciences, Universidade Federal da Grande Dourados (UFGD), Dourados, MS, Brazil
Interests: ethnobotany; ethnopharmacology; anticancer; organoid models; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Universidade Federal da Grande Dourados (UFGD), Dourados, MS, Brazil
Interests: antioxidants; cytotoxicity; antitumor action; cancer; the prospection of bioactive molecules of natural and synthetic origin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains the second leading cause of mortality globally. It is estimated that by 2030, cancer will lead to almost 13 million deaths worldwide. Moreover, cancer therapies are constrained by the emergence of drug resistance and other associated challenges. Undoubtedly, there is a need for new drugs that are combined with natural compounds for better outcomes. Since oxidation has been implicated in the progression and development of cancer, antioxidants have been suggested as one of the viable solutions in its treatment. This is because antioxidants play significant roles in the preservation of cellular integrity and, therefore, in sustaining the homeostasis of the host immune system.

In this Special Issue, we welcome submissions of well-designed studies, relying on scientific methods and statistical analysis, that explore natural products—be it from plants, fungus, animals or other sources—which exhibit anticancer and antioxidant properties. 

Dr. Sikiru Olaitan Balogun
Dr. Edson Lucas Dos Santos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • anticancer
  • neoplasms
  • natural products
  • cytotoxicity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 8662 KB  
Article
Dihydroartemisinin Promotes N1 Polarization of Tumor-Associated Neutrophils and Enhances Their Anti-Tumor Activity via Hub Gene Modulation
by Wenjia Guo, Yu’e Liu, Wencong Ma, Jinghan Wang, Bingdi Chen and Lieying Fan
Pharmaceuticals 2026, 19(1), 88; https://doi.org/10.3390/ph19010088 (registering DOI) - 1 Jan 2026
Abstract
Background: Tumor-associated neutrophils (TANs) exhibit remarkable functional plasticity within tumor microenvironment (TME), with N1-like subtypes promoting anti-tumor immunity and N2-like subtypes facilitating tumor progression. Despite their critical role in cancer immunology, strategies to selectively modulate TAN polarization remain limited. Methods: We [...] Read more.
Background: Tumor-associated neutrophils (TANs) exhibit remarkable functional plasticity within tumor microenvironment (TME), with N1-like subtypes promoting anti-tumor immunity and N2-like subtypes facilitating tumor progression. Despite their critical role in cancer immunology, strategies to selectively modulate TAN polarization remain limited. Methods: We integrated transcriptomic analyses of TAN subtypes to identify potential hub molecules. Molecular docking and experimental assays were used to evaluate DHA’s effect on neutrophil-like cell polarization. Results: Hub genes (TNF, IL1B, PTGS2, BCL2A1, MSR1, ACOD1, CXCL16, CLEC10A, and SOCS3) were identified, with TNF serving as a potential core regulator. Molecular docking indicated that DHA forms stable interactions hub proteins. Experimentally, DHA treatment of neutrophil-like dNB4 cells promoted N1 polarization, evidenced by upregulation of TNF, IL1B, PTGS2, BCL2A1, MSR1, ACOD1, CXCL16, and N1 markers PD-L1 and NOX2, and downregulation of N2 marker CEACAM8 and hub genes CLEC10A and SOCS3. Functional assays demonstrated that DHA-treated cells exhibited increased secretion of TNF, IL1β, ROS, and PD-L1, accompanied by enhanced cytotoxic activity against hepatocellular carcinoma cells in a co-culture system. Conclusions: These findings reveal the molecular mechanisms underlying TAN polarization, and establish DHA as a potent immunomodulatory agent capable of reshaping TANs toward an anti-tumor phenotype. Full article
Show Figures

Graphical abstract

21 pages, 2930 KB  
Article
Antioxidant and Anticancer Activities of Water Extracts from Flowers, Leaves and Stems of In Vitro Cultivated and Wild-Growing Marrubium vulgare Plants
by Krasimira Tasheva, Ani Georgieva, Inna Sulikovska, Maria Petrova, Margarita Dimitrova, Lyudmila Dimitrova, Elena Georgieva, Petko Denev, Maria Lazarova and Polina Petkova-Kirova
Pharmaceuticals 2025, 18(12), 1806; https://doi.org/10.3390/ph18121806 - 26 Nov 2025
Viewed by 347
Abstract
Background/Objectives: Marrubium vulgare L. is a medicinal plant with diverse pharmacological properties, yet its in vitro cultivation and the biological potential of aqueous extracts of the plant remain poorly studied. The present research aimed to establish an efficient in vitro propagation protocol [...] Read more.
Background/Objectives: Marrubium vulgare L. is a medicinal plant with diverse pharmacological properties, yet its in vitro cultivation and the biological potential of aqueous extracts of the plant remain poorly studied. The present research aimed to establish an efficient in vitro propagation protocol and to compare the antioxidant and anticancer activities of freeze-dried water extracts from different parts (leaves, flowers, and stems) of in vitro cultivated and wild-growing M. vulgare plants. Methods: A micropropagation system was developed using Murashige and Skoog medium supplemented with kinetin and indole-3-acetic acid. Extracts from leaves, flowers, and stems were evaluated for the total polyphenol and flavonoid content, antioxidant capacity (ORAC, HORAC), and antiproliferative effects against HeLa, HT-29, and MCF-7 cancer cell lines. The mechanism of cytotoxicity was examined through apoptosis and cell cycle analysis. Results: The established protocol achieved high propagation efficiency (90% shoot formation). Cultivated leaves showed the highest polyphenol and flavonoid content and the strongest antioxidant activity. Aqueous extracts, particularly from leaves and flowers, displayed selective antiproliferative effects with HeLa cells being the most sensitive. The extracts induced apoptosis and cell cycle arrest –mainly at the G1 phase for cultivated plants and at both G1 and G2/M phases for wild plants. Conclusions: An efficient micropropagation protocol was successfully developed, providing a sustainable source of biologically active plant material. The study provides the first comprehensive comparison of M. vulgare water extracts from in vitro cultivated and wild-growing plants, linking phytochemical content with antioxidant and anticancer properties and highlighting both wild and in vitro cultivated plants, though wild plants in certain cases are generally more efficient, as promising candidates in natural anticancer therapeutics. The elevated flavonoid levels in in vitro cultivated plants, together with enhanced antioxidant capacity, indicate the strong potential of in vitro cultivated plants in antioxidant and cytoprotective formulations for cardiovascular, neurodegenerative, and metabolic diseases. Full article
Show Figures

Graphical abstract

Back to TopTop