Molecular Insights and Clinical Implications in Geriatric Medicine and Drug Development

Dear Colleagues,

The aging of the human body is a universal and irreversible process that, despite being often euphemized in everyday language, has profound implications for healthcare systems worldwide. As life expectancy and the proportion of older adults continue to rise in developed nations, addressing the complex clinical needs of this demographic has become a priority in modern medicine and pharmaceutical sciences.

Aging is closely associated with the emergence of Geriatric Giants—multifactorial conditions such as malnutrition, falls, cognitive decline, and incontinence, all of which significantly diminish functional independence. Additionally, geriatric patients are commonly affected by multimorbidity and require multiple medications, which heightens the risk of adverse drug–drug and drug–nutrient interactions.

In such contexts, timely and precise diagnostics are critical. Laboratory medicine and biomarker measurement are gaining recognition as essential tools in assessing clinical status, enabling earlier intervention, optimizing therapeutic strategies, and ultimately improving outcomes. An assessment of the relationship between the patient's condition and changes in laboratory parameters is crucial for proper management and a personalized approach to the patient. At the same time, there is an urgent need for innovative, personalized pharmacological approaches adapted to older individuals' unique physiological and clinical profiles.

This Special Issue invites high-quality original research and comprehensive reviews that address the medical and pharmacological complexities of aging. We particularly welcome submissions that explore the clinical application of biomarkers in geriatric diagnostics and studies on the discovery and development of novel therapeutics, spanning from computational modeling and laboratory research to clinical trials and regulatory approval.

Join us in advancing the geriatric medicine and pharmacy field by contributing to this timely and impactful collection.

Dr. Katarzyna Mądra-Gackowska
Dr. Marcin Gackowski
Prof. Dr. Kornelia Kędziora-Kornatowska
Dr. Iga Hołyńska-Iwan
Guest Editors

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