Advances in and Perspectives on Oral Drug Delivery
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: 25 April 2026 | Viewed by 124
Special Issue Editors
Interests: enhanced drug delivery; oral route; low aqueous solubility and low permeability; enhanced oral bioavailability; transporter targeting; emerging materials and excipients in oral delivery; dosage form transition of already marketed drugs; examining herbal or traditional drugs oral delivery; sustained release; nanotechnology; application of cellular components such as exosomes or vesicles for oral delivery; nanocarriers; lipid-based formulations; self-emulsifying drug delivery systems (SEDDS); solid dispersions; mucoadhesive systems
Interests: bioavailability enhancement; biopharmaceutics; cancer nanotechnology; enzyme inhibitors; absorption enhancers; targeted drug delivery; controlled release; smart drug delivery systems; nanomedicine; translational pharmaceutics; physiologically based pharmacokinetic modeling (PBPK); patient-centric formulations
Special Issue Information
Dear Colleagues,
Oral drug delivery remains the most convenient and patient-preferred route of administration. However, significant challenges limit its effectiveness, including poor solubility and permeability, instability in the gastrointestinal tract, enzymatic degradation, and barriers to delivering complex therapeutics such as peptides and biologics. This Special Issue, guest-edited by experts in formulation technology and biopharmaceutics, aims to showcase cutting-edge research and critical reviews that advance the science and practice of oral delivery.
We welcome contributions focusing on innovative formulation strategies (e.g., lipid-based systems, nanocarriers, and solid dispersions), mechanistic studies on absorption and transporter targeting, and studies presenting novel approaches for oral peptides and biologics, advanced tools such as PBPK modeling, and translational or regulatory perspectives. Emphasis will be placed on advances that improve bioavailability, stability, targeted release, disease-specific dosing strategies, long-term plasma retention, and patient compliance.
The objectives of this Special Issue are as follows:
- To highlight innovative formulation strategies that overcome the challenges of solubility, permeability, stability, and patient compliance in oral drug delivery;
- To present mechanistic insights into drug absorption, transporter interactions, and enzymatic degradation in the gastrointestinal tract;
- To explore novel approaches for the oral delivery of challenging molecules, including peptides, proteins, nucleic acids, and natural products;
- To encourage research on transitioning established injectable drugs into patient-centric oral dosage forms;
- To provide perspectives on translational and regulatory pathways that can accelerate clinical adoption of advanced oral delivery technologies.
Dr. Laxman Subedi
Dr. Mohammad Imran
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- enhanced drug delivery
- oral route
- oral peptide delivery
- 3D printing
- continuous manufacturing
- PBPK modeling
- nanocarriers
- translational pharmaceutics
- low aqueous solubility and low permeability
- enhanced oral bioavailability
- transporter targeting
- emerging materials and excipients in oral delivery
- dosage form transition of already marketed drugs
- examining herbal or traditional drugs oral delivery
- sustained release
- nanotechnology
- application of cellular components such as exosomes or vesicles for oral delivery
- in silico docking for PBPK
- nanocarriers
- lipid-based formulations
- self-emulsifying drug delivery systems (SEDDS)
- solid dispersions
- mucoadhesive systems
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